Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases

Dou, Xuelin; Wang, Ren-Ben; Huang, Yan; Jiang, Suping; Meng, Xiangjiao; Zhu, Kangshun; Xu, Xiaoqing; Mu, Dianbin

doi:10.7314/apjcp.2013.14.6.3881

Cited by 39 publications

(31 citation statements)

References 27 publications

(28 reference statements)

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“…Furthermore, it has been reported that the NLR is correlated with the pathological response to preoperative therapy (35,36). However, there have been no reports focusing on the association between high NLR and poor response to neoadjuvant therapies in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In cases where combined therapies are used, it is essential to identify predictors of response to preoperative therapy in order to inform the assessment of risk and patient counselling. Similar multimodal therapies have been used for the treatment of esophageal and rectal cancers, as well as pancreatic cancer; NLR has been reported to be a useful and available predictive marker associated with pathological response to neoadjuvant chemotherapy or preoperative chemoradiotherapy in esophageal and rectal cancers, respectively (35,36). However, to the best of our knowledge, the present study is the first to demonstrate that pre-treatment NLR is significantly higher in pancreatic cancer patients who respond poorly to treatment compared with that of patients who exhibit a favorable response.…”

Section: Discussionmentioning

confidence: 99%

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Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

et al. 2015

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“…Cellular immune response decreased as a consequence of lymphocytopenia. Recent studies showed that decreased tumor infiltrating T cells have been associated with poor prognosis in some cancers (Walsh et al, 2005;Fogar et al, 2006;Bhatti et al, 2010;Dou et al, 2013). Due to all these effects of inflammation lead to the NLR increase in peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

Özyalvaçlı¹,

Yesil²,

Karğı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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IntroductionsBreast cancer is the most common type of cancer in women and the risk increases with age. As in other tumors the development of breast carcinoma is associated with systemic inflammation. The systemic inflammatory response can change with tumor growth, invasion, angiogenesis and metastasis. İnflammatory markers such as c reactive protein (CRP) and interleukin 6 (IL 6) are increased in breast cancer patients and a have adverse effect on survey (Balta et al., 2013).Benign proliferative breast disease (BPBD) is most common in women who are in their thirties to fifties. Various sizes of cysts, adenosis, hyperplasia with atypia and/or without atypia and apocrine metaplasia can be seen in BPBD on microscopic examination. Despite the strong association between BPBD and breast cancer development, the exact causes of BPBD are still unknown. Hormonal imbalance especially increased estrogen via to progestin is thought to play a role in development of BPBD. Breast cancer risk related with proliferative breast disease. Several studies showed that inflammation plays an important role in the development of BPBD and early breast carcinogenesis (Catsburg et al., 2014).Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al., 2013). AbstractBackground: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. Materials and Methods: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). Results: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. Conclusions: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.

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“…And tumor growth is to induce Tc increase, thus there is a positive feedback model between Tc cell increase and tumor growth (Mitropoulos et al, 1995). It is suggested that CD4+/CD8+ ratio is crucial to be kept in a dynamic balance, in terms of maintaining the immunological function stable (Dou et al, 2013). the ratio decreased is reported to link with a low immunological function (Erdem et al, 2012;Nugroho et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

Wang

Tao²,

Gu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases

Cited by 39 publications

References 27 publications

Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

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