CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis

Osteoporosis is one bone disease characterized with skeletal impairment, bone strength reduced and fracture risk enhanced. [1][2][3][4] It is accompanied or asymptomatic by mild or serious symptoms, which is one cause of pathological fracture and also the high-risk factor influencing human health. [5][6][7] The incidence of osteoporosis is 70% in people over 80 years and 15% in people over 50 years old. 8,9 The osteoporosis patient's number exceeds 200 million worldwide at present, while the number may increase to 300 million as ageing population by 2023. 10 The modulation processes of bone metabolism are associated with several factors such as mechanical stimulation, epigenetic regulation and hormones. [11][12][13][14][15] The major therapies of osteoporosis are drug therapy and surgery, while the curative effect remains unsatisfactory. [16][17][18] Thus, it is crucial to find new biomarkers for the indention and therapy of osteoporosis.Circular RNAs (circRNAs) are formed by reverse splicing of splice accepter at 5′ end splice donor at the 3′ end in the pre-mRNA. [19][20][21][22] cir-cRNAs are one group of noncoding RNA and temporal, disease specific and spatial are expressed in several tissues and cells and can be acted as therapeutic targets and biomarkers. [23][24][25][26] Although circRNAs are mostly located in cytoplasm, some circRNAs containing introns are originated from nucleus. 27 CircRNAs have several functions including regulating gene transcription, regulating translation, modulating alternative splicing, functioning as miRNA sponges and interacting with RBPs (RNAbinding proteins). [28][29][30][31][32] Growing evidence suggested that circRNAs play crucial roles in cell functions such as cell metabolism, differentiation, proliferation, apoptosis and invasion. 19,[33][34][35][36] Increasing studies showed that circRNAs involved in the development of many diseases including cancers, neurological diseases, congenital diseases, intervertebral disc degeneration and endocrine diseases. [37][38][39][40][41][42][43] Recently, studies indicated that circRNAs also play important roles in osteoporosis. 44

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“…Liu et al 68 demonstrated that circHmbox1 level was decreased in the TNF-a-treated osteoclast formation in vitro and in vivo.…”

Section: Circhmbox1mentioning

confidence: 99%

“…Liu et al 68 demonstrated that circHmbox1 level was decreased in the TNF‐a‐treated osteoclast formation in vitro and in vivo. CircHmbox1 suppressed RANKL‐induced BMMs osteoblasts differentiation partly via binding to miR‐1247‐5p.…”

Section: Mechanisms Of Action Of Functionally Important Circrnas In Scimentioning

confidence: 99%

Emerging roles of circular RNAs in osteoporosis

Chen

Zhang

Chang

2021

J Cellular Molecular Medi

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“…Overexpression of circHmbox1 remarkably mitigates the osteoporotic phenotypes in ovariectomized mice, which might function as a promising treatment strategy for postmenopausal osteoporosis. 405 …”

Section: The Roles Of Exosomal Ncrnas In Human Diseasesmentioning

confidence: 99%

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

et al. 2021

Sig Transduct Target Ther

199

127

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Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.

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“…Conversely, the overexpression of circ_0007059 reduced hBMSC differentiation into osteoclasts and bone morphogenetic protein 2 (BMP-2) in vitro by directly targeting miR-378 [ 103 ]. Liu et al have demonstrated that circHmbox1 could also suppress RANKL-induced osteoclasts differentiation by binding to miR-1247-5p [ 104 ].…”

Section: The Role Of Molecules In Osteoclast Regulationmentioning

confidence: 99%

Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis

Zhao

Patil

et al. 2021

Biomolecules

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Osteoclasts (OCs) are important cells that are involved in the regulation of bone metabolism and are mainly responsible for coordinating bone resorption with bone formation to regulate bone remodeling. The imbalance between bone resorption and formation significantly affects bone metabolism. When the activity of osteoclasts exceeds the osteoblasts, it results in a condition called osteoporosis, which is characterized by reduced bone microarchitecture, decreased bone mass, and increased occurrences of fracture. Molecules, including transcription factors, proteins, hormones, nucleic acids, such as non-coding RNAs, play an important role in osteoclast proliferation, differentiation, and function. In this review, we have highlighted the role of these molecules in osteoclasts regulation and osteoporosis. The developed therapeutics targeting these molecules for the treatment of osteoporosis in recent years have also been discussed with challenges faced in clinical application.

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CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis

Cited by 40 publications

References 26 publications

Emerging roles of circular RNAs in osteoporosis

Emerging roles of circular RNAs in osteoporosis

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Role of Biomolecules in Osteoclasts and Their Therapeutic Potential for Osteoporosis

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