2018
DOI: 10.18632/aging.101565
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Abstract: Circular RNAs (circRNAs) have recently been shown to exert effects on multiple pathological processes by acting as miRNA sponges. However, the roles of circRNAs in ovarian senescence are largely unknown. The objective of this study was to identify the circRNAs involved in ovarian aging and predict their potential biological functions. We first performed RNA-sequencing to generate ovarian circRNA expression profiles from young (n = 3) and aging (n = 3) groups. In total, 48,220 circRNAs were identified, of which… Show more

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Cited by 32 publications
(26 citation statements)
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References 46 publications
(59 reference statements)
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“…Albeit with the same experimental approach used in Chioccarelli et al (20), our purpose was to identify the circRNA payload in SPZ collected from infertile men, adding a new piece of knowledge to what has already been discussed for normozoospermic subjects (20). As in human testis, in ovary and normozoospermic derived SPZ (17,18,20), exonic circRNAs were the highest number and were widely scattered across all chromosomes, sexual and mitochondrial chromosomes included. In order to identify a differential cargo of circRNAs in correlation to sperm quality, we separated SPZ that have a good morphology and motility (A SPZ) from SPZ that is not suitable for fertilization (B SPZ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Albeit with the same experimental approach used in Chioccarelli et al (20), our purpose was to identify the circRNA payload in SPZ collected from infertile men, adding a new piece of knowledge to what has already been discussed for normozoospermic subjects (20). As in human testis, in ovary and normozoospermic derived SPZ (17,18,20), exonic circRNAs were the highest number and were widely scattered across all chromosomes, sexual and mitochondrial chromosomes included. In order to identify a differential cargo of circRNAs in correlation to sperm quality, we separated SPZ that have a good morphology and motility (A SPZ) from SPZ that is not suitable for fertilization (B SPZ).…”
Section: Discussionmentioning
confidence: 99%
“…The role of circRNA has been deeply investigated in both pathological and physiological conditions (8,16). With regard to reproductive organs, circRNAs has been identified in both testis and ovary (17,18) and their distribution has been correlated to germ cell progression (19). Human SPZ also retain circRNAs; interestingly, these molecules are differentially expressed in populations of SPZ with good and poor quality and show a peculiar subcellular localization in SPZ head and tail-enriched preparations to indicate that they are preserved during SPZ maturation and transferred into oocyte during fertilization (20,21).…”
Section: Introductionmentioning
confidence: 99%
“…What emerges from these studies is surely the maternal contribution in circRNA embryonic inheritance and that circRNAs are actively produced in both oocytes and ovary [263,264]. A genome-wide identification of human ovary circRNAs has been carried out showing circRNA dynamical regulation during ovarian aging, as already suggested for brain [90,263]. In the ovary, circRNAs have been associated with metabolic processes, serine/threonine metabolism and especially steroid hormone biosynthesis, a critical signaling for normal ovarian functionality.…”
Section: Circrnas: From Testis To Embryomentioning
confidence: 90%
“…Moreover, testis-derived circRNAs have been detected in human seminal plasma because they are resistant to exonuclease activity due to their circular form which confer them a great potential as liquid biopsy tools for various human diseases (Dong et al, 2016;Cai et al, 2018). Interestingly, in a recent study the expression of eight candidate circRNAs generated from six linear transcripts (CNR1, LEPR, MTHFR, NAPEPLD, NPC2, and SIRT1) has been profiled in five RNA samples from human and murine spermatozoa.…”
Section: Circrnas In Reproductive System and Germ Cell Developmentmentioning
confidence: 99%