Circulating Glial-derived neurotrophic factor is reduced in late-life depression

Diniz, Breno S.; Teixeira, Antônio Lúcio; Talib, Leda Leme; Gattaz, Wagner F.; Forlenza, Orestes Vicente

doi:10.1016/j.jpsychires.2011.09.007

Cited by 60 publications

(41 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GDNF is also resistant to repeated freeze/thaw cycles (204). Plasma GDNF concentrations have been associated with mood state, bipolar disorder and age [increased (205)], late-life depression [reduced (206)], adolescent depression [decreased (207)], attention deficit [increased (208)]. …”

Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

View full text Add to dashboard Cite

Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

show abstract

Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

View full text Add to dashboard Cite

show abstract

“…However, findings related to GDNF levels are inconsistent. Decreased peripheral levels of GDNF in depression [13,67,80] and bipolar disorders either in depressive or manic episodes [7,67] and reduced GDNF expression in depression [55], contrary, increased GDNF levels in cortical areas in depressive Background: Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) have essential roles in synaptic plasticity which is involved in pathogenesis and treatment of psychiatric disorders. However, it is not clear whether they act simultaneously during illness states in major psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Patients with TTH had more anxiety and depressive symptoms than controls. NF levels have been previously correlated with depression and anxiety disorders 16,17,18,19,20 . Despite this, there were no significant correlations among NF levels and anxiety and depression scores, and TTH patients with moderate anxiety and depression scores had not altered NF levels.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophic factors in tension-type headache

Domingues

Duarte

Rocha

et al. 2015

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

Tension-type headache (TTH) is the most prevalent headache and is associated with a high socioeconomical impact 1 . It has been suggested that episodic TTH (ETTH) is mainly due to peripheral mechanisms such as muscle tenderness. Central mechanisms leading to reduced pain threshold and sensitization in the trigeminal nucleus, thalamus, or somatosensory cortex are probably related with chronic TTH (CTTH) 2 . However, the precise mechanisms determining ETTH and the conversion of ETTH to CTTH remain largely unknown.Neurotrophic factors (NF) are a unique group of polypeptides responsible for neuron survival, axon growth, dendrite prunning, and the expression of essential proteins for the neuronal functioning. NF are classified in different families according to functional and structural characteristics, such as the glial cell line-derived neurotrophic factor (GNDF) family and the neurotrophin super-family that includes the brainderived neurotrophic factor (BDNF), the nerve-growth factor (NGF), the neurotrophin-3 (NT-3), and the neurotrophin-4/5 (NT-4/5) 3 . NF may play a role in nociception by regulating peripheral sensitivity of nociceptors and by modulating the central processing of nociceptive information 4 . Considering that peripheral nociceptors and central processing of nociceptive information are both potentially involved in the pathophysiology of TTH, it is reasonable to hypothetize that NF may be involved in TTH pathogenesis.The association between NF and primary headaches has already been investigated. Reduced BDNF and NGF platelet levels have been described in patients with migraine and chronic daily headache (CDH) 5 . BDNF was shown to be increased during migraine and cluster headache attacks 6,7 . Increased cerebrospinal fluid (CSF) levels of NGF and BDNF, ABSTRACTNeurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH). We carried out a cross sectional study including 48 TTH patients and 48 age and gender matched controls. Beck Depression and Anxiety Inventories, and Headache Impact Test were recorded. Serum levels of NF were determined by ELISA. There were not significant differences between NF levels between TTH patients and controls. Patients with chronic and episodic TTH had not significant differences in NF levels. The presence of headache at the time of evaluation did not significantly alter the levels of NF. Depression and anxiety scores as well as headache impact did not correlate with NF levels. Our study suggest that the serum levels of NF are not altered in TTH.Keywords: tension-type headache, neurotrophic factors, depression, anxiety. RESUMOOs fatores neurotróficos (FN) participam da regulação da dor e podem ter um papel na fisiopatologia das cefaleias peimárias. O objetivo do presente estudo foi avaliar os níveis séricos de FN em pacientes com cefaleia do tipo tensional (CTT). Foi realizado cort...

show abstract

Circulating Glial-derived neurotrophic factor is reduced in late-life depression

Cited by 60 publications

References 46 publications

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders

Neurotrophic factors in tension-type headache

Contact Info

Product

Resources

About