Circadian rhythm of cellular proliferation in the human rectal mucosa

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

“…However, the turnover rate is not always constant. For example, gut EC proliferation rates undergo circadian fluctuation in rodents 2,3 and humans 4,5 , which alters the morphology and function of the GI tract. In the normal human rectal biopsies, 3 H-thymidine incorporation into cells is higher at night and lower in the afternoon 5 .…”

Comparison of the Eight-Hour With the 22-Hour Infusion of 5-Fluorouracil, in the FOLFOX Chemotherapy of Colon Cancer: A Retrospective Study

“…Pharmacodynamic differences in host drug sensitivity may have a circadian pattern (19,20). Clearance of 5-FU by drug-metabolizing enzymes has time-dependent changes (21)(22)(23).…”

Chronobiology of and Chronotherapy for Rheumatoid Arthritis

“…Body temperature 18:00-20:00 3:00-6:00 Lack et al, 2008 2 Heart rate 8:00-18:00 4:00-6:00 Clarke et al, 1976 3 Blood pressure 8:00-20:00 0:00-6:00 Degaute et al, 1991 4 Hepatic blood flow 8:00 14:00 Lemmer et al, 1991 5 Glomerular filtration 16:00 4:00 Koopman et al, 1989 6 Lymphocytes 12:00-17:00 7:00 Miyawaki et al, 1984 7 Cortisol Adiponectin Leptin-binding protein 8:00-13:00 8:00-13:00 8:00-14:00 0:00-4:00 2:00-4:00 1:00-5:00 Gavrila et al, 2003 8 Melatonin 2:00-4:00 9:00-21:00 Kennaway et al, 1998 9 DNA synthesis in the bone marrow 16:00 0:00 Smaaland et al, 1991 10 DNA synthesis in the rectal mucosa 7:00 19:00 Buchi et al, 1991 These circadian rhythms are also associated with the risk or frequency of disease occurrence (Table 2). For example, asthma attacks get worse between midnight and early morning and www.intechopen.com are seldom observed in the daytime ( Fig.2; Dethlefsen et al, 1985).…”