Citric acid crosslinked carboxymethylcellulose-poly(ethylene glycol) hydrogel films for delivery of poorly soluble drugs

Ghorpade, Vishwajeet Sampatrao; Yadav, Adhikrao Vyankatrao; Dias, Remeth J.; Mali, Kailas K.; Pargaonkar, Sandhya Shamrao; Shinde, Pooja Vikram; Dhane, Nikhil Sampat

doi:10.1016/j.ijbiomac.2018.06.142

Cited by 97 publications

(44 citation statements)

References 34 publications

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“…Interestingly, the release rate of ketoconazole increased due to the increase in drug loading and reduction in crosslinking. Overall, such a type of combination can be used for extended-release of active up to 12 h [17]. In 2020, Hussain and co-author developed the cross-linking of a glucuronoxylan obtained from Mimosa pudica (MP) seed.…”

Section: Ca As a Green Crosslinkermentioning

confidence: 99%

Pharmaceutical applications of citric acid

et al. 2021

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Background Citric acid (CA) is a universal plant and animal-metabolism intermediate. It is a commodity chemical processed and widely used around the world as an excellent pharmaceutical excipient. Notably, CA is offering assorted significant properties viz. biodegradability, biocompatibility, hydrophilicity, safety, etc. Therefore, CA is broadly employed in many sectors including foodstuffs, beverages, pharmaceuticals, nutraceuticals, and cosmetics as a flavoring agent, sequestering agent, buffering agent, etc. From the beginning, CA is a regular ingredient for cosmetic pH-adjustment and as a metallic ion chelator in antioxidant systems. In addition, it is used to improve the taste of pharmaceuticals such as syrups, solutions, elixirs, etc. Furthermore, free CA is also employed as an acidulant in mild astringent preparations. Main text In essence, it is estimated that the functionality present in CA provides excellent assets in pharmaceutical applications such as cross-linking, release-modifying capacity, interaction with molecules, capping and coating agent, branched polymer nanoconjugates, gas generating agent, etc. Mainly, the center of attention of the review is to deliver an impression of the CA-based pharmaceutical applications. Conclusion In conclusion, CA is reconnoitered for multiple novels pharmaceutical and biomedical/applications including as a green crosslinker, release modifier, monomer/branched polymer, capping and coating agent, novel disintegrant, absorption enhancer, etc. In the future, CA can be utilized as an excellent substitute for pharmaceutical and biomedical applications. Graphical abstract

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Section: Ca As a Green Crosslinkermentioning

confidence: 99%

Pharmaceutical applications of citric acid

et al. 2021

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“…Tricarboxylic acid (citric acid, CA) was used as an esterification agent, which, according to literature [30,31], can support CMC coupling to CNF via available hydroxyl groups, as shown in simplified Scheme 1a. The CA may react with each of the three hydroxyl groups in the anhydroglucose monomers, preferably with those at the C-6 position [32], as well as with the reducing ends of the carbohydrates, resulting in mono-, di-, and tri-esters [33]. The ATR-FTIR data of components used in CNF/CMC membranes casting (Figure 2a) revealed typical bands related to their components.…”

Section: Esterification and Oxidation Within Cellulose-based Membranesmentioning

confidence: 99%

Efficiency of Differently Processed Membranes Based on Cellulose as Cationic Dye Adsorbents

