Circulating microparticles levels are increased in patients with diabetic kidney disease: A case-control research

Rodrigues, Kathryna Fontana; Pietrani, Nathalia Teixeira; Fernandes, Ana Paula; Bosco, Adriana; Sousa, Maira Cândida Rodrigues de; Silva, Iêda de Fátima Oliveira; Silveira, Josianne Nicácio; Campos, Fernanda Magalhães Freire; Gomes, Karina Braga

doi:10.1016/j.cca.2017.12.048

Cited by 27 publications

(24 citation statements)

References 44 publications

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“…In line with our results, Rodrigues et al demonstrated elevated levels of EMVs (CD51 + /AV + ) in a cohort of T2DM patients with nephropathy, 23 and EMVs (CD31 + / AV + ) were found increased in patients with microalbuminuria or macroalbuminuria, compared to those without albuminuria. 24 Furthermore, increased ratio of EMVs to EPCs was shown to be associated with reduced glomerular filtration rate (GFR), indicating that an imbalance in endothelial damage and repair capacity may in part explain reduced renal function.…”

Section: Discussionsupporting

confidence: 93%

Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training

Bratseth

Chiva‐Blanch²,

Byrkjeland

et al. 2019

Diabetes and Vascular Disease Research

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Objective:Circulating microvesicles, released from activated/apoptotic cells, are involved in vascular complications and may be looked upon as biomarkers. Albuminuria is characteristic of disease progression in type 2 diabetes mellitus. We aimed to investigate quantitative and qualitative differences of circulating microvesicles in type 2 diabetes mellitus with and without albuminuria and whether 12-month exercise training influenced expression of circulating microvesicles.Methods:Coronary artery disease patients with type 2 diabetes mellitus (n = 75), of which 25 had albuminuria, were included. Annexin V+(AV+) circulating microvesicles were analysed by flow cytometry in citrated plasma. The exercise volume was 150 min per week.Results:In albuminuria patients, circulating microvesicles from endothelial-(CD146+/CD62E+/AV+) and endothelial-progenitor-(CD309+/CD34+/AV+) cells were significantly higher compared to those without ( p ⩽ 0.01, both). Receiver operating characteristic curve analysis of the endothelial circulating microvesicles shows an area under the curve of 0.704 (95% confidence interval: 0.57–0.84; p = 0.004). Albuminuria patients had more circulating microvesicles derived from activated leukocytes and monocytes and monocytes carrying tissue factor (CD11b+/AV+, CD11b+/CD14+/AV+, CD142+/CD14+/AV+, respectively, p ⩽ 0.05, all) and higher number of circulating microvesicles from activated platelets (CD62P+/AV+). Within exercising patients, circulating microvesicles from progenitor cells increased ( p = 0.023), however, not significantly different from controls.Conclusion:Coronary artery disease patients with type 2 diabetes mellitus and albuminuria had elevated number of circulating microvesicles from activated blood and vascular cells, rendering them as potential predictors of disease severity. The circulating microvesicles were limitedly affected by long-term exercise training in our population.

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Section: Discussionsupporting

confidence: 93%

Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training

Bratseth

Chiva‐Blanch²,

Byrkjeland

et al. 2019

Diabetes and Vascular Disease Research

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“…Activated or apoptotic ECs, if damaged, release endothelial microparticles that we can view as circulating markers [ 42 ]. It has been demonstrated that circulating total microparticles are greatly elevated in patients with T2DM, suggesting that changing microparticle levels are possibly relevant to diabetic conditions [ 43 ], thus opening a new scenario for future investigations. Recently, it has also been demonstrated that Sterol regulatory element-binding protein 1 (SREBP1)—an important transcriptional regulator of lipogenesis [ 44 ], regulated by Sec23A [ 45 ]—is involved in the modulation of insulin resistance and in the lipogenesis that is chronically enhanced diabetes, thus laying the foundation for the development of novel future therapeutic strategies to contain the onset of diabetes.…”

Section: Endothelial Dysfunction and Diabetesmentioning

confidence: 99%

The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation

Carrizzo

Izzo

Oliveti

et al. 2018

IJMS

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Diabetes mellitus is a common disease that affects 3–5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6–8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients. In this review, we try to describe in an organized way the pathophysiological continuity between diabetes mellitus, endothelial dysfunction, and platelet hyperaggregation, highlighting the main molecular mechanisms involved and the interconnections.

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“…Circulating EVs, although to a lesser extent than uEVs, have been also investigated as biomarkers for DKD diagnosis. In this regard, increased levels of platelet-, erythrocyte-, leukocyte-, and endothelial-derived EVs have been reported in DKD patients compared to controls [ 93 , 94 , 95 ]. The role of platelet-derived EVs in GEC dysfunction was also investigated in an experimental model of streptozotocin-induced diabetes in rats by Zhang Y et al [ 96 ].…”

Section: Circulating Evs In Diabetic Kidney Diseasementioning

confidence: 99%

Urinary Extracellular Vesicles for Diabetic Kidney Disease Diagnosis

Saenz-Pipaon

Echeverria

Orbe

et al. 2021

JCM

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Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in developed countries, affecting more than 40% of diabetes mellitus (DM) patients. DKD pathogenesis is multifactorial leading to a clinical presentation characterized by proteinuria, hypertension, and a gradual reduction in kidney function, accompanied by a high incidence of cardiovascular (CV) events and mortality. Unlike other diabetes-related complications, DKD prevalence has failed to decline over the past 30 years, becoming a growing socioeconomic burden. Treatments controlling glucose levels, albuminuria and blood pressure may slow down DKD evolution and reduce CV events, but are not able to completely halt its progression. Moreover, one in five patients with diabetes develop DKD in the absence of albuminuria, and in others nephropathy goes unrecognized at the time of diagnosis, urging to find novel noninvasive and more precise early diagnosis and prognosis biomarkers and therapeutic targets for these patient subgroups. Extracellular vesicles (EVs), especially urinary (u)EVs, have emerged as an alternative for this purpose, as changes in their numbers and composition have been reported in clinical conditions involving DM and renal diseases. In this review, we will summarize the current knowledge on the role of (u)EVs in DKD.

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Circulating microparticles levels are increased in patients with diabetic kidney disease: A case-control research

Abstract: These results suggest that type 2 diabetes mellitus patients with DKD presented higher circulating MPs levels - PMPs, LMPs, EMPs, and TFMPs - which correlated with metabolic alterations.

Cited by 27 publications

References 44 publications

Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training

Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training

The Main Determinants of Diabetes Mellitus Vascular Complications: Endothelial Dysfunction and Platelet Hyperaggregation

Urinary Extracellular Vesicles for Diabetic Kidney Disease Diagnosis

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