Ciprofloxacin reduces the risk of hemolytic uremic syndrome in patients with Escherichia coli O104:H4-associated diarrhea

Geerdes-Fenge, H.; Löbermann, Micha; Nürnberg, M.; Fritzsche, Carlos; Koball, Sebastian; Henschel, J.; Hohn, R B; Schober, Hans-Christof; Mitzner, Steffen; Podbielski, Andreas; Reisinger, Erich

doi:10.1007/s15010-012-0387-6

Cited by 39 publications

(25 citation statements)

References 15 publications

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“…[15][16][17] However, recent reports during a German outbreak established new evidence regarding antibiotic usage. [18][19][20] In conclusion, Acinetobacter infection should be considered as a plausible cause of typical HUS in cases with no E. coli infection. The high frequency and degree of adaptability and transformability among some strains of Acinetobacter spp.…”

Section: Discussionmentioning

confidence: 91%

Hemolytic uremic syndrome associated withAcinetobacter hemolyticus

Silva

Lipinski

2014

Renal Failure

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Shiga toxin-producing Escherichia coli and Shigella dysenteriae have been associated with bloody diarrhea and hemolytic uremic syndrome (HUS) in humans. However, there have been only a couple of reports describing bloody diarrhea associated with Acinetobacter spp. and there are no reports of these bacteria causing HUS in children. Here, we report the case of a nine-month-old boy with bloody diarrhea who developed non-oliguric renal failure. The clinical and laboratory findings supported the diagnosis of Acinetobacter hemolyticus infection associated with HUS. The patient responded favorably to antibiotic therapy plus conservative treatment. In conclusion, Acinetobacter infection should be considered as a plausible cause of HUS in cases where E. coli infection is not involved. The rapid transformation ability of Acinetobacter is a matter of concern.

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Section: Discussionmentioning

confidence: 91%

Hemolytic uremic syndrome associated withAcinetobacter hemolyticus

Silva

Lipinski

2014

Renal Failure

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“…Exposure to antibiotics also increases the risk of HUS in children (114). However, recent data demonstrated that treatment with ciprofloxacin reduced the risk of HUS in patients infected with the 2011 German O104 STEC strain (116). These data are supported by a recent meta-analysis of studies between 1980 and 2011 (117).…”

Section: Escherichia Colimentioning

confidence: 90%

Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Bacterial Gastroenteritis

2015

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SUMMARY Bacterial gastroenteritis is a disease that is pervasive in both the developing and developed worlds. While for the most part bacterial gastroenteritis is self-limiting, identification of an etiological agent by bacterial stool culture is required for the management of patients with severe or prolonged diarrhea, symptoms consistent with invasive disease, or a history that may predict a complicated course of disease. Importantly, characterization of bacterial enteropathogens from stool cultures in clinical laboratories is one of the primary means by which public health officials identify and track outbreaks of bacterial gastroenteritis. This article provides guidance for clinical microbiology laboratories that perform stool cultures. The general characteristics, epidemiology, and clinical manifestations of key bacterial enteropathogens are summarized. Information regarding optimal specimen collection, transport, and processing and current diagnostic tests and testing algorithms is provided. This article is an update of Cumitech 12A (P. H. Gilligan, J. M. Janda, M. A. Karmali, and J. M. Miller, Cumitech 12A, Laboratory diagnosis of bacterial diarrhea, 1992).

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“…Therefore, bacteremia during EHEC infection represents a new therapeutic challenge. However, a 2011 outbreak in Germany linked to EHEC O104:H4 ( 13 ) underscored the potential benefit of certain antibiotics when HUS occurs ( 14 , 15 ). Thus, the use of antibiotics during EHEC infections remains a source of debate ( 2 , 16 ).…”

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confidence: 99%

EnterohemorrhagicEscherichia coliHybrid Pathotype O80:H2 as a New Therapeutic Challenge

Soysal¹,

Mariani‐Kurkdjian²,

Smail³

et al. 2016

Emerg. Infect. Dis.

107

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Ciprofloxacin reduces the risk of hemolytic uremic syndrome in patients with Escherichia coli O104:H4-associated diarrhea

Abstract: In our E. coli O104:H4-infected patients, treatment of diarrhea with antibiotics did not increase the risk of HUS. Significantly fewer patients treated with ciprofloxacin developed HUS than patients who did not receive ciprofloxacin.

Cited by 39 publications

References 15 publications

Hemolytic uremic syndrome associated withAcinetobacter hemolyticus

Hemolytic uremic syndrome associated withAcinetobacter hemolyticus

Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Bacterial Gastroenteritis

EnterohemorrhagicEscherichia coliHybrid Pathotype O80:H2 as a New Therapeutic Challenge

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