et al. 2020

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In order to minimize the pollution caused by the reuse of textile dyes, technologies and materials have been developed that purify waste water in an efficient and cost-effective manner before it is discharged into a water body. In this context, the presented research investigates the potential of two types of fully cellulose-based membranes as adsorbents for cationic dyes used in the textile industry. The first type combines cellulose nanofibrils (CNFs) and carboxymethylated cellulose (CMC) using the solvent casting process and an esterification coupling reaction, while the second type uses commercial bacterial cellulose (BC) in a native and sodium periodate-treated form (BCox). The corresponding membranes were comprehensively evaluated by means of Fourier Transform Infrared (FTIR) Spectroscopy. Results confirm the esterification process within the CNF/CMC membranes, as well as BC oxidation after periodate treatment, as shown by bands at 1726.2 cm−1 and 895 cm−1, respectively. The Potentiometric Titration shows the highest total negative charge of 1.07 mmol/g for 4CNF/4CMC, which is assigned to the presence of COO− within CMC polymers, and lowest (0.21 mmol/g) for BCox. The Contact Angle Goniometry data confirm the hydrophilicity of all membranes, and the angle increased from 0 ° (in pure BC) to 34.5 ° in CMC-rich and to 31.4 ° in BCox membranes due to the presence of CH2COO− and CHO groups, respectively. Confocal Fluorescent Microscopy (CFM) demonstrated the highest µ-roughness in 4CNF/4CMC, while Scanning Electron Microscopy (SEM) depicted diverse morphological features between the membranes, from ultrafine nanofiber networks (in BC and BCox) to larger fiber bundles connected within the polymer phase in CNF/CMC membranes. The adsorption experiment followed by UV–VIS spectroscopy, showed ~100% dye removal efficiency in both CNF/CMC-based membranes, while BC and BCox adsorbed only 24.3% and 23.6%, respectively, when anthraquinone dye was used. Azo dye was only adsorbed with an efficiency of 7–9% on CMC/CNF-based membranes, compared with 5.57% on BC and 7.33% on BCox membranes. The adsorption efficiency at equilibrium was highest for BC (1228 mg/g) and lowest for 7CNF/1CMC (419.24 mg/g) during anthraquinone dye adsorption. In the case of azo dye, the BCox was most effective, with 445.7 mg/g. Applicability of a pseudo second-order model was confirmed for both dyes and all membranes, except for BCox in combination with azo dye, showing the fastest adsorption rate in the case of the 7CNF/1CMC membrane.

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“…Citric acid is an ingredients in the NCH injection formulation [29] and a crosslinker of CMC. [30,31] To dissolve NCH in the acidic solution, solid NCH was first dissolved in citric acid in a separate solution, and then, the NCH solution was combined with the CMC solution to obtain citric acid-crosslinked CMC nanogel particles. Conversely, the NCH and CMC solution were insoluble in each other.…”

Section: Nch-cmc/plga Nanocarrier Synthesismentioning

confidence: 99%

Kinetics of Drug Release via Nicardipine Hydrochloride‐loaded Carboxymethyl Cellulose/Poly(D,L‐lactic‐co‐glycolic acid) Nanocarriers Using a Contemporary Emulsion Process

et al. 2020

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A contemporary synthesis of polymeric nanocarriers based on drug delivery systems was employed using a water in oil in water (W 1 /O/W 2) double emulsion process to develop nicardipine hydrochloride-loaded carboxymethyl cellulose/ poly(D,L-lactic-co-glycolic acid) (NCH-CMC/PLGA) nanocarriers. The optimal synthesis of the nanocarriers was studied, including polymer amount, cross-linker concentration, and emulsifier concentration. The synthesized nanocarriers were smaller than~169 nm and showed a drug encapsulation of more than 80% and a yield of 51% to 73%. The NCH-CMC/ PLGA nanocarriers presented good stability in aqueous dispersion for 10 days. Controlled drug release from the nanocarriers was slow and continuous for up to 16 days. The nanocarriers protected the drug against degradation and maintained therapeutic drug concentrations. In addition, the transport of drug release was studied via five conventional mathematical modelings such as Zero-order model, Firstorder model, Hixson-Crowell model, Higuchi model, and Korsmeyer-Peppas model. The Korsmeyer-Peppas model was fitted to achieve mathematical modeling for the optimized formulation of nanocarriers. Moreover, significant cytocompatibility was observed at all tested doses of NCH-CMC/PLGA nanocarriers. The NCH-CMC/PLGA nanocarriers could be an effective drug delivery agent for calcium channel blockers.

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Citric acid crosslinked carboxymethylcellulose-poly(ethylene glycol) hydrogel films for delivery of poorly soluble drugs

Cited by 97 publications

References 34 publications

Pharmaceutical applications of citric acid

Pharmaceutical applications of citric acid

Efficiency of Differently Processed Membranes Based on Cellulose as Cationic Dye Adsorbents

Kinetics of Drug Release via Nicardipine Hydrochloride‐loaded Carboxymethyl Cellulose/Poly(D,L‐lactic‐co‐glycolic acid) Nanocarriers Using a Contemporary Emulsion Process

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