Circulating visfatin level is correlated with inflammation, but not with insulin resistance

Oki, Kenji; Yamane, Kiminori; Kamei, Nozomu; Nojima, Hideki; Kohno, Nobuoki

doi:10.1111/j.1365-2265.2007.02966.x

Cited by 121 publications

(95 citation statements)

References 25 publications

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“…However, more recent in vivo and in vitro studies have suggested that visfatin may be related to insulin-resistance, endothelial dysfunction, and increased inflammation. [3][4][5][6] Despite these findings, it should be noted that comprehensive results do not yet exist about the pathophysiological role of visfatin. [4] Dialysis patients are suggested to have increased several adipocytokines (adiponectin, leptin, interleukin 6 [IL-6], tumor necrosis factor-α [TNF-α]), particularly due to low renal clearance.…”

Section: Introductionmentioning

confidence: 83%

“…[1,4,5] Additionally, a few studies have suggested that visfatin may have proinflammatory characteristics. [3,4,6] There are two studies in the literature demonstrating a positive relationship between serum level of IL-6 and visfatin. [3,6] Likewise, our study has also found an independent and significant positive relationship between visfatin and two of the important inflammatory cytokines, TNF-α and IL-6.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4,6] There are two studies in the literature demonstrating a positive relationship between serum level of IL-6 and visfatin. [3,6] Likewise, our study has also found an independent and significant positive relationship between visfatin and two of the important inflammatory cytokines, TNF-α and IL-6. These results might confirm that visfatin might be a proinflammatory adipocytokine.…”

Section: Discussionmentioning

confidence: 99%

“…[8] Recently, a relationship between visfatin and these adipocytokines have been suggested in healthy subjects. [3,6] Increased levels of IL-6 and TNF-α have been demonstrated to be related with left ventricular hypertrophy (LVH) in dialysis patients. [8][9][10] This suggests a relationship between visfatin, which is thought to be a proinflammatory cytokine, and LVH, though such a relationship has not yet been explored in the literature.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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Visfatin was recently defined as an adipocytokine; however, the pathophysiological role of visfatin is not completely understood. A few studies suggest that visfatin may be a new proinflammatory adipocytokine. The aim of the present study was to compare serum visfatin levels between hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients and evaluate the relationship between visfatin levels to IL-6, TNF-α, and left ventricular hypertrophy. Serum visfatin, IL-6, and TNF-α levels were measured by using the ELISA method, and echocardiographic evaluations were performed in 31 hemodialysis patients, 30 CAPD patients, and 21 healthy volunteers. Serum visfatin levels were higher in the CAPD group (265.27 ± 387.86 ng/mL) than hemodialysis (97.68 ± 244.96 ng/mL,) and control (41.33 ± 48.87 ng/mL) groups (p = 0.04, p = 0.01, respectively). No significant difference was observed between the hemodialysis and control groups. In univariate analysis, visfatin levels were positively correlated with IL-6 (r = 0.24, p = 0.03), TNF-α (r = 0.34, p = 0.002), and BMI (r = 0.26, p = 0.03) and negatively correlated with some left ventricular diastolic parameters [Em and Em/Am (r = −0.305, p = 0.01), (r = −0.251, p = 0.03), respectively]. No relationship was found between visfatin and left ventricular mass index. In the linear regression analysis, visfatin levels independently related with TNF-( (β = 0.369, p = 0.001) and p = 0.015). This study has found significantly higher levels of serum visfatin in CAPD patients when compared to healthy individuals. Increased visfatin levels seem to associate with proinflammatory cytokines such as IL-6 or TNF-α. As for the effects of on left ventricular structure and functions, visfatin might have negative effects on left ventricular diastolic function parameters but have no effects on left ventricular mass index.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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“…In this Japanese American population-based study, the subjects have been reported to develop dyslipidaemia and obesity more rapidly than Japanese living in Japan because of a Westernised food habit in which Japanese Americans ingested more fat of animal origin and of a lower PUFA:SFA ratio than native Japanese (7,8) . Therefore, we considered that these populations * Corresponding author: Dr Kiminori Yamane, fax þ81 82 255 7360, email yamanek@hiroshima-u.ac.jp Abbreviations: %fat, percentage body fat; HMG, 3-hydroxy-3-methylglutaryl; HOMA-IR, homeostasis model assessment for insulin resistance; SNP, single nucleotide polymorphism.…”

