Circulating levels of plasma lipids and cardiovascular risk in Nigerian women with severe preeclampsia

Udenze, Ifeoma; Okusanya, Babasola O; Soriyan, Oyetunji OyetunjiO; Ajie, Iwuchukwu O.; Egbuagha, E U

doi:10.4103/2408-7408.179680

Cited by 2 publications

(3 citation statements)

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“…TG play a role as regulators in lipoprotein interactions. This is supported by evidence that an increase in plasma concentration is associated with an increased incidence of coronary artery disease, an increase in the number of VLDL cholesterol particles and an increase in the potential for the transfer of a cholesterol ester mass from HDL cholesterol to a lipoprotein containing apolipoprotein [24], [25].…”

Section: Discussionmentioning

confidence: 92%

“…Preeclampsia women had abnormal lipid results. Limited data regarding the effects of high blood pressure on lipid levels but new-onset preeclampsia triggers an increase in atherogenic lipid parameters with a decrease in cardioprotective HDL [25]. Barry et al in his study stating that uncomplicated postpartum women, visceral fat correlated independently with insulin sensitivity, blood pressure, and phenotypes of atherogenic lipoproteins whereas BMI and total body fat were not related.…”

Section: Discussionmentioning

confidence: 99%

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Differences of Cardiovascular Risk-based on Atherogenic Index Plasma Dan Framingham Risk Score in Postpartum with Preeclampsia and Normotensive

Siregar

Sitepu

Tala

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Cardiovascular disease is the number one cause of death in women worldwide. Preeclampsia may be more than just risk factor for the development of cardiovascular disease later in life. Systematic reviews suggested approximately double the risk of ischemic heart disease, cerebrovascular incidents, and mortality of cardiovascular disease after preeclampsia. AIM: The aim of the study was to analyze the differences of cardiovascular risk later in life-based on atherogenic index plasma and Framingham risk score (FRS) in postpartum women with preeclampsia compared with normotensive women. METHODS: This is study a comparative analytic study with case–control design on 46 subjects, divided by 23 postpartum preeclampsia patients as a case sample subject and 23 postpartum with no history of hypertension as the control group. Subjects were examined for blood pressure, height, weight, and asked to fast for at least 8 h before blood lipid profile and glucose were examined with laboratory methods. Atherogenic index plasma and FRS were measured. Data were analyzed using SPSS version 25. p < 0.05 was considered significant. RESULTS: Based on the results, the study found significant differences between systolic and diastolic blood pressure in preeclampsia compared to the control group. Median systolic and diastolic blood pressure in the preeclampsia group compared to control group were 180 versus 110 in systolic blood pressure; 100 versus 80 in diastolic blood pressure with p < 0.000. Total cholesterol, low-density lipid, high-density lipoprotein, and triglycerides levels in preeclampsia were 218.38 ± 23.26 mg/dL, 128.60 ± 22.74 mg/dL, 38.60 ± 5.99 mg/dL, and 252.73 ± 47.16 mg/dL, respectively, with p < 0.05 and non-preeclampsia group were 143.0 ± 16.82 mg/dL, 69.17 ± 23.03 mg/dL, 51.73 ± 8.65 mg/dL, and 121.30 ± 14.65 mg/dL, respectively, with p < 0.05. Differences in plasma atherogenic index values can clearly be observed in the preeclampsia and control groups (p < 0.05). A similar interpretation was found in the FRS (p < 0.05). There was a significant positive correlation between age and body mass index with atherogenic index plasma and FRS in preeclamptic group. CONCLUSION: There was a significant difference in atherogenic index plasma and Framingham risk score of postpartum preeclampsia and normotensive women.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Differences of Cardiovascular Risk-based on Atherogenic Index Plasma Dan Framingham Risk Score in Postpartum with Preeclampsia and Normotensive

Siregar

Sitepu

Tala

et al. 2020

Open Access Maced J Med Sci

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show abstract

“…Udenze dkk (2016) pada penelitiannya menjelaskan bahwa pada pasien ibu hamil dengan preeklamsia berat mengalami peningkatan kadar triasilgliserol, LDL, dan kolesterol total serta penurunan kadar HDL. 10 Ahmed dkk (2018) juga menemukan keadaan hipertrigliseridemia pada ibu hamil dengan preeklampsia yang disertai dengan peningkatan kadar kolesterol total, LDL, dan VLDL serta penurunan HDL. Pada penelitiannya, Ahmed dkk menjelaskan bahwa semakin berat preeklampsia yang dialami akan berkaitan dengan semakin tinggi kadar trigliserida, kolesterol, LDL, dan VLDL serta menurunnya kadar HDL.…”

