Circadian rhythms of four marker enzymes activity of the jejunal villi in man

Markiewicz, A; Kamisńki, Marcin; Chociłowski, Witold; Gomoluch, T; Bołdys, H; Skrzypek, Barbara

doi:10.1016/s0065-1281(83)80015-4

Cited by 11 publications

(2 citation statements)

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“…Rao et al ( 25 ) determined a significant increase in colonic pressure activity after awakening. Other physiologically relevant factors, such as absorption rhythms ( 26 ) and mucosal enzymes ( 27 ), also exhibited their lowest activities at night ( Fig. 2 ).…”

Section: The Intestine Harbours a Circadian Clockmentioning

confidence: 99%

Circadian clock as a possible control point in colorectal cancer progression (Review)

Rao

Lin

2022

Int J Oncol

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The circadian rhythm is generated at the cellular level by a molecular clock system that involves specific genes. Studies have revealed that circadian clock disruption is a control point in cancer progression. Colorectal cancer (CRC) is one of the cancers closely associated with circadian disruption. In the present review, the involvement of the circadian clock in CRC development was summarized. Abnormal expression of certain clock genes has been found in patients with CRC and their correlation with clinicopathological features has also been explored. The period and cryptochrome 2 (Cry2), Sirtuin1 (SIRT1) and neuronal PAS domain protein 2 (NPAS2) genes were reported to have tumour suppressor properties. Conversely, Cry1, brain and muscle ARNT-like-1, circadian locomotor output cycles kaput (CLOCK) and timeless may aggravate CRC progression, but these findings are not consistent and require to be confirmed by further research. Circadian scheduling also indicated advantages in chemotherapy treatments for patients with CRC by increasing the maximum tolerated doses and decreasing toxicities. Dysfunction of the molecular CLOCK system disrupted cellular processes to accelerate colon tumorigenesis, such as metabolism, cell cycle, DNA damage repair, proliferation and apoptosis, epithelial-mesenchymal transition and stemness. The clock gene network and how the dynamics of the system influence CRC were discussed.

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Section: The Intestine Harbours a Circadian Clockmentioning

confidence: 99%

Circadian clock as a possible control point in colorectal cancer progression (Review)

Rao

Lin

2022

Int J Oncol

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“…1). They originate from the brush-border epithelium ( 33 , 34 ) , pancreas ( 35 ) and bile ( 36 ) . The duodenum has the most developed absorptive capacity for nucleosides ( 37 ) .…”

Section: Biochemical and Functional Characteristics Of Nucleotidesmentioning

confidence: 99%

The role of dietary nucleotides in single-stomached animals

2011

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The transition from liquid to solid feed during weaning results in morphological, histological and microbial changes in the young animal's intestinal tract and often is associated with diarrhoea. The ban of in-feed antibiotics in pig production in the European Union has led to increasing interest in alternatives to overcome weaning-associated problems. Among others, nucleotides may have the potential to alleviate health impairments due to weaning. Nucleotides are natural components of the non-protein fraction of milk and have important effects on the maintenance of health in young animals. Nucleotides and their related metabolic products play key roles in many biological processes and become essential dietary components when endogenous supply is insufficient for normal function. The present review summarises nucleotide composition of milk from different species, the biology of nucleotides and possible effects of dietary nucleotides on intestinal morphology and function, intestinal microbiota, immune function, nutrient metabolism, hepatic morphology and function as well as growth performance. Special attention is given to data available for pigs, and suggestions are made for inclusion of nucleotides in the diet to benefit piglets' health and reduce the consequences accompanying early weaning.

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