Circulating MicroRNAs: What Is Their Relevance?

Hilton, Catriona; Karpe, Fredrik

doi:10.1373/clinchem.2013.203166

Cited by 17 publications

(15 citation statements)

References 15 publications

(14 reference statements)

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“…Their interaction occurs in the 3′-untranslated region (3′-UTR) of the target mRNA, causing translational repression or mRNA cleavage [ 9 ]. MiRNAs are released outside the cells into plasma and remain in circulation in a stable form, being resistant to endogenous and exogenous RNAs activity, acute pH and extreme temperature conditions [ 10 , 11 ]. This makes miRNA expression pattern to be easily detected in the peripheral blood of septic patients [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Circulating miRNAs in sepsis—A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis

et al. 2017

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Biomarkers based on the molecular mechanism of sepsis are important for timely diagnosis and treatment. A large panel of small non-coding microRNAs was reported to modulate the immune response in sepsis but have not been tested in clinical practice. Large-scale identification of microRNA networks in sepsis might reveal a new biological mechanism that can be also targeted by gene therapy. Therefore, the main objective of this study is to perform a comparison of the miRNA network between septic patients and healthy controls. We used the previously measured levels of expression of 16 different circulating human and viral microRNAs in plasma from 99 septic patients and 53 healthy controls. We used three different computational methods to find correlations between the expressions of microRNAs and to build microRNA networks for the two categories, septic patients and healthy controls. We found that the microRNA network of the septic patients is significantly less connected when compared to miRNA network of the healthy controls (21 edges vs 52 edges, P < 0.0001). We hypothesize that several microRNAs (miR-16, miR-29a, miR-146, miR-155, and miR-182) are being sponged in sepsis explaining the loss of connection in the septic patient miRNA network. This was specific for sepsis, as it did not occur in other conditions characterized by an increased inflammatory response such as in post-surgery patients. Using several target prediction instruments, we predicted potential common sponges for the miRNA network in sepsis from several signaling pathways. Understanding the dynamics of miRNA network in sepsis is useful to explain the molecular pathophysiology of sepsis and for designing therapeutic strategies that target essential components of the immune response pathways.

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Section: Introductionmentioning

confidence: 99%

Circulating miRNAs in sepsis—A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis

et al. 2017

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“…Since miRNAs changed in relation to different modes of treatment ,this finding suggests that miRNA are related to the process by which the body weight is lost rather than an effect arising for example from shrinking adipose organs [96]. Further although Ortega et al…”

Section: Role Of Circulating Micrornas In Obesity Cicrculating Mir's mentioning

confidence: 99%

An Update on Microrna?s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

Kaur¹

2015

J Health Med Inform

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“…Metabolic syndrome has an estimated prevalence of up to 34% of all adults in the USA [25]. Diseases associated with metabolic disease, including obesity, coronary artery disease, type 2 diabetes, nonalcoholic fatty liver disease, and polycystic ovarian syndrome, each have been reported to have altered microRNA expression and function [9,26,27,28,29,30,31,32,33,34,35,36]. MicroRNAs are involved in a number of metabolic processes, such as maintenance of cellular glucose, cholesterol, triglyceride, and fatty acid metabolism [37].…”

Section: Micrornas In Metabolic Diseasementioning

confidence: 99%

MicroRNA Function in Human Diseases

et al. 2013

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MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding microRNA function in human disease and the clinical significance of microRNAs. Specifically, microRNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.

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Circulating MicroRNAs: What Is Their Relevance?

Cited by 17 publications

References 15 publications

Circulating miRNAs in sepsis—A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis

Circulating miRNAs in sepsis—A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis

An Update on Microrna?s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

MicroRNA Function in Human Diseases

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