Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Ali, Shatha H.; Al-nuaimi, Ali M. A.; Al-Musawi, Bushra J.

doi:10.22159/ijpps.2016v8i10.14160

Cited by 7 publications

(16 citation statements)

References 52 publications

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“…In contrast to adiponectin, leptin levels increase in obesity which is proportional to the degree of adiposity [13,31]. In this study, serum leptin and LAR were higher in both obese T2DM and obese nondiabetic patients with respect to healthy control.…”

Section: Discussionmentioning

confidence: 44%

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Singh

Mahajan

Kaur

2019

Asian J Pharm Clin Res

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Objective: This study was done to explore the correlation if any, between obesity markers adiponectin, leptin, and protein oxidative stress (OS) status in obese with and without type 2 diabetic mellitus (T2DM) patients. Methods: In the present study, 30 healthy subjects, 30 obese non-diabetics, and 30 obese T2DM patients were enrolled. Protein OS parameters such as advanced oxidation of protein products (AOPPs) and protein carbonyl (PC) were estimated. Serum leptin, adiponectin, and insulin levels were measured by ELISA. Results: The AOPP, PC, leptin, leptin adiponectin ratio (LAR), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were significantly higher in obese non-diabetic and obese T2DM as compared to healthy control (p<0.001). However, serum adiponectin levels were significantly lower in obese non-diabetic and obese T2DM as compared to control (p<0.001). HOMA-IR and LAR both the index of IR were increased in obese non-diabetic and obese T2DM. Positive correlations were observed for AOPP with body mass index, PC in obese non-diabetic and with fasting blood glucose, postprandial blood glucose, HOMA-IR, and PC in obese T2DM. A negative correlation was found between PC and adiponectin in obese non-diabetic and obese T2DM. A significant inverse correlation was obtained between leptin and adiponectin in obese T2DM only. Conclusion: The present study suggested that increased protein OS, hyperinsulinemia, and hyperleptinemia may lead to hypoadiponectinemia in obese with and without T2DM. Moreover, determination of protein oxidation markers can be useful for monitoring the dysregulation of adipokines and glucose metabolism in obesity and T2DM.

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Section: Discussionmentioning

confidence: 44%

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Singh

Mahajan

Kaur

2019

Asian J Pharm Clin Res

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“…MetS is a multifactorial clinical condition where each of its factors plays a crucial role in the development of clinical disorders such as diabetes and CVD [14]. In addition to diabetes and CVD, numerous clinical studies have also found the association of MetS with other disorders such as sleep-disordered breathing, polycystic ovary syndrome, and some cancer types [15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome in Urban and Rural Population of Greater Noida National Capital Region of India

Sharma

Pandey

Nagtilak

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the prevalence of metabolic syndrome (MetS) and to define its predictors in urban and rural patients presenting to tertiary care hospitals located in Greater Noida district Gautam Budh Nagar, India.Methods: A total of 367 participants recruited in the study, aged 20–55 years, comprising, 290 patients (149 rural and 141 urban) and 77 healthy age, sex-matched controls from the study area. Anthropometric, clinical and laboratory examination information was obtained. MetS was defined as per the National Cholesterol Education Program, Adult Treatment Panel III (NCEP, ATP III) report.Results: There were significant differences in biochemical and anthropometric measurements between control and patient population (p<0.05). There was a substantial difference in the prevalence of MetS among male and female patient population of urban as well as rural areas. As per NCEP, ATP III criteria, the prevalence of MetS in urban patient population was 21.7% in male and 27.8% in female whereas rural male and female exhibited 13.8% and 18.8% of MetS, respectively. Waist circumference was found as the strongest predictor of MetS among the patient population.Conclusion: Rapid urbanization of the cities is affecting the village life and indicating toward a major burden of diseases associated with MetS. A higher prevalence of MetS in female irrespective of the area of residence needs major health-care policy change. There is an urgent need to address this issue by adopting healthy eating, physical exercise, and weight reduction.

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“…Also, Ali et al [37] reported that serum irisin levels were not significantly differed from their corresponding controls, in both Another study has been found that circulating irisin was significantly lower in PCOS patients [38] .…”

Section: Histopathological Findingsmentioning

confidence: 92%

The RELATION OF SERUM IRISIN LEVEL WITH METABOLIC AND HORMONAL CHANGES IN RAT MODEL OF POLYCYSTIC OVARY

Ibrahim¹,

Ahmed²,

Moety³

et al. 2018

Zagazig University Medical Journal

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Background: Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility in female. It is usually associated with insulin resistance (IR), obesity, hyperlipidemia, and type II diabetes. Irisin is amyokine which increases energy expenditure and protects against insulin resistance and obesity. There were controversial studies about the levels of irisin and its relation to hormonal and metabolic changes in PCOS. This study was designed to estimate serum level of irisin in letrozole-induced PCOS in both lean and obese female rats, and to study the link between serum irisin level and some metabolic and hormonal parameters in PCOS. Material and Methods: This study was conducted on 48 young virgin female of local strain albino rats. They were randomly divided into 2 equal groups: Group I: lean group were fed on normal laboratory chow diet and Group II: A high fat diet induced obesity group and each group was subdivided into group A (control) and group B (letrozole induced PCOS). Fasting serum irisin, Lutenizig hormone (LH), Folliclular stimulating hormone (FSH), testosterone, estradiol, progesterone, insulin, glucose, triglycerides, cholesterol, LDL and HDL levels were estimated. In addition, body mass index (BMI) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were calculated in all groups at the end of the experiment. Results: Serum irisin level was elevated in both lean and obese PCOS groups when compared to both lean and obese control groups. In addition, obese PCOS group had significant higher level of irisin when compared to lean PCOS group. Conclusion: Serum irisin level was positively correlated with BMI, HDL and testosterone levels and negatively correlated with HOMA-IR, insulin, cholesterol, triglycerides and LDL levels. Irisin may have a role in the development of polycystic ovary syndrome.

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Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

Cited by 7 publications

References 52 publications

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Metabolic Syndrome in Urban and Rural Population of Greater Noida National Capital Region of India

The RELATION OF SERUM IRISIN LEVEL WITH METABOLIC AND HORMONAL CHANGES IN RAT MODEL OF POLYCYSTIC OVARY

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