Section: Hasilunclassified

Gangguan Fungsi Ginjal Pada Ibu Hamil Preeklampsia Berat Dengan Dislipidemia Di Rsud Kelas B Serang

Amalia¹,

Harfiani²,

Chairani³

2020

kespro

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Abstract Background: Preeclampsia is one of the leading causes of maternal-fetal morbidity and mortality in developing countries. Dyslipidemia in severely preeclamptic women will develop end-organ damage due to endothelial dysfunction. Objective: The objective of this study was to evaluate the correlation between blood lipid profile and renal function in severely preeclamptic women at RSUD Class B Serang district, January-December 2018. Method: This study was an analytical observational study with a cross-sectional design. Conducted using total sampling technique, 103 pregnant women were included from medical records. Data were analyzed using correlation tests and logistic regression. Result: Correlation analysis indicates that HDL level (<60mg/dL) and LDL level (>160 mg/dL) had a significant impact in the alteration of urea and creatinine level in severe PE. Logistic regression analysis signifies that only decreased level of HDL had a significant partial impact on increasing creatinine levels (p=0,013 OR=1,107). Conclusion: The conclusion of this study was in severe PE women there was an increased level of TG and LDL, with a decreased level of HDL. Dyslipidemia in severe PE women will lead to oxidative stress and endothelial dysfunction, which further will cause alteration in glomerulus structure and disturbance of renal function. Keywords: dyslipidemia, creatinine, severe PE, urea Abstrak Latar Belakang: Preeklampsia (PE) merupakan salah satu penyebab utama kesakitan dan kematian ibu dan bayi di negara berkembang. Dislipidemia pada ibu hamil dengan preeklampsia berat (PEB) akan menyebabkan end-organ damage akibat disfungsi endotel. Tujuan: Tujuan penelitian ini adalah untuk menilai hubungan antara profil lipid darah terhadap gangguan fungsi ginjal pada ibu hamil dengan preeklampsia berat di RSUD Kelas B Serang periode Januari – Desember 2018. Metode: Penelitian ini merupakan penelitian observasi analitik dengan pendekatan cross sectional. Menggunakan teknik total sampling, sebanyak 103 sampel diambil dari data rekam medik. Data dianalisis menggunakan uji korelasi dan regresi logistik. Hasil: Hasil korelasi menunjukkan bahwa kadar HDL yang lebih rendah (<60 mg/dL) dan kadar LDL yang lebih tinggi (>160 mg/dL) memiliki hubungan yang bermakna terhadap peningkatan kadar ureum dan kreatinin pada bumil dengan PEB. Analisis regresi logistik memperlihatkan bahwa hanya kadar HDL yang menurun memiliki hubungan parsial yang signifikan terhadap peningkatan kadar kreatinin (p=0,013 OR=1,107). Kesimpulan: Kesimpulan penelitian ini bahwa telah ditemukan peningkatan kadar trigliserida (TG) dan LDL serta penurunan kadar HDL pada bumil dengan PEB. Dislipidemia pada PEB akan menyebabkan stres oksidasi dan disfungsi endotel yang selanjutnya akan menyebabkan perubahan struktur glomerulus dan perubahan fungsi ginjal Kata kunci: dislipidemia, kreatinin, PEB, ureum

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Circulating levels of plasma lipids and cardiovascular risk in Nigerian women with severe preeclampsia

Cited by 2 publications

References 2 publications

Differences of Cardiovascular Risk-based on Atherogenic Index Plasma Dan Framingham Risk Score in Postpartum with Preeclampsia and Normotensive

Differences of Cardiovascular Risk-based on Atherogenic Index Plasma Dan Framingham Risk Score in Postpartum with Preeclampsia and Normotensive

Gangguan Fungsi Ginjal Pada Ibu Hamil Preeklampsia Berat Dengan Dislipidemia Di Rsud Kelas B Serang

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