Current status and potential role of circular RNAs in neurological disorders

Lu, Shanshan; Yang, Xue; Wang, Chudong; Chen, Siqi; Lu, Shuang; Yan, Weitao; Xiong, Kun; Liu, Fengxia; Yan, Jie

doi:10.1111/jnc.14724

Cited by 45 publications

(35 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results also support previous findings that circRNAs can serve as novel diagnostic biomarkers and promising therapeutic targets for IS 26,[36][37][38][39] . In the present study, based on the results of bioinformatic analyses, three of the top ten significantly DE circRNAs were selected for PCR validation in AIS patients and healthy controls.…”

Section: Discussionsupporting

confidence: 91%

Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population

Chen

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Recent studies have found that circular RNAs (circRNAs) play crucial roles not only in the normal growth and the development of different tissues and organs but also in the pathogenesis and progression of various disorders. However, the expression patterns and the function of circRNAs in acute ischemic stroke (AIS) in the South Chinese Han population are unclear. In the present study, RNA sequencing (RNA-seq) data was generated from 3 AIS patients and 3 healthy controls. The circRNAs were detected and identified by CIRI2 and Find_circ software. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses were used to detect the expression of circRNAs. Meanwhile, the potential diagnostic value of the selected circRNAs for AIS was assessed by generating receiver operating characteristic (ROC) curve with area under curve (AUC). The bioinformatic analysis of the host genes of differentially expressed (DE) circRNAs was performed by gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, KOBAS for pathway analysis and regulatory network analysis. miRNA-circRNA and miRNA-mRNA interactions were predicted by using TargetScan, miRanda and starBase. CircRNA-miRNA-mRNA interaction networks were created with Cytoscape. Our result showed that there were 2270 DE circRNAs between AIS patients and healthy controls. Among them, 659 were found upregulated and 1611 were downregulated. Bioinformatic analysis showed that the DE circRNAs were related to the following biological processes: endocytosis, energy metabolism, apoptosis, FoxO signaling pathway, platelet activation, neurotrophin signaling pathway and VEGF signaling pathway, which may be associated with the pathological of AIS. Three randomly selected circRNAs were successfully validated by qRT-PCR. The results show that hsa_circ_0005548 was significantly upregulated, while hsa_circ_0000607 and hsa_circ_0002465 were significantly downregulated in AIS. Furthermore, the AUC values for hsa_circ_005548, hsa_circ_0000607 and hsa_circ_0002465 were 0.51, 0.75 and 0.69, respectively, suggesting that hsa_circ_0000607 and hsa_circ_0002465 could be potential biomarkers for AIS. In addition, Bcl2 was predicted to be a direct target of miR-337-3p, and hsa_circRNA_0000607 was predicted to act as a sponge for miR-337-3p. Thus, hsa_circ_0000607 may be involved in AIS by regulating the miR-337-3p/ Bcl2 axis. Collectively, our findings indicate that numerous dysregulated circRNAs may play pivotal functional roles in AIS and hsa_circ_0000607 may play a crucial role in the pathogenesis and progression of AIS by regulating the miR-337-3p/Bcl2 axis. Stroke is one of the leading causes of death and a major cause of long-term disability worldwide. Approximately 87% of all stroke cases are ischemic stroke (IS) 1. Although major progress in the diagnosis and treatment of acute ischemic stroke (AIS) has been reported in recent years, the mortality and long-term disability rates of IS are still high. Moreover, recombinant tissue plasminogen activa...

show abstract

Section: Discussionsupporting

confidence: 91%

Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population

Chen

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Similar to a previous report, 11 our data revealed that the onset of symptoms occurred mostly within 5‐8 hours after fish bile intake, suggesting that treatment should be initiated within a few hours after exposure. In acute oral poisoning, the preferred treatment is to remove toxic substances inside the body in time, which might assist in reducing the morbidity of victims 26‐28 . Patients can be purified utilizing haemodialysis to remove toxins in the blood apart from emesis, gastric lavage and catharsis 29 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of factors related to prognosis and death of fish bile poisoning in China: A retrospective study

Yan

Wang

et al. 2020

Basic Clin Pharma Tox

Self Cite

View full text Add to dashboard Cite

Ingestion of fish bile is believed to have medicinal properties and has been used in folk medicine in China, India, Japan and other Southeast Asian countries. 1-4 As early as in 1573, the famous ancient Chinese medicine book Compendium of Materia Medica recorded that the fish bile of black carp can treat eye diseases. 5 Some people believe the folk prescription recorded in the old books which indicate fish bile intake may benefit throat pain, hypertension, tracheitis, asthma, skin pruritus and improving eyesight. 6 However, individuals who consume fish bile, especially those living in rural areas, sporadically suffer from the toxicity of fish bile with acute renal failure and liver injury. 2 Besides, the ingestion of fish bile damages the heart and gastrointestinal tract and results in multiple organ dysfunction syndromes and occasional death. Although several studies have initiated to identify the toxic substances in fish bile, no standard recommendations

show abstract

“…CircRNAs were previously considered as products derived from erroneous splicing events during posttranscriptional processing and to have low abundance and little functional potential [2]. However, accumulating evidence has recently shown that circRNAs are widespread and diverse throughout eukaryotic cells and that they have multiple biological functions and play potentially important roles in various diseases, such as neurodegenerative diseases and cancer [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Exploring the regulatory roles of circular RNAs in Alzheimer’s disease

Zhang

Zhao

Liu

et al. 2020

Transl Neurodegener

View full text Add to dashboard Cite

Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play critical roles in Alzheimer’s disease (AD) and may have therapeutic potentials for this disease. CircRNAs play regulatory roles in neural functions and neurological disorders through diverse mechanisms, including acting as microRNA sponges or interacting with proteins to regulate selective splicing or transcription, as well as through epigenetic modification. In this review, we discuss the biogenesis and functions of circRNAs and the research progress on circRNAs in AD to advance the understanding of how circRNAs contribute to this neurological disorder.

show abstract

Current status and potential role of circular RNAs in neurological disorders

Cited by 45 publications

References 124 publications

Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population

Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population

Analysis of factors related to prognosis and death of fish bile poisoning in China: A retrospective study

Exploring the regulatory roles of circular RNAs in Alzheimer’s disease

Contact Info

Product

Resources

About