Circulating miRNA levels differ with respect to carotid plaque characteristics and symptom occurrence in patients with carotid artery stenosis and provide information on future cardiovascular events

Badacz, Rafał; Przewłocki, Tadeusz; Gacoń, Jacek; Stępień, Ewa; Enguita, Francisco J.; Karch, Izabela; Żmudka, Krzysztof; Kabłak‐Ziembicka, Anna

doi:10.5114/aic.2018.74358

Cited by 22 publications

(21 citation statements)

References 35 publications

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“…It was reported that a wide variety of pro‐inflammatory and anti‐inflammatory miRNAs could play distinct roles in the pathogenesis of IS in relevance to neuro‐inflammation (Gaudet, Fonken, Watkins, Nelson, & Popovich, ), as well as in the pathobiology of atherosclerosis (Feinberg & Moore, ; Laffont & Rayner, ). Consequently, similar to the conventional inflammatory biomarkers, miRNAs were also identified as potential diagnostic or prognostic targets for IS (Badacz et al, ; Gacon et al, ; Li, Efendizade, & Ding, ; Shekhar et al, ; Xu et al, ). A recent study further demonstrated that circulating miRNAs in human blood serum might be used to differentiate the IS etiological subtypes (Gui et al, ).…”

Section: Introductionmentioning

confidence: 99%

Inflammation‐regulatory microRNAs: Valuable targets for intracranial atherosclerosis

Chen

2019

J of Neuroscience Research

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Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and unstable inflammatory process within intracranial arteries. Then, as a topic of discussion, we mainly concentrate on the following crucial miRNAs (miR-155, miR-27a/b, miR-342-5p, miR-21, miR-124, and miR-223) by virtue of their multiple roles in regulating the progression of atherosclerosis involved with systemic and local inflammatory activities in cerebral arteries. Clinical perspectives of other miRNAs (miR-146a, miR-181b, miR-126, miR-143, and let-7b) in ICAS are also mentioned. In relevance to the inflammatory mechanisms of ICAS, the in-depth knowledge of miRNAs engaged in the progression of intracranial atherosclerotic plaques may provide an approach to a more precise exploration of diagnostic and therapeutic targets for ICAS.

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Section: Introductionmentioning

confidence: 99%

Inflammation‐regulatory microRNAs: Valuable targets for intracranial atherosclerosis

Chen

2019

J of Neuroscience Research

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“…Patients with symptoms from the carotid artery were characterized with lower expression of miR-1. This finding might be potentially attributed to the different mechanisms of coronary and carotid ischemia [22][23][24].…”

Section: Discussionmentioning

confidence: 96%

Expression of miR-1-3p, miR-16-5p and miR-122-5p as Possible Risk Factors of Secondary Cardiovascular Events

et al. 2021

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Ischemic event in one arterial territory increases the risk of a subsequent ischemic event. Circulating microRNAs (miRs) emerge as a potential clinical tool to assess risk of subsequent atherothrombotic events such as cardiovascular death (CVD), myocardial infarction (MI) and ischemic stroke (IS). In this prospective study, we searched for athero-specific miRs related to cardiovascular event risk in patients with symptomatic coronary, carotid lesion, or both territories involvements. The choice of particular miRs was based on database research (Pub-Med, Bethesda, MD, USA) taking into consideration the relationship with development of atherosclerosis and potential prognostic value. Levels of circulating miRs (miR-1-3p, miR-16-5p, miR-34a-5p, mir-122-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were compared in 142 patients with an acute ischemic event resulting from carotid and/or coronary artery stenosis, who underwent revascularization for symptomatic lesion. A 6-year prospective evaluation of CVD/MI/IS risk was performed. Patients with two-territory as compared to single-territory involvement differed in levels of miR-1-3p (p = 0.016), miR-16-5p (p < 0.001), miR-34a-5p (p = 0.018), miR-122-5p (p = 0.007), miR-124-3p (p < 0.001) and miR-499-5p (p < 0.001). During follow-up, 62 (43.7%) episodes of CVD/MI/IS occurred. In multivariate Cox analysis, miR-122-5p (HR = 1.0006, 95%CI = 1.0001–1.0011) and peripheral artery disease (PAD) (HR = 2.16, 95%CI = 1.26–3.70) were associated with CVD/MI/IS risk; miR-1-3p (HR = 2.73, 95%CI = 1.22–6.12) and PAD (HR = 3.47, 95%CI = 1.88–6.41) with CVD; miR-122-5p (HR = 1.0001, 95%CI = 1.000–1.0002) and creatinine level (HR = 1.02, 95%CI = 1.01–1.04) with IS, and miR-16-5p (HR = 1.0004, 95%CI = 1.0001–1.0008) with MI. Expression of miR-1-3p, miR-16-5p and miR-122-5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s).

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“…Recently, Dolz et al tried to construct specific circulating miRNA expression profiles in asymptomatic CAS patients by using Affymetrix microarrays, and several miRNAs were determined to be aberrantly expressed by using qRT-PCR, including miR-199b-3p, miR-27b-3p, miR-130a-3p, miR-221-3p, and miR-24-3p [ 9 ]. Another study by Badacz et al reported that several miRNAs were differentially expressed in symptomatic CAS patients compared with asymptomatic cases, the dysregulation of miRNAs showed a close association with plaque morphology and structure and might be potential prognostic factors for future cardiovascular events [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

Zhang

Zhao

et al. 2020

Diagn Pathol

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Background MicroRNAs (miRNAs) serve as novel promising biomarkers for the diagnosis and prognosis of many human diseases. This study investigated the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosis (CAS), and its predictive value for future cerebral ischemic events (CIEs). Methods Sixty-seven cases with asymptomatic CAS and 60 healthy individuals were recruited. Serum levels of miR-186-5p were tested by using qRT-PCR. Receiving–operator characteristic (ROC) curve was drawn based on sensitivity and specificity analyses. All asymptomatic CAS cases were followed up for 5 years. Kaplan-Meier method was applied for the evaluation of the predictive value of miR-186-5p for the occurrence of CIE. Results The serum level of miR-186-5p was increased significantly in asymptomatic CAS patients. MiR-186-5p was the most significant factor associated with the high degree of carotid stenosis in asymptomatic CAS patients. In the ROC curve analysis, the AUC was 0.919, with the sensitivity of 89.6% and specificity of 81.7% at the cutoff value of 1.221. Kaplan-Meier method results revealed that high miR-186-5p level was associated with the occurrence of CIEs. High miR-186-5p level and high degree of carotid stenosis were independent factors for the occurrence of CIEs. Conclusion MiR-186-5p serves as a potential diagnostic biomarker for patients with asymptomatic CAS, and predicts the occurrence of future CIEs.

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Circulating miRNA levels differ with respect to carotid plaque characteristics and symptom occurrence in patients with carotid artery stenosis and provide information on future cardiovascular events

Cited by 22 publications

References 35 publications

Inflammation‐regulatory microRNAs: Valuable targets for intracranial atherosclerosis

Inflammation‐regulatory microRNAs: Valuable targets for intracranial atherosclerosis

Expression of miR-1-3p, miR-16-5p and miR-122-5p as Possible Risk Factors of Secondary Cardiovascular Events

Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

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