Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3

Li, Zhiyang; Zheng, Jiehua; Lin, Weixun; Weng, Jiaquan; Hong, Weida; Zou, Juan; Zhang, Taofeng; Ye, Changsheng; Chen, Yexi

doi:10.1080/15384101.2020.1824717

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…It is currently theorized that circRNAs are mainly distributed in the cytoplasm and play a role in regulating tumor progression through the adsorption of miRNAs. For example, circ_0001785 can sponge miR-942 or miR-1200 to regulate breast cancer or osteosarcoma progression, respectively ( 31 , 32 ); and circ_0000285 can absorb miR-409-3p, miR-197-3p and miR-599, thereby affecting the progression of cervical cancer and osteosarcoma ( 24 , 33 , 34 ). Analysis using an online database revealed 29 miRNAs that may serve as the target of circ_0001367.…”

Section: Discussionmentioning

confidence: 99%

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

et al. 2021

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Glioma is the most common primary intracranial malignant tumour in adults. It has a high incidence and poses a serious threat to human health. Circular RNA is a hotspot of cancer research. In this study, we aimed to explore the role of circ_0001367 in gliomagenesis and the underlying mechanism. First, qRT-PCR was conducted, which showed that circ_0001367 level was downregulated in glioma tissues and cells. Next, gain-of-function and loss-of-function assays were performed, which indicated that circ_0001367 inhibited the proliferation, migration and invasion of glioma cells. Subsequent bioinformatics analysis, dual-luciferase reporter assays, RNA immunoprecipitation assays and cell function assays demonstrated that circ_0001367 inhibited the proliferation, migration and invasion of glioma cells by absorbing miR-545-3p and thereby regulating the expression of leucine zipper protein (LUZP1). Finally, an in vivo experiment was conducted, which demonstrated that circ_0001367 inhibited glioma growth in vivo by modulating miR-545-3p and LUZP1. Taken together, the results of this study demonstrate that the circ_0001367/miR-545-3p/LUZP1 axis may be a novel target for glioma therapy.

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Section: Discussionmentioning

confidence: 99%

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

et al. 2021

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“…To determine the mechanism of action of hsa_circ_0091581 on glioma proliferation, migration, and invasion, we used the results described in the literature that suggested that circRNAs can play a regulatory role by adsorbing miRNAs [30][31][32]. Hsa_circ_0001785 sponges miR-942 to regulate breast cancer progression [33]; hsa_circ_0005556 sponges miR-4270 to facilitate gastric cancer progression [34]; and hsa_circ_0004913 act as a sponge for miR-184 and is thus involved in the progress of hepatocellular carcinoma [35]. Ji and Wei et al reported that hsa_circ_0091581 is involved in hepatocellular carcinoma progression by sponging miR-591 and miR-526b [28,29].…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

Qian

et al. 2021

J. Cancer

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Glioma is a pervasive malignancy and the main cause of cancer-related deaths worldwide. Circular RNA is an important subject of cancer research, and its role and function in glioma are poorly understood. This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. The results of the rescue experiments indicated that hsa_circ_0091581 regulates proliferation, migration, and invasion of glioma cells by targeting RMI1 in a miR-1243-5p dependent manner. The results of the nude mice xenograft assays showed that knockdown of hsa_circ_0091581 inhibits glioma growth in vivo. Thus, our study determined the role of hsa_circ_0091581/miR-1243-5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma.

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“…To further identify the downstream target of circSHPRH/miR-942, we first screened 9 tumor suppressors (DLG2, SOCS3, ALX4, GFI1, BARX2, ZNF471, NFKBIA, FOXA2, RRM2B) that were confirmed to be the direct targets of miR-942 in published papers [15,[17][18][19][20][21][22][23][24]. Then, we investigated whether circSHPRH silencing could influence these genes at the mRNA level.…”

Section: Mir-942 Directly Targets Barx2mentioning

confidence: 99%

Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway

Zuo

Zhu

Han

et al. 2022

Aging

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Bladder cancer (BCa) is one of the most common tumors of the genitourinary system. However, the detailed molecular mechanism of BCa progression is still unclear. Recently, an increasing number of studies have demonstrated that circular RNAs (circRNAs) play a critical role in the tumorigenesis and progression of BCa. In this article, we showed that circSHPRH expression was obviously decreased in BCa tissues, compared with adjacent normal tissues. Moreover, a low circSHPRH level was positively correlated with a high grade, a high pathological stage, lymphatic metastasis and an unfavorable prognosis for BCa patients. Cell function studies indicated that silencing circSHPRH dramatically increased the proliferation, migration and invasion of BCa cells. Animal experiments revealed that circSHPRH overexpression repressed tumor growth. Mechanistic studies demonstrated that circSHPRH could combine with miR-942 and serve as a sponge of miR-942, which targets BARX2 in BCa cells. Rescue experiments showed that suppression of miR-942 or BARX2 overexpression could significantly abrogate the promoting effects of circSHPRH silencing on BCa cell proliferation and invasion. Furthermore, circSHPRH overexpression partly eliminated the suppressive effects of miR-942 on BARX2 expression. In addition, circSHPRH knockdown promoted activation of the Wnt/β-catenin signaling pathway by regulating BARX2. Taken together, our findings indicate that circSHPRH serves as a sponge of miR-942 to inhibit BCa progression by upregulating BARX2 expression, thereby inhibiting the Wnt/β-catenin signaling pathway.

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Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3

Cited by 25 publications

References 25 publications

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway

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