Circadian clock as a possible control point in colorectal cancer progression (Review)

Rao, Xiwu; Lin, Lizhu

doi:10.3892/ijo.2022.5439

Cited by 13 publications

(7 citation statements)

References 112 publications

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“…Seemingly contradictory findings were reported for BMAL1, which was shown to act both as an oncogene, as well as a tumour suppressor. This dual function of BMAL1 on carcinogenesis was also observed for other cancer entities such as colorectal cancer 34 .…”

Section: Impact Of the Circadian Clock On Gbm Cell Proliferation And ...supporting

confidence: 64%

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

Nelson,

Relógio

2024

npj Precis. Onc.

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Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand glioblastoma biology on other levels and use these learnings for the development of new therapeutic concepts. Mounting evidence in the field of circadian medicine points to a tight interplay between disturbances of the circadian system and glioblastoma progression. The circadian clock, an internal biological mechanism governing numerous physiological processes across a 24-h cycle, also plays a pivotal role in regulationg key cellular functions, including DNA repair, cell cycle progression, and apoptosis. These processes are integral to tumour development and response to therapy. Disruptions in circadian rhythms can influence tumour growth, invasion, and response to treatment in glioblastoma patients. In this review, we explore the robust association between the circadian clock, and cancer hallmarks within the context of glioblastoma. We further discuss the impact of the circadian clock on eight cancer hallmarks shown previously to link the molecular clock to different cancers, and summarize the putative role of clock proteins in circadian rhythm disturbances and chronotherapy in glioblastoma. By unravelling the molecular mechanisms behind the intricate connections between the circadian clock and glioblastoma progression, researchers can pave the way for the identification of potential therapeutic targets, the development of innovative treatment strategies and personalized medicine approaches. In conclusion, this review underscores the significant influence of the circadian clock on the advancement and understanding of future therapies in glioblastoma, ultimately leading to enhanced outcomes for glioblastoma patients.

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Section: Impact Of the Circadian Clock On Gbm Cell Proliferation And ...supporting

confidence: 64%

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

Nelson,

Relógio

2024

npj Precis. Onc.

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“…According to earlier research, chemotherapy and TIMELESS are highly connected in several types of human cancer [ 46 , 47 ]. TIMELESS is significantly connected with the susceptibility of numerous anti-cancer targeted treatment medications, including fludarabine, lapatinib, and 6-mercaptopurine, as this study’s findings have shown.…”

Section: Discussionmentioning

confidence: 99%

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Yang,

Tang,

Lin

et al. 2023

Eur J Med Res

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Background The gene TIMELESS, which is involved in the circadian clock and the cell cycle, has recently been linked to various human cancers. Nevertheless, the association between TIMELESS expression and the prognosis of individuals afflicted with pan-cancer remains largely unknown. Objectives The present study aims to exhaustively scrutinize the expression patterns, functional attributes, prognostic implications, and immunological contributions of TIMELESS across diverse types of human cancer. Methods The expression of TIMELESS in normal and malignant tissues was examined, as well as their clinicopathologic and survival data. The characteristics of genetic alteration and molecular subtypes of cancers were also investigated. In addition, the relationship of TIMELESS with immune infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), and drug sensitivity was illustrated. Immunohistochemistry (IHC) was used to validate the expression of TIMELESS in clinical patients with several types of cancer. Results In contrast to the matching normal controls, most tumor types were found to often overexpress TIMELESS. Abnormal expression of TIMELESS was significantly related to more advanced tumor stage and poorer prognosis of breast cancer, as well as infiltrating immune cells such as cancer-associated fibroblast infiltration in various tumors. Multiple cancer types exhibited abnormal expression of TIMELESS, which was also highly correlated with MSI and TMB. More crucially, TIMELESS showed promise in predicting the effectiveness of immunotherapy and medication sensitivity in cancer therapy. Moreover, cell cycle, DNA replication, circadian rhythm, and mismatch repair were involved in the functional mechanisms of TIMELESS on carcinogenesis. Furthermore, immunohistochemical results manifested that the TIMELESS expression was abnormal in some cancers. Conclusions This study provides new insights into the link between the circadian gene TIMELESS and the development of various malignant tumors. The findings suggest that TIMELESS could be a prospective prognostic and immunological biomarker for pan-cancer.

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“…If the feedback loops are broken by irregular rest, diet or night shifts, the master switch of the normal circadian processes will become weak slowly. Then, the downstream pathophysiological processes are also out of control, such as cell cycle, cell apoptosis and cell metabolism, as well as invasion, metastasis and angiogenesis of CRC cells [10,31]. Circadian disruption and abnormal expression levels of circadian clock genes dysregulate these processes [6,32].…”

Section: The Effect Of Core Circadian Genes On Crcmentioning

confidence: 99%

“…Various physiological and pathological processes are closely related to circadian rhythm. Many studies [6][7][8][9] showed that circadian disruption was one of the endogenous factors resulting in tumour initiation and progression of various human malignancies, including colorectal cancer (CRC) [10,11]. CRC is one of the most common malignant tumours and the third most common cause of cancer death worldwide, with high morbidity and mortality [12,13].…”

Section: Introductionmentioning

confidence: 99%

Insight into immune checkpoint inhibitor therapy for colorectal cancer from the perspective of circadian clocks

et al. 2023

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Colorectal cancer (CRC) is one of the most common malignant tumours and the third most common cause of cancer deaths worldwide, with high morbidity and mortality. Circadian clocks are widespread in humans and temporally regulate physiologic functions to maintain homeostasis. Recent studies showed that circadian components were strong regulators of the tumour immune microenvironment (TIME) and the immunogenicity of CRC cells. Therefore, insight into immunotherapy from the perspective of circadian clocks can be promising. Although immunotherapy, especially immune checkpoint inhibitor (ICI) treatment, has been a milestone in cancer treatment, greater accuracy is still needed for selecting patients who will respond positively to immunotherapy with minimal side effects. In addition, there were few reviews focusing on the role of the circadian components in the TIME and the immunogenicity of CRC cells. Therefore, this review highlights the crosstalk between the TIME in CRC and the immunogenicity of CRC cells based on the circadian clocks. With the goal to achieve the possibility that patients with CRC can benefit most from the ICI treatment, we provide potential evidence and a novel idea for building a predictive framework combined with circadian factors, searching for enhancers of ICIs targeting circadian components and clinically implementing the timing of ICI treatment for patients with CRC.

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Circadian clock as a possible control point in colorectal cancer progression (Review)

Cited by 13 publications

References 112 publications

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Insight into immune checkpoint inhibitor therapy for colorectal cancer from the perspective of circadian clocks

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