Circulating biomarkers of oxidative stress in normal pregnancy and preeclampsia and efficacy of antioxidant supplementation

Khatri, Meena

doi:10.5455/2320-1770.ijrcog20130909

Cited by 9 publications

(10 citation statements)

References 9 publications

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“…In normal pregnancy, increasing urinary protein excretion is detected due to a mixture of amplified permeability of the glomerular basement membrane and increased glomerular filtration rate. Also, in PIH highly molecular weight protein was lost due to endothelial dysfunction and vasospasm [17]. Serum albumin was slightly elevated in PIH than normal pregnant and this is in accordance with the finding of previous study done by Ephraim, et al, 2018 who recorded a high urinary protein level and decreased serum albumin concentration among preeclamptic women compared to the healthy pregnant women.…”

Section: Resultssupporting

confidence: 91%

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Bayram

Salih

Eleiwe

2018

ijs

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Pregnancy-induced hypertension (PIH) is a major pregnancy complication that causes pregnant women mortality. Here, we had scrutinized the correlation between serum levels of -hCG and biochemical parameters in PIH. Serum samples were collected from eighty Iraqi women (forty women with pregnancy-induced hypertension as patients group, twenty normotensive pregnant women as a positive control, and twenty normotensive non-pregnant women as a negative control) all groups were diagnosed clinically. All -hCG hormone level was measured for all studied groups, also serum uric acid, albumin, and total protein levels were measured as biochemical parameters. Data analysis showed that serum level of -hCG hormone was significant increase (p≤0.05) in PIH in compared to control groups. Also Uric acid level was increased significantly in PIH group in compared with control groups. While Albumin show there was no significant difference in PIH group. Total serum protein level was measured by Bradford total Protein assay all results was in normal value and showed a significant difference in PIH group in comparison to control groups. Our study shows that there is correlation between β-hCG with uric acid and albumin levels in PIH. Serial estimation of serum β-hCG, uric acid, and albumin can be important to use as a marker of disease and also can be used in better early management of established cases that lead to preeclampsia and eclampsia.

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Section: Resultssupporting

confidence: 91%

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Bayram

Salih

Eleiwe

2018

ijs

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“…Many researchers have demonstrated increased levels of lipid peroxidation metabolites such as MDA and lipid peroxides in pregnancy, and even significantly higher levels in women with PE [26]. These products may suppress prostacyclin synthesis and stimulate smooth muscle contraction resulting in widespread vasospasm, a dominant feature of PE.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Gargari

Tabrizi²,

Sadien³

et al. 2015

Gynecol Obstet Invest

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Background/Aims: Pre-eclampsia (PE) is associated with unfavorable metabolic profiles. Oxidative stress and inflammation have been increasingly postulated as major contributors to PE. Research suggests that vitamin D status is disturbed in women with PE. The aims of this study were to compare the serum levels of vitamin D and oxidative stress status in women with PE vs. women with normal pregnancies, and to evaluate the relationship between these 2 factors in women with PE. Methods: In this case-control study, 40 women with PE and 40 healthy pregnant women were selected, and high-sensitivity C-reactive protein, malondialdehyde (MDA), total antioxidant capacity (TAC) and 25-hydroxyvitamin D (25(OH)D) levels were assessed. We compared the biochemical indicators between the 2 groups by analysing the data using the independent t test, Mann-Whitney U test, chi-square and logistic regression. Results: Compared with the controls, the serum levels of MDA in women with PE were significantly higher (p = 0.001) and TAC and 25(OH)D levels were significantly lower (p < 0.05). TAC concentration was positively associated with 25(OH)D levels in cases of PE (β = 0.428, p = 0.01). Conclusion: Our findings show lower levels of TAC and 25(OH)D in women with PE in comparison to controls, while having similar vitamin D intakes. In addition, our results suggest a positive relationship between TAC concentration and 25(OH)D levels in PE cases.

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“…These results show that oxidative stress as coupled by alterations in the levels of MDA may be contributing factor in the pathogenesis of pregnancy induced hypertension. A significant increase in this circulating indicator of oxidative stress in pre-eclamptic mothers has been reported by Khatri et al 23 Increase in oxidative stress markers in turn have been found to damage the maternal vascular endothelium leading to the elevation in diastolic pressure which further worsened the state of hypertensive mothers. 24 A delicate balance of anti-oxidant enzymes is necessary for reducing oxidative stresses.…”

Section: Discussionmentioning

confidence: 76%

Pregnancy induced hypertension: lipid peroxidation and antioxidant status

Shah¹,

Rashid²,

Khan³

et al. 2019

Int J Res Med Sci

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Background: Pregnancy is a stressful condition accompanied by a high energy demand and increased oxygen requirement. Oxidative stress has been recognized as a significant factor linked to hypertension. Elucidation of anti-oxidant cascade in patients with pregnancy induced hypertension (PIH). can give insights about the oxidative stress and lead to better management of the condition. It was a prospective case control study to elucidate the parameters of oxidative stress in patients with PIH.Methods: Levels of Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were eludidated using enzyme linked immunosorbent assay (ELISA) in hypertensive mothers and their age matched pregnant and non-pregnant controls to determine the lipid peroxidation and oxidative stress.Results: A total of four hundred and twenty study subjects were enrolled in the study. Malondialdehyde levels from mothers with hypertension were significantly higher than their age matched pregnant controls. The results indicate that oxidative stress induced by pregnancy induced hypertension manifests as increased lipid peroxidation. Conclusion: There is a decrement in anti-oxidant status reflecting the ineffective scavenging of reactive oxygen species resulting in oxidative damage and tissue injury.

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Circulating biomarkers of oxidative stress in normal pregnancy and preeclampsia and efficacy of antioxidant supplementation

Cited by 9 publications

References 9 publications

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia

Pregnancy induced hypertension: lipid peroxidation and antioxidant status

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