Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

Wang, Wenjing; Tao, Zhen; Gu, Wei; Sun, Le

doi:10.7314/apjcp.2013.14.8.4671

Cited by 30 publications

(27 citation statements)

References 13 publications

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“…Adenocarcinoma is the most common histologic subtype of lung cancer in most countries [3]. The low antitumor response had been thought to contribute to the occurrence and development of lung cancer [4,5,6]. However, the precise mechanisms underlying the suppression of the antitumor response in lung adenocarcinoma are not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

Huang

Tan

et al. 2015

International Immunopharmacology

167

124

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Section: Introductionmentioning

confidence: 99%

Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

Huang

Tan

et al. 2015

International Immunopharmacology

167

124

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“…The expression of regulatory T cell (Treg) specific transcription factors such as Foxp3 (Costantino et al, 2008;Wang et al, 2013) was not assessed in this study. However, the rather low percentage of CD4+CD25+ T cells [(0.73±1.33)%] implied that the proportion of Treg cells was extremely low in EAAL cells.…”

Section: Discussionmentioning

confidence: 99%

Adoptive Immunotherapy for Small Cell Lung Cancer by Expanded Activated Autologous Lymphocytes: a Retrospective Clinical Analysis

Zhang

Li²,

Sun³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To investigate the clinical efficacy of expanded activated autologous lymphocytes (EAAL) in patients with small cell lung cancer (SCLC). Materials and Methods: A total of 32 SCLC patients were selected and randomly divided into EAAL treatment and control groups, 16 cases in each. EAAL were obtained by proliferation of peripheral blood mononuclear cells (PBMCs) of patients followed by phenotype determination. Clinical data of all patients were recorded. Patients of both groups were followed up and the overall survival (OS) were compared retrospectively. Results: After culture and proliferation in vitro, the percentages of CD3 + , CD3 + CD8 + , CD45RO + , CD28 + , CD29 + , CD8 + CD28 + and CD3+CD16+/CD56+ cells increased markedly (p<0.05). The OS of the EAAL treatment group was longer than that of control group, but the difference was not statistically significant (p=0.060, HR=0.487, 95%CI 0.228~1.037). 1-to 3-year survival rates in EAAL treatment group were longer than those in control group, but there was still no significant difference (p>0.05). COX multivariate regression analysis showed that the number of chemotherapy cycles and the application of EAAL immunotherapy were independent prognostic factors for SCLC patients. The OS in females and chemotherapy≤6 cycles were obviously prolonged after EAAL immunotherapy. Conclusions: In vitro induction and proliferation of EAAL is easy and biologically safe. Generally, EAAL adoptive immunotherapy can evidently prolong the OS of SCLC patients.

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“…In this study, The patients with OSCC received 2 cycles CT or radical operation had a significantly higher level of CD4 + /CD8 + ratio compared with that received no treatment or 1 cycle CT. NK cell is also designated as natural killer cells. NK cell could directly destroy tumor cells, and reduced level of NK cell will lead to decline of immunological function (Wang et al 2013 ). Our results showed that there is no difference of expression of CD3 – CD16 + CD56 + NK cell in OSCC patients received different treatments, suggesting no significant influence of different treatments of NK cells on patients with OSCC.…”

Section: Discussionmentioning

confidence: 99%

The role of chemotherapy and operation on lymphocytes accumulation in peripheral blood obtained from patients with oral squamous cell carcinoma

Guo

et al. 2015

SpringerPlus

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The “Cancer Immunoediting” concept has provided critical insights suggesting dual functions of immune system during the cancer initiation and development. However, the dynamics and roles of CD4+ and CD8+ T cells, CD19+ B cells, and CD56+ NK cells in the patients with oral squamous cell carcinoma during treatment remain unclear. A total of 43 patients with OSCC were divided into different groups according to different clinical factors (TNM staging, pathological patterns, age and genders) for assessment of relations with CD3+CD4+ T cells, CD3+CD8+ T cells, CD3−CD19+ B cells and CD3−CD16+CD56+ NK cells and different chemotherapy and radical operation. The expression of CD3+CD4+ T cells were significantly increased in advanced tumor stage, large tumor size and positive lymph nodes metastasis, compared to that in early groups. The accumulation of CD3+CD4+ T cells were significantly increased in OSCC patients received 2 cycles CT and radical operation. Moreover, the accumulation of CD3+CD8+ T cells were significantly decreased in OSCC patients received 2 cycles CT and radical operation. The distribution of circulating CD3−CD19+ B cells was related with radical operation in patients with OSCC. This study indicate that CD4+ T cells have opposing roles in OSCC progression and outcomes, which provides new insights relevant for the development of effective cancer immunotherapeutic approaches. 2 cycles TP regime chemotherapy and radical therapy may contribute to increase the effects of anti-tumor immunity on patients with OSCC.

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Variation of Blood T Lymphocyte Subgroups in Patients with Non- small Cell Lung Cancer

Cited by 30 publications

References 13 publications

Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma

Adoptive Immunotherapy for Small Cell Lung Cancer by Expanded Activated Autologous Lymphocytes: a Retrospective Clinical Analysis

The role of chemotherapy and operation on lymphocytes accumulation in peripheral blood obtained from patients with oral squamous cell carcinoma

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