CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression

Su, Yang; Lv, Xiurui; Yin, Wei; Zhou, Lingling; Hu, Yilin; Zhou, Ang; Qi, Fuzhen

doi:10.18632/aging.102312

Cited by 160 publications

(103 citation statements)

References 57 publications

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“…Cancer cachexia results in functional impairment, decreased physical ability and it is associated with a poor prognosis (89). The same mechanisms have been reported in other studies (90,91). It can be concluded from the aforementioned studies that exosomes can directly transfer circRNAs from cancer cells to surrounding cells, and then further mediate the biological functions of recipient cells.…”

Section: Exosomes Containing Circrnas Function In Promoting or Inhibisupporting

confidence: 54%

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

et al. 2020

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Exosomes are nanoscale phospholipid bilayer vesicles that can be artificially engineered into vectors for the treatment of cancer. Circular RNA (circRNA), a type of non-coding RNA, has crucial regulatory functions in various aspects of cancer, such as tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemo-and radiotherapeutic resistance, as well as in cancer prognosis. Notably, the exosomal transfer of circRNAs may function to both promote and inhibit cancer. Numerous studies have addressed the importance of circRNAs in cancer and non-coding RNAs (such as microRNAs and long non-coding RNAs) in exosomes. However, little research has focussed on a class of RNAs called exosomal circRNAs. The present review discusses current studies regarding exosomal circRNAs, including their biogenesis and biological functions, their abundance in exosomes and possible sorting mechanisms and their potential roles in both promoting and inhibiting cancer. It is predicted that in the next five years there will be increasing research exploring the functional mechanisms of exosomal circRNA in various diseases, in particular their roles in cancer genesis and progression.

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Section: Exosomes Containing Circrnas Function In Promoting or Inhibisupporting

confidence: 54%

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

et al. 2020

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“…25 Inversely, Su et al pronounce that circ_CDR1as is highly expressed in HCC cells and tissues, and gain of circ_CDR1as largely promotes HCC cells to proliferate and metastasize, as well as accelerates HCC progression, highlighting its oncogenic role. 11 What is more, Xu et al point out that the expression level of circ_CDR1as in HCC and matched non-tumor tissues is comparable. 26 From our data, we also discover that circ_CDR1as expression is significantly upregulated in HCC tissues and cells.…”

Section: Discussionmentioning

confidence: 99%

“…10 As for circ_CDR1as, it has been identified to be an oncogene to accelerate HCC progression. 11 However, the specific actin mechanism of circ_CDR1as in HCC development has not been fully illuminated yet.…”

Section: Introductionmentioning

confidence: 99%

<p>CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway</p>

Zhang¹,

Li²,

Zhu³

et al. 2020

CMAR

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Background: Hepatocellular carcinoma (HCC) is a common lethal malignant tumor worldwide. Circular RNAs (circRNAs) have been reported to affect the development of human cancers, including HCC. In this project, we aim to clarify the functional effect of circular CDR1as (circ_CDR1as) on HCC progression. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot is implemented to detect the expression of circ_CDR1as, microRNA (miR)-1287 and Raf-1 proto-oncogene, serine/threonine kinase (Raf1). Cell proliferation is assessed via colony formation and 3-(4, 5)-dimethylthiazole-2-y1)-2, 5-biphenyl tetrazolium bromide (MTT) assays. Cell migration and invasion are measured by Transwell assay. The target relationship between miR-1287 and circ_CDR1as or Raf1 is validated through dual-luciferase reporter assay. The levels of epithelia-mesenchymal transition (EMT) markers and the MEK/ERK signal pathway-related proteins are examined by Western blot. Model in nude mice is constructed to determine the role of circ_CDR1as in vivo. Results: Expression of circ_CDR1as and Raf1 is elevated, while miR-1287 expression is decreased in HCC. Depletion of circ_CDR1as or Raf1 could inhibit proliferation and metastasis of HCC cells. Besides, circ_CDR1as regulates Raf1 expression by targeting miR-1287. MiR-1287 upregulation or Raf1 depletion could partially counterbalance circ_CDR1as depletion-mediated inhibitory effects on HCC cell behaviors. Moreover, circ_CDR1as depletion represses HCC progression through inactivating MEK/ERK pathway. In addition, circ_CDR1as depletion suppresses tumor growth in vivo via regulating miR-1287/Raf1 pathway. Conclusion: Circ_CDR1as depletion inhibits HCC cell proliferation and metastasis by miR-1287/Raf1 and MEK/ERK pathways, highlighting a promising molecular target for HCC treatment.

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“…circRNA CDR1as, also known as ciRS‐7, functions as an oncogenic or suppressive regulator in multiple cancer progression and chemoresistance, such hepatocellular carcinoma (HCC; Su et al, 2019), ovarian cancer (Zhao, Ji, Wang, He, & Li, 2019), bladder cancer (Yuan et al, 2019), and nasopharyngeal carcinoma (Q. Zhong et al, 2019). Similarly, through systematic and comprehensive pan‐cancer analysis, CDR1as was proved to play a specific role in alternation of the tumor microenvironment by regulation of the TGF‐β pathway and extracellular matrix (ECM)‐receptor interaction (Zou et al, 2019).…”

Section: Circrnas In Osteosarcomamentioning

confidence: 99%

Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma

et al. 2020

Journal Cellular Physiology

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Osteosarcoma represents the most prevailing primary bone tumor and the third most common cancer in children and adolescents worldwide. Among noncoding RNAs, circular RNAs (circRNAs) refer to a unique class in the shape of a covalently closed continuous loop with neither 5′ caps nor 3′‐polyadenylated tails, which are generated through back‐splicing. Recently, with the development of whole‐genome and transcriptome sequencing technologies, a growing number of circRNAs have been found aberrantly expressed in multiple diseases, including osteosarcoma. circRNA are capable of various biological functions including miRNA sponge, mediating alternatives, regulating genes at posttranscriptional levels, and interacting with proteins, indicating a pivotal role of circRNA in cancer initiation, progression, chemoresistance, and immune response. Moreover, circRNAs have been thrust into the spotlight as potential biomarkers and therapeutic targets in osteosarcoma. Herein, we briefly summarize the origin and biogenesis of circRNA with current knowledge of circRNA in tumorigenesis of osteosarcoma, aiming to elucidate the specific role and clinical implication of circRNAs in osteosarcoma.

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CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression

Cited by 160 publications

References 57 publications

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)

<p>CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway</p>

Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma

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