Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer

Fryczkowski, Michal; Bułdak, Rafał Jakub; Hejmo, Tomasz; Kukla, Michał; Żwirska-Korczala, K

doi:10.1155/2018/3852401

Cited by 33 publications

(31 citation statements)

References 72 publications

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“…Several related researches reported that altered circulating concentrations of omentin-1 in colorectal cancer and renal cell cancer patients, which indicated that omentin-1 might play a potential role in carcinogenesis 17,18. However, to our knowledge, plasma omentin-1 levels in PCa were rarely explored, especially in Asian population 19,20. Herein, we conducted this case-control study to test the plasma omentin-1 levels in PCa in Chinese population and to explore its potential role in diagnosing PCa patients.…”

Section: Introductionmentioning

confidence: 96%

<p>Altered circulating levels of adipokine omentin-1 in patients with prostate cancer</p>

Zhou¹,

Wang³

et al. 2019

OTT

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Background: Prostate cancer (PCa), one of the most common cancers in men, accounts for nearly 20% of adult malignant neoplasms. Omentin-1 is synthesized in visceral adipose tissue and its concentration in plasma changes with cancers. However, the association between omentin-1 and PCa was rarely studied. Thus, we investigated the plasma omentin-1 levels in PCa patients in Chinese population. Materials and methods: Ninety cases of PCa and 90 matched healthy controls were enrolled in this study. We used ELISA technique to determine the concentration of omentin-1. Results: The concentration of omentin-1 was higher in patients with PCa compared to controls ( P <0.001). Additionally, positive correlations were uncovered between omentin-1 with body mass index (r=0.240, P =0.001), waist-hip ratio (r=0.228, P =0.002), and prostate-specific antigen (r=0.589, P <0.001). Receiver operating characteristic curve analysis indicated that plasma omentin-1 differentiated PCa patients from controls with a sensitivity of 85.9% and a specificity of 83.7%. Conclusion: Our study demonstrated that the levels of plasma omentin-1 were increased in PCa patients. Meanwhile, omentin-1 may be a possible biomarker for diagnosing PCa. For validation, more studies should focus on and elucidate the potential mechanism underlying this change.

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Section: Introductionmentioning

confidence: 96%

<p>Altered circulating levels of adipokine omentin-1 in patients with prostate cancer</p>

Zhou¹,

Wang³

et al. 2019

OTT

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“…It accounts for approximately 15% of all diagnosed cancers (Ferlay et al, 2012). In addition, PCa is the second most common cause of cancer deaths in men (Heidenreich et al, 2011). Testosterone and some other hormones are known to play a role in the etiology of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, adipokine levels may be useful for cancer diagnosis and prognosis. On the other hand, changes in the secretion of adipokines have been reported to be closely associated with prostate cancer (Fryczkowski et al, 2018;Hu et al, 2019).…”

Section: Can the Irisin Be A Biomarker For Prostate Cancer? A Case Comentioning

confidence: 99%

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Aslan

Hakan

Eryılmaz

et al. 2020

Asian Pac J Cancer Prev

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Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cutoff value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA.

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“…The vascular endothelial growth factor (VEGF) family is considered to play an important role in the carcinogenesis and progression of PC [116,117]. An animal model implanted with androgen-sensitive human PC cells (CWR22Rv1 cells) showed that the oral intake of GTP decreased the expression levels of VEGF in tumors [39].…”

Section: Anti-cancer Effects Of Green Tea At the Molecular Levelmentioning

confidence: 99%

Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer

et al. 2019

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Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding these anti-cancer effects. In recent years, in addition to prevention, many investigators have shown the efficacy and safety of green tea polyphenols and combination therapies with green tea extracts and anti-cancer agents in in vivo and in vitro studies. Furthermore, numerous studies have revealed the molecular mechanisms of the anti-cancer effects of green tea extracts. We believe that improved understanding of the detailed pathological roles at the molecular level is important to evaluate the prevention and treatment of prostate cancer. Therefore, in this review, we present current knowledge regarding the anti-cancer effects of green tea extracts in the prevention and treatment of prostate cancer, with a particular focus on the molecular mechanisms of action, such as influencing tumor growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors. Finally, the future direction for the use of green tea extracts as treatment strategies in patients with prostate cancer is introduced.

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Circulating Levels of Omentin, Leptin, VEGF, and HGF and Their Clinical Relevance with PSA Marker in Prostate Cancer

Cited by 33 publications

References 72 publications

<p>Altered circulating levels of adipokine omentin-1 in patients with prostate cancer</p>

<p>Altered circulating levels of adipokine omentin-1 in patients with prostate cancer</p>

Can the Irisin be a Biomarker for Prostate Cancer? A Case Control Study

Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer

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