Circulating testosterone and estradiol, autonomic balance and baroreflex sensitivity in middle-aged and elderly men with heart failure

Rydlewska, Agnieszka; Maj, Jolanta; Katkowski, Bartosz; Biel, Bartosz; Ponikowska, Beata; Banasiak, Waldemar; Ponikowski, Piotr; Jankowska, Ewa A.

doi:10.3109/13685538.2013.768979

Cited by 21 publications

(18 citation statements)

References 53 publications

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“…These animals also demonstrated greater increases in microvascularization, thus generating greater nutrition and oxygenation of the organ, maintaining a balance of myocardium components and minimizing the morphofunctional changes associated with aging. These results are in accordance with the results showed by Rydlewska et al [24] and Florvaag et al [25], both papers show beneficial effects of testosterone treatment in cases of heart problems.…”

Section: Discussionsupporting

confidence: 93%

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

et al. 2014

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Section: Discussionsupporting

confidence: 93%

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

et al. 2014

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“…Such studies have focused on men with known CVD. Rydlewska and colleagues noted that among men with mild systolic congestive heart failure, men with lower testosterone concentrations had decreases in parasympathetic tone as indicated by baroreflex sensitivity [29]. Similarly, Wranicz and colleagues noted than in 88 middle-aged men who had experienced a myocardial infarction, lower testosterone concentrations (<530 ng/dL) were associated with decreased (less favorable) heart rate variability [30].…”

Section: Discussionmentioning

confidence: 97%

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

Kim

Pop‐Busui

Braffett

et al. 2015

The Journal of Sexual Medicine

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Introduction Previous studies have reported that lower testosterone concentrations are associated with cardiovascular autonomic neuropathy (CAN), a risk factor for cardiovascular events. However, no studies have examined this relationship in men with type 1 diabetes, who are at high risk for CAN. Aim To examine the associations between testosterone concentrations and measures of CAN in a large, well-characterized cohort of men with type 1 diabetes. Methods We conducted an analysis of men in the Diabetes Control and Complications Trial (DCCT), a randomized trial of intensive glucose control, and its observational follow-up the Epidemiology of Diabetes Intervention and Complications (EDIC) Study. Testosterone was measured by liquid chromatography mass spectrometry in stored samples from EDIC follow-up years 10 and 17. Regression models were used to assess the cross-sectional relationships between testosterone and CAN measures. Main Outcome Measures The main CAN measure from EDIC follow-up year 17 was a standardized composite of R-R variation with paced breathing < 15, or R-R variation 15-20 combined with either a Valsalva ratio ≤ 1.5 or a decrease in diastolic blood pressure > 10 mm Hg upon standing. Continuous R-R variation and Valsalva ratio were secondary outcome measures. Results Lower total and bioavailable testosterone concentrations at follow-up years 10 and 17 were not associated with the presence of CAN at year 17. In analyses using Valsalva ratio as a continuous measure, higher total (p=0.01) and bioavailable testosterone concentrations (p=0.005) were associated with a higher (more favorable) Valsalva ratio after adjustment for covariates including age, body mass index, smoking status, hypertension, and glycemic control. Conclusions Testosterone levels are not associated with CAN among men with type 1 diabetes. Although testosterone is associated with a higher Valsalva ratio, a more favorable indicator, the clinical significance of this association is not known.

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“…This phenomenon seems to be more progressive in heart failure state leading inappropriate physical, cardiovascular, or psychological consequences. In a recent report, deficiencies in circulating testosterone were reported in 13% of heart failure patients that the reduced circulating testosterone was associated with lower heart rate variability and depleted baroreflex sensitivity [24]. In this line, it has been observed that low levels of growth hormone and testosterone have been associated with increased mortality and morbidity in patients with heart failure [25, 26].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

Mirdamadi

Garakyaraghi

Pourmoghaddas

et al. 2014

BioMed Research International

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Background. According to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone therapy improves clinical and cardiovascular conditions as well as quality of life status in patients with stable chronic heart failure. Methods. A total of 50 male patients who suffered from congestive heart failure were recruited in a double-blind, placebo-controlled trial and randomized to receive an intramuscular (gluteal) long-acting androgen injection (1 mL of testosterone enanthate 250 mg/mL) once every four weeks for 12 weeks or receive intramuscular injections of saline (1 mL of 0.9% wt/vol NaCl) with the same protocol. Results. The changes in body weight, hemodynamic parameters, and left ventricular dimensional echocardiographic indices were all comparable between the two groups. Regarding changes in diastolic functional state and using Tei index, this parameter was significantly improved. Unlike the group received placebo, those who received testosterone had a significant increasing trend in 6-walk mean distance (6MWD) parameter within the study period (P = 0.019). The discrepancy in the trends of changes in 6MWD between study groups remained significant after adjusting baseline variables (mean square = 243.262, F index = 4.402, and P = 0.045). Conclusion. Our study strengthens insights into the beneficial role of testosterone in improvement of functional capacity and quality of life in heart failure patients.

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Circulating testosterone and estradiol, autonomic balance and baroreflex sensitivity in middle-aged and elderly men with heart failure

Cited by 21 publications

References 53 publications

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

Resistance exercise and testosterone treatment alters the proportion of numerical density of capillaries of the left ventricle of aging Wistar rats

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

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