Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function

Teixeira, Antônio Lúcio; Barbosa, Izabela Guimarães; Diniz, Breno S.; Kümmer, Arthur

doi:10.2217/bmm.10.111

Cited by 134 publications

(91 citation statements)

References 215 publications

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“…Plasma and partially serum, BDNF levels were modified in several diseases and conditions such as: fibromyalgia [increased (196)], hemodialysis [increased, especially in diabetic patients (197)], metabolic syndrome and T2DM [increased (198)], bipolar disorder [decreased (199)], as well as with mood, cognition and motor function (200), alcohol consumption [decreased (201)], antidepressant treatments [increased (202)]. …”

Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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“…This study, specifically, failed to show significant differences between ALS patients and a group of lumbar disc disease controls. On the other hand, circulating levels of BDNF were found altered in several neurological and psychiatric disorders [27]. Lower BDNF serum levels were shown, for example, in frontotemporal lobar degeneration patients versus healthy controls, but not Alzheimer disease patients [28], while people with lower serum BDNF were found to be at higher risk of developing Alzheimer disease in a large population-based study [29].…”

Section: Introductionmentioning

confidence: 99%

BDNF Serum Levels with Respect to Multidimensional Assessment in Amyotrophic Lateral Sclerosis

et al. 2016

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Background: The clinical presentation of amyotrophic lateral sclerosis (ALS) is characterized by high heterogeneity, the greatest part of which still remains unexplained. Objective: To assess serum levels of brain-derived neurotrophic factor (BDNF) in ALS patients, implementing a multidimensional characterization focused on four a priori chosen elements of phenotypic variability: ALS bulbar/spinal subtype, cognitive impairment, mood dysfunction and disease progression speed. Methods: Serum samples were obtained from 45 ALS outpatients (16% bulbar onset) and 22 healthy controls. Each patient underwent the Montreal Cognitive Assessment (MoCA) and the Beck Depression Inventory (BDI), and disease progression speed was estimated by calculating the decay of the ALSFRS-R score over time. Results: BDNF serum levels did not differ between patients and controls, although ∼25% lower levels characterized those patients carrying a depressive trait. Finally, BDNF serum levels were significantly lower in ALS patients expressing lower ALSFRS-R scores (r = 0.39, p < 0.01). No differences were found when considering cognitive impairment, disease progression speed and site of onset. Conclusion: BDNF serum levels might mark and possibly contribute in part to ALS phenotypic variability.

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“…Several lines of evidence suggest a widespread abnormality in neurotrophic cascades in age-related neuropsychiatric disorders, such as Alzheimer's disease and late-life depression (Teixeira et al, 2010). Most data derive from studies assessing circulating levels of BDNF and NGF, showing a significant reduction of circulating neurotrophins in these patients which correlates with the stage of cognitive impairment and the severity of depressive symptoms (Forlenza et al, 2010a, b;Yu et al, 2008;Diniz et al, 2010a).…”

Section: Introductionmentioning

confidence: 99%

Circulating Glial-derived neurotrophic factor is reduced in late-life depression

Diniz

Teixeira

Talib

et al. 2012

Journal of Psychiatric Research

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Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function

Cited by 134 publications

References 215 publications

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

BDNF Serum Levels with Respect to Multidimensional Assessment in Amyotrophic Lateral Sclerosis

Circulating Glial-derived neurotrophic factor is reduced in late-life depression

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