Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis

Hagenlocher, Yvonne; Satzinger, Sabrina; Civelek, Mehtap; Feilhauer, Katharina; Köninger, Jörg; Bischoff, Stephan C.; Lorentz, Axel

doi:10.1002/mnfr.201601085

Cited by 25 publications

(20 citation statements)

References 50 publications

(77 reference statements)

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“…For cinnamon extract, several beneficial health effects are reported in literature, e.g. anti-inflammatory effects on murine alcohol-induced steatosis and colitis [ 62 – 64 ]. Ethanolic cinnamon bark extracts have been shown to suppress release of TNF-α, IL-1β and IL-6 and NF-κB activation, in line with our data [ 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects

et al. 2018

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Herbal extracts represent an ample source of natural compounds, with potential to be used in improving human health. There is a growing interest in using natural extracts as possible new treatment strategies for inflammatory diseases. We therefore aimed at identifying herbal extracts that affect inflammatory signaling pathways through toll-like receptors (TLRs), TLR2 and TLR4. Ninety-nine ethanolic extracts were screened in THP-1 monocytes and HeLa-TLR4 transfected reporter cells for their effects on stimulated TLR2 and TLR4 signaling pathways. The 28 identified anti-inflammatory extracts were tested in comparative assays of stimulated HEK-TLR2 and HEK-TLR4 transfected reporter cells to differentiate between direct TLR4 antagonistic effects and interference with downstream signaling cascades. Furthermore, the ten most effective anti-inflammatory extracts were tested on their ability to inhibit nuclear factor-κB (NF-κB) translocation in HeLa-TLR4 transfected reporter cell lines and for their ability to repolarize M1-type macrophages. Ethanolic extracts which showed the highest anti-inflammatory potential, up to a complete inhibition of pro-inflammatory cytokine production were Castanea sativa leaves, Cinchona pubescens bark, Cinnamomum verum bark, Salix alba bark, Rheum palmatum root, Alchemilla vulgaris plant, Humulus lupulus cones, Vaccinium myrtillus berries, Curcuma longa root and Arctostaphylos uva-ursi leaves. Moreover, all tested extracts mitigated not only TLR4, but also TLR2 signaling pathways. Seven of them additionally inhibited translocation of NF-κB into the nucleus. Two of the extracts showed impact on repolarization of pro-inflammatory M1-type to anti-inflammatory M2-type macrophages. Several promising anti-inflammatory herbal extracts were identified in this study, including extracts with previously unknown influence on key TLR signaling pathways and macrophage repolarization, serving as a basis for novel lead compound identification.

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Section: Discussionmentioning

confidence: 99%

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects

et al. 2018

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“…The preferred cinnamon species in food industry is Cinnamomum verum, whereas in the pharmaceutical industry, Cinnamomum cassia and Cinnamomum verum are used interchangeably. 15 From current literature, cinnamon extract is known to possess anti-inflammatory effects in a mouse model of alcohol-induced fatty liver, on colitis in mice with IL-10 knockout, [16][17][18] in models of arthritis and diabetes 19,20 and in experimental autoimmune encephalitis (EAE), a model of multiple sclerosis. 21 Ethanolic extracts of Cinnamomum verum have shown anti-inflammatory properties by suppression of nitric oxide (NO), TNF-α, IL-1β and IL-6 production as well as blocking the activation of NF-κB in different LPS-stimulated cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

et al. 2018

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“…Besides its anti‐allergic property, cinnamon has also been described to possess anti‐inflammatory effects in a number of mouse models such as inflammatory bowel disease, arthritis, diabetes, alcohol‐induced fatty liver and experimental autoimmune encephalitis . Anti‐inflammatory properties of CE are mediated by suppression of nitric oxide (NO), TNF‐α, IL‐1β and IL‐6 production as well as by blocking mitogen‐activated protein kinase (MAPK) and nuclear factor‐ĸB (NF‐ĸB) activation .…”

Section: Discussionmentioning

confidence: 99%

Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Ose

Schink

et al. 2019

Clin Experimental Allergy

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Background Ceylon cinnamon has been shown to possess anti‐inflammatory properties in many diseases including allergic inflammation. Objective The aim of this study was to analyse in more detail the effects of cinnamon extract (CE) and its major compounds p‐cymene and trans‐cinnamaldehyde (CA) on allergen‐specific immune responses in vitro and in vivo. Methods Therefore, monocyte‐derived mature dendritic cells (DC) from grass or birch pollen allergic donors were pulsed with the respective allergen in the presence or absence of CE, p‐cymene, CA or the solvent ethanol and co‐cultured with autologous CD4+ T cells. Furthermore, basophil activation test was performed with or without CE or ethanol treatment. For the in vivo experiments, BALB/c mice were immunized with ovalbumin (OVA) and orally treated with CE or ethanol. Results Addition of CE, p‐cymene or CA, but not ethanol significantly inhibited DC maturation and subsequent allergen‐specific T cell proliferation as well as Th1 and Th2 cytokine production. Sulphidoleukotriene release and CD63 expression by basophils were also significantly diminished after addition of CE. In vivo, treatment of OVA‐sensitized mice with CE led to a significant shift from OVA‐specific IgE towards IgG2a production and to a strong inhibition of OVA‐specific proliferation. Moreover, airway inflammation as well as anaphylaxis after intranasal or systemic allergen challenge was significantly reduced in CE‐treated mice. Furthermore, topical application of CE prevented calcipotriol‐induced atopic dermatitis‐like inflammation in these mice. Conclusions and Clinical Relevance Taken together, our data indicate that the anti‐inflammatory effect of cinnamon might be exploited for treatment of allergic inflammation, which needs to be further investigated.

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Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis

Abstract: Cinnamon decreases fibrotic symptoms and markers in murine colitis, and expression of inflammatory and fibrotic markers in hiFB. Thus, CE and CA could be potential anti-fibrotic agents in chronic colitis.

Cited by 25 publications

References 50 publications

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

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