Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska, Agnieszka; Karczewska-Kupczewska, Monika; Łebkowska, Agnieszka; Milewski, Robert; Górska, Maria; Otziomek, Elżbieta; Nikołajuk, Agnieszka; Wołczyński, S; Kowalska, Irina

doi:10.1507/endocrj.ej16-0249

Cited by 28 publications

(37 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At baseline values irisin seems to increase or not different in insulin resistance models such as polycystic ovary syndrome (PCOS) as reported by recent papers [30, 31]. …”

Section: Discussionmentioning

confidence: 72%

Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People

Benedini

Dozio

Invernizzi

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

We compared irisin levels among groups of differently trained healthy individuals to explore the role of irisin as a physiological linker between exercise and metabolic health. Irisin and biochemical parameters of glucose and lipid metabolism were assessed in 70 healthy volunteers stratified for sport performance level into four groups: (1) 20 elite athletes of national level, (2) 20 subelite athletes of local level, (3) 20 recreational athletes, and (4) 10 sedentary subjects. All biochemical parameters were within the ranges of normality. Fasting glucose, HOMA-IR, and total cholesterol levels were inversely related to the degree of physical activity. HbA1c was higher in elite athletes compared to all the other groups (p < 0.01). A U-shaped relation between free fatty acids and the degree of physical activity was observed. All groups showed similar plasma irisin levels. After correction for the degree of insulin resistance (irisin/HOMA-IR), elite athletes showed higher levels compared to sedentary and recreational subjects (p < 0.01 and p < 0.05, resp.). In addition, the number of metabolic parameters correlated with irisin increased at increasing the training status. Our study suggests a correlation between sport performance, insulin sensitivity, and irisin levels. Irisin may be one potential mediator of the beneficial effects of exercise on metabolic profile.

show abstract

“…At baseline values irisin seems to increase or not different in insulin resistance models such as polycystic ovary syndrome (PCOS) as reported by recent papers [30, 31]. …”

Section: Discussionmentioning

confidence: 72%

Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People

Benedini

Dozio

Invernizzi

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that circulating ZAG, Irisin and Betatrophin concentrations were significantly reduced or elevated in patients with T2DM or PCOS, respectively, and were associated with IR [10][11][12][20][21][22]. In addition, a recent meta-analysis and other populations had indicated that serum irisin concentration in PCOS women were higher than that in healthy women, this elevaluation could be partly attributed to the BMI in PCOS patients [23][24][25][26]. Therefore, most studies have revealed that circulating Irisin levels indeed has a tendency to increase in PCOS women.…”

Section: Discussionmentioning

confidence: 98%

“…In PCOS patients, circulating ZAG levels were reported to be consistently reduced [10,27,28]. However, the relationship between circulating betatrophin levels and PCOS is controversial and the studies in the literature are inconsistent [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Growing evidence indicates that these cytokines have some roles in the pathogenesis of T2DM and PCOS, and are also involved in IR development.…”

Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

Aims Irisin, Betatrophin and Zinc-α2-glycoprotein (ZAG) have been shown to be associated with insulin resistance (IR) and polycystic ovary syndrome (PCOS), respectively. The purpose of this study is to explore the potential accuracy of this combination of three cytokines in screening PCOS. Methods 186 individuals were recruited for this study. Circulating Irisin, Betatrophin and ZAG concentrations were measured by enzyme-linked immunosorbent assay. The association between these serum biomarkers and PCOS was assessed by logistic regression analysis. Receiver operating curve (ROC) analysis was performed to evaluate the diagnostic value of these biomarkers for PCOS women. Results In women with PCOS, serum Irisin and Betatrophin levels were markedly elevated compared to those in healthy controls (p<0.01), while ZAG levels were lower (p<0.01). PCOS women with IR (M-value<6.28) had lower circulating ZAG concentrations, and higher circulating Irisin and Betatrophin levels relative to PCOS women without IR (M-value ≥ 6.28). ROC curve analyses showed that the AUC for Irisin, ZAG and Betatrophin for predicting PCOS were 0.77, 0.83 and 0.85, respectively. In a joint ROC curves analysis of these serum markers and other parameters, the results showed that the AUC was 0.93, and the sensitivity and specificity were 82.1 % and 92.3 %, respectively. Conclusions When compared to using single cytokine, the analysis of Irisin, ZAG and Betatrophin elevates the accuracy in diagnosing PCOS.

show abstract

“…Current knowledge about the function of the hormone irisin in biological systems is limited . Few studies have examined serum irisin levels in adult women with PCOS; however, data comparing serum irisin concentrations in adult PCOS women with control women have been inconsistent. Four studies demonstrated significantly elevated irisin levels in patients with PCOS compared to those of control women, whereas others showed significantly lower mean serum irisin concentrations in women with PCOS than control subjects or nonsignificant differences .…”

Section: Introductionmentioning

confidence: 99%

“…6 Few studies 5,[7][8][9][10][11][12][13] have examined serum irisin levels in adult women with PCOS; however, data comparing serum irisin concentrations in adult PCOS women with control women have been inconsistent. Four studies demonstrated significantly elevated irisin levels in patients with PCOS compared to those of control women, 5,7,9,13 whereas others showed significantly lower mean serum irisin concentrations in women with PCOS than control subjects 8 or nonsignificant differences. 10 Body mass index (BMI) may be a confounding factor in these studies, as irisin, a general indicator of body fat mass, 6 has been found to be positively correlated with BMI in adult women with or without PCOS and across a wide range of BMI.…”

Section: Introductionmentioning

confidence: 99%