Circulation in the Fundus of the Rabbit Eye*

Fluorescence Cineangiographic and Histological Studies on the Rabbit Eye During Experimental Hypercholesteremia

“…The capillary circulation did not exhibit any variation from the normal described earlier (Hyvarinen 1967 b), and the capillary flow velocity measured in 19 films from different phases of the experimental series did not differ from the normal velocity.…”

“…When this finding was checked two days later, the flow pattern was again completely normal. This finding was interpreted as a transient spasm of the artery; it was the only time that a spasm in the retinal vessels of unanaesthetized rabbit was recorded in the total material of more than 400 experiments made in this and the previous work (Hyvarinen 1967 b).…”

“…Chirnges zn the circulation of the fundus: The fluorescence cineangiograms exhibited general features whicb resembled the cineangiograms of normal animals (Hyvarinen 1967 b) in alf the experiments during the six months of hypercholesteremia. The dye did not penetrate outside the retinal vessels, whereas a marked increase in the diffusion into the anterior chamber was apparent in several eyes during the fifth and sixth months; the fluorescein also entered the anterior chamber of the other eye, of which the pupil was not enlarged, and remained in the anterior chambers for a number of hours.…”

“…The retinal circulation time could be measured in the same way as with normal animals, to an accuracy of 5/24 sec. for the endpoint of venous filling (Hyvarinen 1967 b) in 180 films of the present film material. Of these, 45 were discarded from the analysis of variation in the retinal circulation times, as they did not form a part of any complete series of measurements in successive months of hypercholesteremia.…”

“…The average dispersion of all the circulation times during hypercholesteremia was found to be greater than the average dispersion of circulation times 61 in normal Lnimais during the earlier study. A special application of one-way analysis of variance was designed to test whether the variation of circulation times of hypercholestereinic rabbits was significantly larger than that of normal animals (Hyvarinen 1967 b). The variation of circulation times of hypercholesteremic rabbits proved to be significantly larger at the 0.1 O/O level.…”