An Update on Microrna?s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

Kaur, Kulvinder Kochar

doi:10.4172/2157-7420.1000184

“…We found that the expression of miR-486-5p was significantly upregulated in MetS patients than in control subjects with highly significant correlation with WC. Moreover, former studies revealed that miR-486-5p was overexpressed in plasma of patients with visceral obesity specially children 17,18. Other studies showed that miR-486-5p was overexpressed in human and animal visceral adipose tissue compared to lean subjects 19,20.…”

Section: Discussionmentioning

confidence: 99%

<p>Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients</p>

Zaki

¹

,

Abulsoud

²

,

Elsisi

³

et al. 2019

DMSO

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Objective: This study aims to evaluate the expression pattern of circulating microRNAs (miR)-486-5p, miR-497, miR-509-5p, and miR-605 in the serum of metabolic syndrome (MetS) Egyptian male patients. Methods: In this study, the circulating miR-486-5p, miR-497, miR509-5p, and miR-605 were amplified and quantitatively detected by quantitative real-time polymerase chain reaction in sera of 55 MetS male patients in comparison to 20 male controls. The level of fasting plasma glucose and triacylglycerol (TAG) were measured using calorimetric assay. Blood pressure was measured using mercuric sphygmomanometer. Anthropometric measurements were done to each individual. Furthermore, MetS patients were defined according to the criteria proposed by the American Heart Association and divided into three groups according to MetS index. Results: The study was performed on three groups and a control group defined as follows: group 1: 15 MetS patients who fulfilled all diagnostic criteria of MetS; group 2: 20 MetS patients with normal blood pressure; group 3: 20 MetS patients with normal TAG levels.The levels of miRs are expressed as [median (IQR)]. miR-486-5-p and miR-497 expression were elevated in group 1 [31.9(49), p˂ 0.0001; 73.1(42.5), p˂ 0.0001], group 2 [36.4(15.7), p˂ 0.0001; 68.3(54.8), p˂ 0.0001], and group (3) [10.8(18.9), p= 0.0014; 27.5(39.7), p= 0.0012]. MiR-509-5p was elevated in groups 1 and 2 [501(468), p= 0.0001], [309(436), p= 0.0006], respectively, while normally expressed in group 3 [0.93(0.077), p= 0.0001]. miR-605 was elevated in groups 1 and 3 [25.4(20.0), p= 0.0018], [54.8(65.8), p˂ 0.0001], while normally expressed in group 2 [0.84(0.67), p˂ 0.0001]. Conclusion: miRs (486-5p, 497, 509-5p, and 605) serum levels were higher in MetS patients than in healthy control subjects; therefore, these serum miRs can serve as early biomarkers and can be used to follow-up the prognosis of MetS.

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“…Earlier we had reviewed different classifications and treatment strategies in addition to role of Antimullerian Hormone as an early predictor of PCOS in perimenarchal girls,part of AMH in dysfunctional folliculogenesis in addition to impairment of gonadotropin control, apart from its implication in transgenerational transfer of PCOS, role of flutamide in identification of women of Polycystic ovary syndrome[PCOS] at risk for generation of Metabolic disease in normal weight PCOS ,role of kisspeptins answer the modes by which transgenerational transmission of Polycystic ovary syndrome [PCOS] occurs to find a way of avoidance of inheritance of PCOS [15][16][17][18][19][20][21][22][23][24][25][26][27][28].Here we considered how this knowledge might be applied of browning of WAT in treating PCOS.…”

Section: Adipose Tissue [At] Inclusive Of White Adipose Tissue [Wat] ...mentioning

