Circulating Irisin and Glucose-Dependent Insulinotropic Peptide Are Associated With the Development of Polycystic Ovary Syndrome

Chang, Chia‐Lin; Huang, Shang Yu; Soong, Yung Kuei; Cheng, Po Jen; Wang, Chin‐Jung; Liang, I-Ting

doi:10.1210/jc.2014-1180

Cited by 55 publications

(83 citation statements)

References 65 publications

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“…In concordance with our results, two previously published studies have reported an increase in fasting serum irisin concentrations in PCOS women in comparison to control group [13,14]. The authors concluded that an increase in circulating irisin concentration might contribute to the development of PCOS and may also represent a PCOS biomarker.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska

Karczewska-Kupczewska

Łebkowska

et al. 2016

Endocr J

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Section: Discussionsupporting

confidence: 93%

“…Insulin resistance occurs in approximately 50-70% of women with PCOS [12]. It has been shown that serum irisin concentration is elevated in PCOS women [13,14].…”

Section: Biochemical Analysesmentioning

confidence: 99%

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska

Karczewska-Kupczewska

Łebkowska

et al. 2016

Endocr J

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“…Interestingly, Stengel et al also observed that women with anorexia nervosa and low BMI (12.6±0.7 kg/m2) have lower plasma irisin levels than obese patients [24,49]. A surprisingly high level of irisin was observed in the PCOS patients contrary to what is generally seen in patients with diabetes, although they share insulin resistance state [4,30]. Therefore, there is no clear explanation for the role of metabolic changes.…”

Section: Discussionmentioning

confidence: 99%

“…This has led to the suggestion that either the diabetic state itself or the metabolic condition which resulted in T2DM is accompanied by lower circulating irisin [4]. Chang et al consider that irisin might contribute to the development of PCOS and may also represent a novel PCOS biomarkers [30]. There have also been reports of an association between lower circulating irisin and the risk of non-alcoholic fatty liver disease and heart failure [4].…”

Section: Introductionmentioning

confidence: 99%

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Ali

Al-nuaimi

Al-Musawi³

2016

Int J Pharm Pharm Sci

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Objective: This study was aimed to evaluate the effect of serum leptin level on irisin level in relation to glucose homeostasis that to be associated with hormonal changes (Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Prolactin (PRL), Testosterone (TES)) in obese and nonobese women with polycystic ovary syndrome (PCOS). Methods:Fifty women with polycystic ovaries syndrome (PCOS) and thirty-four apparently healthy control women with regular menstruation (28±2days) were included in this study both of PCOS patients and controls were divided into sub-groups according to their body mass index (BMI) into: twenty-five obese (BMI ≥30) with (BMI= 35.934±0.746) and another twenty-five non-obese polycystic ovaries syndrome women (BMI=25.074±0.456). Whereas, controls were divided as seventeen obese (BMI= 37.140±1.470) and seventeen non-obese (BMI= 25.022±0.683) healthy control women with regular menstruation with an age range (20-40 y) and BMI matching that of the patient groups. Venous blood samples were collected to measure serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH, prolactin (PRL), total testosterone (TES), thyroid stimulating hormone (TSH). As well as, fasting glucose, irisin, leptin, and insulin. Besides, estimating Insulin Resistance (HOMA-IR) index, β-cell function was determined using the Homeostasis Model Assessment of β-cell function (HOMA-β).Results: Serum irisin levels were not significantly different from their corresponding controls, in both obese and non-obese PCOS patients. Whereas, serum irisin levels were elevated significantly in both obese (patients and control) as compared to non-obese (patients and controls), respectively. But, serum leptin levels were significantly elevated in obese PCOS patients as compared to their corresponding control group, nonobese control, and non-obese PCOS patients. However, serum leptin levels were not significantly different in non-obese women groups, both the PCOS and controls. The irisin/insulin ratio expressed no significant variations from its corresponding control in non-obese groups. But the obese PCOS patient's values were highly significantly different as compared to their control (p<0.01). Furthermore, irisin/insulin ratio was elevated significantly in obese control as compared to non-obese patients (p = 0.001), but not with non-obese controls (p=0.114). The leptin/insulin ratio was not significantly varied in PCOS groups from their corresponding control in non-obese (p = 0.094) but in obese PCOS patients, there was significantly different as compared to its control (p = 0.01). Furthermore, leptin to insulin ratio was not significantly different between patients groups (non-obese and obese, p=0.133), nor between the studied controls (p=0.705). Conclusion:Although serum irisin levels show no significant variation in subjects in relation to PCOS condition, it seems more to be related to BMI, since it's secreted by adipocytes. And because leptin and irisin levels would be elevated in obese subjects th...

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“…This may be due to the absence of metabolic dysfunction in the PA group or a difference may have been masked by the low concentration of vitamin D in the C group. Scientific studies have shown that patients with a metabolic profile similar to that of children with PA had higher levels of irisin when compared to controls without Mets (Park et al 2013) and PCOS (Chang et al 2014). These data suggested that irisin could function as a protective agent against an excessive influx of energy as it increases energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

Plasma levels of irisin in children with idiopathic premature adrenarche

Furino¹,

Furino²,

Avó³

et al. 2016

IJANS

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Background: Premature adrenarche (PA) is characterized by presence of isolated pubic and/or axillary hair, acne and body odor before age 8(9) in girls (boys). These individuals are at increased risk of developing insulin resistance, metabolic syndrome and polycistic ovarian syndrome. Irisin seems to have an active role in the metabolism of carbohydrates and lipids, however little is known about this hormone in PA. Objective: To analyze irisin levels in children diagnosed with PA and its relationship with their body composition. Methodology: Exploratory cross-sectional study that evaluated 15 children with PA and 15 matched controls (C). Anthropometric data were measured: height, weight, waist circumference (WC) and triceps skinfold. Fasting blood glucose(G), insulin(I), 17OHP, total cholesterol, LDL, HDL, triglycerides, DHEA-S, 25(OH)D and irisin levels were determined. Results: The levels (mean±SEM) of triglycerides [99±14, 8mg/dl (C); 68±9, 1mg/dl (AP)] and 25(OH) D [26±0, 9ng/ml(C); 30.2±1.6ng/ml (AP)] were significantly different between the groups. WC above p90 and G/ I<7 were found in 6.7% of the C group versus 33.3% and 20% of the PA group, respectively. Conclusions: PA children presented a lower G/I and a higher waist WC compared to the C group, suggesting an increased risk of metabolic disease. Irisin levels were not different between the groups. The significantly higher levels of TGs from the C group may be related to their reduced levels of 25(OH) D, which may also have masked differences in irisin levels. This study suggests that determination of vitamin D levels may be necessary to evaluate metabolic data, based on the significant frequency of this hormone insufficiency/deficiency in the pediatric population.

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Circulating Irisin and Glucose-Dependent Insulinotropic Peptide Are Associated With the Development of Polycystic Ovary Syndrome

Abstract: Although there is as yet no evidence for a causal link between irisin and/or GIP and PCOS, it is conceivable that irisin and GIP might contribute to the development of PCOS and may also represent novel PCOS biomarkers.

Cited by 55 publications

References 65 publications

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Plasma levels of irisin in children with idiopathic premature adrenarche

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