2018
DOI: 10.18632/aging.101437
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Abstract: Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression and function of circRNAs in the tree shrew brain. In this study, we used RNA-seq to identify 35,007 circRNAs in hippocampus and cerebellum samples from infant (aged 47–52 days), young (aged 15–18 months), and old (aged 78–86 months) tree shrews. We observed no significant changes in the total circRNA expression profiles in different brain regions over time… Show more

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Cited by 30 publications
(31 citation statements)
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“…From a wide range of organisms, including C. elegans [ 13 ], Drosophila [ 12 ], mice [ 10 ], rats [ 28 ], monkeys [ 11 ], tree shrews [ 29 ], and pigs [ 30 ], a large number of circRNAs significantly changed during aging were identified. For example, the accumulation of circRNAs in the brain was discovered across different species compared to their linear isoforms [ 10 , 13 , 23 , 29 ]. This may account for the abundant enrichment of post-mitotic cells in neural tissues and the high stability of circRNAs in cells [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…From a wide range of organisms, including C. elegans [ 13 ], Drosophila [ 12 ], mice [ 10 ], rats [ 28 ], monkeys [ 11 ], tree shrews [ 29 ], and pigs [ 30 ], a large number of circRNAs significantly changed during aging were identified. For example, the accumulation of circRNAs in the brain was discovered across different species compared to their linear isoforms [ 10 , 13 , 23 , 29 ]. This may account for the abundant enrichment of post-mitotic cells in neural tissues and the high stability of circRNAs in cells [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…The tree shrew (Tupaia belangeri) is a new laboratory animal belonging to the family Tupaiidae, order Scandentia, widely distributed in South Asia, Southeast Asia and Southwest China [8]. This small mammal is similar in appearance to the squirrel and feeds on insects, fruits and small vertebrates.…”
Section: Introductionmentioning
confidence: 99%
“…Until recently, circRNAs were believed to be transcription byproducts because their functions were unclear. However, deep sequencing has led to identification of many new circRNAs in various species such as Caenorhabditiselegans , zebrafish, Arabidopsis thaliana , Plasmodium falciparum , pigs, and tree shrews (Memczak et al ; Wang et al ; Veno et al ; Lu et al ) (Fig. ).…”
mentioning
confidence: 99%