confidence: 99%

Untitled

2023

AYPT

0

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Brown adipose tissue(BAT)portrays a specialized tissue, possessing a crucial part in metabolism as well as energy expenditure(EE) via adaptive non shivering thermogenesis .Recently it has assumed a significant part in the treatment of obesity along with metabolic disease.The thermogenesis action of BAT is brought about by uncoupling protein1 (UCP1 ),that uncouples adenosine triphosphate (ATP) generation from oxidation of energy substrates.Having reviewed earlier various aspects pf Polycystic ovary syndrome (PCOS) pathophysiology,treatment,role in trans generational PCOS transferalong with role of BAT pathophysiology,beige/brite adipocytes in the treatment of obesity along with metabolic disease here we decided to further evaluate the possible part of BAT in PCOS. Thus anarrative review was carried out using the pubmed, Web of Science , Medline, Embase, Cochrane reviews, and Google Scholar, Search engine with the MeSH Terms;PCOS; impaired lipid metabolism; Brown Adipose tissue (BAT); White Adipose tissue(WAT); oxidative stress;inflammation;obesity ;T2DM); Type 1 diabetes (T1D); role of natural substances for PCOStherapy like rutin ,berberine;resveratrol ; weight reduction; browning of WAT ;Macrophage Polarization from 1990 till date in 2023.We found a total of 250 articles ,out of which we selected. 100 articles for this review. No meta-analysis was done. The endocrine action of brown Adipocytes impacts the energy balanceof glucose as well as lipid homeostasis thus impacting the correlation of BAT activity along with metabolic profile. PCOS mirrors a complicated reproductive as well asmetabolic condition of women in their reproductive age. Fcapital aberrations in adipose tissue have been illustrated in PCOS patients. Multiple studies have illustrated that BAT possesses the capacity of controlling the properties of PCOS as well as escalating BAT mass/activity were efficacious in the therapy of PCOS. Via cold stimulation, BAT transplantation as well as activationwith substances like rutin aypoglycemiaX along with as well as

show abstract

“…Earlier we had reviewed different classifications and treatment strategies in addition to role of Antimullerian Hormone as an early predictor of PCOS in perimenarchal girls,part of AMH in dysfunctional folliculogenesis in addition to impairment of gonadotropin control, apart from its implication in transgenerational transfer of PCOS, role of flutamide in identification of women of Polycystic ovary syndrome[PCOS] at risk for generation of Metabolic disease in normal weight PCOS ,role of kisspeptins answer the modes by which transgenerational transmission of Polycystic ovary syndrome [PCOS] occurs to find a way of avoidance of inheritance of PCOS [15][16][17][18][19][20][21][22][23][24][25][26][27][28].Here we considered how this knowledge might be applied of browning of WAT in treating PCOS.…”

Section: Adipose Tissue [At] Inclusive Of White Adipose Tissue [Wat] ...mentioning

confidence: 99%

‘’Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatment-still long time to reach clinical arena: a narrative review’’

2023

AYPT

0

View full text Add to dashboard Cite

Brown adipose tissue(BAT)portrays a specialized tissue, possessing a crucial part in metabolism as well as energy expenditure(EE) via adaptive non shivering thermogenesis .Recently it has assumed a significant part in the treatment of obesity along with metabolic disease.The thermogenesis action of BAT is brought about by uncoupling protein1 (UCP1 ),that uncouples adenosine triphosphate (ATP) generation from oxidation of energy substrates.Having reviewed earlier various aspects pf Polycystic ovary syndrome (PCOS) pathophysiology,treatment,role in trans generational PCOS transferalong with role of BAT pathophysiology,beige/brite adipocytes in the treatment of obesity along with metabolic disease here we decided to further evaluate the possible part of BAT in PCOS. Thus anarrative review was carried out using the pubmed, Web of Science , Medline, Embase, Cochrane reviews, and Google Scholar, Search engine with the MeSH Terms;PCOS; impaired lipid metabolism; Brown Adipose tissue (BAT); White Adipose tissue(WAT); oxidative stress;inflammation;obesity ;T2DM); Type 1 diabetes (T1D); role of natural substances for PCOStherapy like rutin ,berberine;resveratrol ; weight reduction; browning of WAT ;Macrophage Polarization from 1990 till date in 2023.We found a total of 250 articles ,out of which we selected. 100 articles for this review. No meta-analysis was done. The endocrine action of brown Adipocytes impacts the energy balanceof glucose as well as lipid homeostasis thus impacting the correlation of BAT activity along with metabolic profile. PCOS mirrors a complicated reproductive as well asmetabolic condition of women in their reproductive age. Fcapital aberrations in adipose tissue have been illustrated in PCOS patients. Multiple studies have illustrated that BAT possesses the capacity of controlling the properties of PCOS as well as escalating BAT mass/activity were efficacious in the therapy of PCOS. Via cold stimulation, BAT transplantation as well as activationwith substances like rutin aypoglycemiaX along with as well as

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An Update on Microrna?s and Metabolic Regulation with Future Therapeutic Potentials Regarding Diagnosis and Treatment of Obesity, Metabolic Syndrome and Other Related Disorders

Cited by 7 publications

References 179 publications

<p>Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients</p>

<p>Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients</p>

Untitled

‘’Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatment-still long time to reach clinical arena: a narrative review’’

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