Circulating Biomarkers for Cholangiocarcinoma

Loosen, Sven H.; Vucur, Mihael; Roderburg, Christoph; Luedde, Tom

doi:10.1159/000488342

Cited by 18 publications

(13 citation statements)

References 68 publications

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“…7 Nevertheless, the clinically available tumor markers CEA and CA19-9 are mostly used to monitor tumor response to chemotherapy, and the existing preoperative stratification tools often fail to identify the ideal candidates for a surgical treatment approach. 33,34 Herein, we showed that serum levels of suPAR are elevated in 2 independent cohorts of patients with BTC who underwent surgical tumor resection compared to patients with PSC and healthy controls. Moreover, our data provided evidence that suPAR serum levels before and after surgery might yield valuable information on the patients' postoperative outcome.…”

Section: Discussionmentioning

confidence: 90%

Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer

et al. 2020

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suPAR pre-OP Log-rank = 8.003 p = 0.005 2,500 Overall survival Circulating suPAR Biliary Tract Cancer (BTC) Highlights Biliary tract cancer is associated with poor outcomes and increasing incidence. Surgical resection is the only potentially curative treatment option for patients with biliary tract cancer. The identification of ideal surgical candidates has remained challenging. Circulating suPAR represents a novel diagnostic and prognostic biomarker in resectable patients. SuPAR might be useful to identify patients with biliary tract cancer who will benefit most from tumor resection.

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Section: Discussionmentioning

confidence: 90%

Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer

et al. 2020

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“…Cholangiocarcinoma (CCA) is the second most common primary liver tumor after HCC 89 . CCA and HCC display heterogeneity at both morphologic and molecular levels 90 .…”

Section: Hh Signaling In Liver Cancersmentioning

confidence: 99%

Role of canonical Hedgehog signaling pathway in liver

Gao¹,

Zhang²,

Zhang³

et al. 2018

Int. J. Biol. Sci.

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Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.

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“…Cholangiocarcinoma (CCA), also known as bile duct cancer, is the second most common malignancy of the liver, accounting for 10%‐20% of primary hepatic malignancies . CCA is classified as intrahepatic, perihilar, or distal based on anatomic location .…”

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confidence: 99%

Characterization of Gut Microbiota, Bile Acid Metabolism, and Cytokines in Intrahepatic Cholangiocarcinoma

et al. 2019

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Intrahepatic cholangiocarcinoma (ICC), a type of bile duct cancer, has a high mortality rate. Gut microbiota, bile acid (BA) metabolism, and cytokines have not been characterized in patients with ICC, and better noninvasive diagnostic approaches for ICC are essential to be established. Therefore, in this study we aimed to improve our understanding of changes in gut microbiota, BA metabolism, and cytokines in patients with ICC. We found that the α‐diversities and β‐diversities of ICC were highest and that the abundances of four genera (Lactobacillus, Actinomyces, Peptostreptococcaceae, and Alloscardovia) were increased in patients with ICC compared with those in patients with hepatocellular carcinoma or liver cirrhosis and in healthy individuals. The glycoursodeoxycholic acid and tauroursodeoxycholic acid (TUDCA) plasma‐stool ratios were obviously increased in patients with ICC. Furthermore, the genera Lactobacillus and Alloscardovia that were positively correlated with TUDCA plasma‐stool ratios were combined to discriminate ICC from the other three diseases. Vascular invasion (VI) frequently led to a poor prognosis in patients with ICC. Compared with patients with ICC without VI, patients with VI had a greater abundance of the family Ruminococcaceae, increased levels of plasma interleukin (IL)‐4 and six conjugated BAs, and decreased levels of plasma IL‐6 and chenodeoxycholic acid. A positive correlation between plasma taurocholic acid and IL‐4 was observed in patients with ICC. Plasma TUDCA was negatively correlated with the abundance of the genus Pseudoramibacter and the survival time of patients with ICC, but had no effect on tumor size, as determined in two murine tumor models. Conclusion: In this study, we identified some biomarkers, including gut microbiota, BAs and inflammatory cytokines, for the diagnosis of ICC and prediction of VI in patients with ICC.

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Circulating Biomarkers for Cholangiocarcinoma

Cited by 18 publications

References 68 publications

Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer

Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer

Role of canonical Hedgehog signaling pathway in liver

Characterization of Gut Microbiota, Bile Acid Metabolism, and Cytokines in Intrahepatic Cholangiocarcinoma

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