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The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women

et al. 2008

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Insulin-induced gene 2 (insig-2) protein is known to play important roles in cholesterol and TAG metabolism both in vivo and in vitro. One particularly interesting single nucleotide polymorphism (SNP), rs7566605, located 10 kb upstream of INSIG2 was reported to have the strongest association with obesity among 86 604 SNP, while the relationship with dyslipidaemia is uncertain. Eight hundred and eighty-five Japanese Americans (347 men and 538 women) and 378 Japanese (182 men and 196 women) were enrolled, and the rs7566605 SNP, which is consistent with either G or C, was determined. We investigated the association between the rs7566605 SNP and the prevalence of hypercholesterolaemia or hypertriacylglycerolaemia, or obesity parameters, as assessed by BMI, waist girth and percentage body fat. There were no significant differences in BMI, waist girth and percentage body fat according to the genotype in each of the four groups, which was divided by population and sex. The prevalence of hypercholesterolaemia was significantly different between the genotypes in Japanese American female subjects (GG, 62·2 %; GC, 57·1 %; CC, 42·1 %; P¼ 0·021), but not in the other subjects. In Japanese American women, the subjects with the CC genotype had a 0·43-fold decreased risk (95 % CI 0·24, 0·80) for hypercholesterolaemia compared with the GG genotype after adjustment for age, percentage body fat, smoking status and hormone replacement therapy. The CC genotype of the rs7566605 SNP is suggested to be a protective genetic factor against the progression of hypercholesterolaemia on a high-fat diet, especially in Japanese female subjects.INSIG2: Polymorphisms: Dyslipidaemia: Obesity: High-fat diet Insulin-induced gene insig proteins, including insig-1 and insig-2, play many important roles in regulating cholesterol or TAG synthesis, mainly in the liver. 3-Hydroxy-3-methylglutaryl (HMG)-CoA reductase, a rate-limiting enzyme in cholesterol synthesis, catalyses the reduction of HMG-CoA to mevalonate (1) . Overexpression of insig proteins can activate the degradation of HMG-CoA reductase in Chinese hamster ovary cells in vitro (2) . The knockdown of insig-2 by RNA interference suppresses the degradation of HMG-CoA reductase in SV-589 cells (3) . In addition, insig-2-overexpressing mice exhibit lower plasma TAG levels compared with wild-type mice, independent of food intake, body weight and fat weight (4) , which suggests the association between insig-2 and TAG metabolism. Taken together, it is suggested that insig-2 is strongly related to cholesterol and TAG metabolism through the level of insig-2 expression.Recently, an interesting single nucleotide polymorphism (SNP), rs7566605, which is located 10 kb upstream of INSIG2, was found to be associated with obesity, as assessed by BMI (5) . This polymorphism was identified from a genomewide association scan of 86 604 SNP in the Framingham Heart Study offspring cohort. In the report, the relationship with obesity was confirmed in four out of five additional cohorts (5) . Moreover, Lyon et al. id...

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Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases

Dakroub

Nasser

Kobeissy

et al. 2021

Journal Cellular Physiology

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Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/ NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis, all of which pose increased risks of cardiovascular events. In this context, increased levels of visfatin have been correlated with several upregulated pro-inflammatory mediators, such as IL-1, IL-1Ra, IL-6, IL-8, and TNF-α. Furthermore, visfatin is associated with leukocyte recruitment by endothelial cells and the production of adhesion molecules such as vascular cell adhesion molecule 1, intercellular cell adhesion molecule 1, and E-selectin, which are well known to mediate the progression of atherosclerosis. Moreover, diverse angiogenic factors have been found to mediate visfatin-induced angiogenesis. These include matrix metalloproteinases, vascular endothelial growth factor, monocyte chemoattractant protein 1, and fibroblast growth factor 2. This review aims to provide aThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Circulating visfatin level is correlated with inflammation, but not with insulin resistance

Abstract: Serum visfatin levels were positively correlated with the serum levels of IL-6 and slightly related with serum levels of CRP, but not with HOMA-IR, in Japanese Americans. Our results indicate that circulating visfatin may reflect inflammation status.

Cited by 121 publications

References 25 publications

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women

Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases

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