CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein

Wang, Jing; Zheng, Li; Hu, Chundong; Kong, Demiao; Zhou, Zhongli; Wu, Bin; Wu, Shaohan; Fei, Famin; Shen, Yiyu

doi:10.1016/j.cellsig.2023.110661

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…CircRNAs also regulate EMT in cancer cells. Wang et al ( 92 ) demonstrated that circZFR sponges miR-375 to enhance the expression of gremlin 2 (GREM2), which is a target gene of miR-375. By increasing GREM2 expression, circZFR enhances the activation of the JNK pathway to promote EMT in pancreatic cancer cells, facilitating metastasis in pancreatic cancer ( 92 ).…”

Section: Role Of Ncrnas In Cancer Plasticitymentioning

confidence: 99%

“…Wang et al ( 92 ) demonstrated that circZFR sponges miR-375 to enhance the expression of gremlin 2 (GREM2), which is a target gene of miR-375. By increasing GREM2 expression, circZFR enhances the activation of the JNK pathway to promote EMT in pancreatic cancer cells, facilitating metastasis in pancreatic cancer ( 92 ). Various excellent reviews have specifically discussed the mechanisms by which ncRNAs regulate CSCs and EMT in cancer ( 93 – 96 ).…”

Section: Role Of Ncrnas In Cancer Plasticitymentioning

confidence: 99%

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Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)

Zhang,

Liang,

Zhang

et al. 2023

Oncol Rep

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Plasticity, the ability of cancer cells to transition between differentiation states without genomic alterations, has been recognized as a major source of intratumoral heterogeneity. It has a crucial role in cancer metastasis and treatment resistance. Thus, targeting plasticity holds tremendous promise. However, the molecular mechanisms of plasticity in cancer cells remain poorly understood. Several studies found that mRNA, which acts as a bridge linking the genetic information of DNA and protein, has an important role in translating genotypes into phenotypes. The present review provided an overview of the regulation of cancer cell plasticity occurring via changes in the transcription and editing of mRNAs. The role of the transcriptional regulation of mRNA in cancer cell plasticity was discussed, including DNA-binding transcriptional factors, DNA methylation, histone modifications and enhancers. Furthermore, the role of mRNA editing in cancer cell plasticity was debated, including mRNA splicing and mRNA modification. In addition, the role of non-coding (nc)RNAs in cancer plasticity was expounded, including microRNAs, long intergenic ncRNAs and circular RNAs. Finally, different strategies for targeting cancer cell plasticity to overcome metastasis and therapeutic resistance in cancer were discussed.

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Section: Role Of Ncrnas In Cancer Plasticitymentioning

confidence: 99%

Section: Role Of Ncrnas In Cancer Plasticitymentioning

confidence: 99%

Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)

Zhang,

Liang,

Zhang

et al. 2023

Oncol Rep

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show abstract

“…A recent study showed that pancreatic cancer tissues consist of upregulated circZFR, causing increased 2 of 28 tumorigenicity and promoting cell proliferation. A study showed that circZFR sponging miR-375 caused the JNK signaling pathway to initiate GREM2 upregulation in cells found in the pancreatic cancer [9]. Studies have found that small nucleolar RNA host gene 1 (SNHG1) is a lncRNA that is regulated in the development of bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Functions of Circular RNA in Human Diseases and Illnesses

Jaijyan

Yang

et al. 2023

ncRNA

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Circular RNAs (circRNAs) represent single-stranded RNA species that contain covalently closed 3′ and 5′ ends that provide them more stability than linear RNA, which has free ends. Emerging evidence indicates that circRNAs perform essential functions in many DNA viruses, including coronaviruses, Epstein–Barr viruses, cytomegalovirus, and Kaposi sarcoma viruses. Recent studies have confirmed that circRNAs are present in viruses, including DNA and RNA viruses, and play various important functions such as evading host immune response, disease pathogenesis, protein translation, miRNA sponges, regulating cell proliferation, and virus replication. Studies have confirmed that circRNAs can be biological signatures or pathological markers for autoimmune diseases, neurological diseases, and cancers. However, our understanding of circRNAs in DNA and RNA viruses is still limited, and functional evaluation of viral and host circRNAs is essential to completely understand their biological functions. In the present review, we describe the metabolism and cellular roles of circRNA, including its roles in various diseases and viral and cellular circRNA functions. Circular RNAs are found to interact with RNA, proteins, and DNA, and thus can modulate cellular processes, including translation, transcription, splicing, and other functions. Circular RNAs interfere with various signaling pathways and take part in vital functions in various biological, physiological, cellular, and pathophysiological processes. We also summarize recent evidence demonstrating cellular and viral circRNA’s roles in DNA and RNA viruses in this growing field of research.

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(+)‐Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways

Ni,

Zhu,

Chen

et al. 2024

Molecular Nutrition Food Res

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ScopeDiabetic nephropathy (DN), a complication of diabetes mellitus, is becoming a significant global health concern, with no complete cure currently available. Tea is regarded as an essential component of a balanced diet and contains (+)‐Catechin (CE), which exert a range of pharmacological effects. Consequently, CE may be a potential treatment for DN. The objective of this study is to examine the protective effects and underlying mechanisms of CE on DN, with a particular focus on the epithelial‐mesenchymal transition (EMT) process, which plays a pivotal role in regulating DN.Methods and resultsIn this study db/db mice are treated with catechins. The results demonstrate that CE reduces obesity and hyperglycemia, improves renal dysfunction and morphological changes in diabetic mice, and inhibits the development of DN through the RAGE/NF‐κB signaling pathway. Among them differentially expressed messenger RNA (mRNA) results, those related to EMT, including Cav1, grem2, macrod2, and kap, are identified. To further validate the results, the same experiments are performed on HK‐2 cells.ConclusionsThe research results offer novel perspectives by emphasizing the anti‐inflammatory properties of CE and their potential role in mitigating DN through the regulation of EMT‐related genes such as RAGE, Cav1, grem2, macrod2, and kap.

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CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein

Cited by 5 publications

References 35 publications

Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)

Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)

Functions of Circular RNA in Human Diseases and Illnesses

(+)‐Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways

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