Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Abstract

Background Ceylon cinnamon has been shown to possess anti‐inflammatory properties in many diseases including allergic inflammation. Objective The aim of this study was to analyse in more detail the effects of cinnamon extract (CE) and its major compounds p‐cymene and trans‐cinnamaldehyde (CA) on allergen‐specific immune responses in vitro and in vivo. Methods Therefore, monocyte‐derived mature dendritic cells (DC) from grass or birch pollen allergic donors were pulsed with the respective allergen in the presence or absence of CE, p‐cymene, CA or the solvent ethanol and co‐cultured with autologous CD4+ T cells. Furthermore, basophil activation test was performed with or without CE or ethanol treatment. For the in vivo experiments, BALB/c mice were immunized with ovalbumin (OVA) and orally treated with CE or ethanol. Results Addition of CE, p‐cymene or CA, but not ethanol significantly inhibited DC maturation and subsequent allergen‐specific T cell proliferation as well as Th1 and Th2 cytokine production. Sulphidoleukotriene release and CD63 expression by basophils were also significantly diminished after addition of CE. In vivo, treatment of OVA‐sensitized mice with CE led to a significant shift from OVA‐specific IgE towards IgG2a production and to a strong inhibition of OVA‐specific proliferation. Moreover, airway inflammation as well as anaphylaxis after intranasal or systemic allergen challenge was significantly reduced in CE‐treated mice. Furthermore, topical application of CE prevented calcipotriol‐induced atopic dermatitis‐like inflammation in these mice. Conclusions and Clinical Relevance Taken together, our data indicate that the anti‐inflammatory effect of cinnamon might be exploited for treatment of allergic inflammation, which needs to be further investigated.

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“…Basil leave callus on the other hand revealed recently antioxidant activity linked to the production of chicoric acid and rosmarinic acid by the inhibition of reactive oxygen species (ROS) [136]. Cinnamon has been used to relieve many disease complications of humans [137]. Recent works show cinnamon's ability to produce compounds with root canal disinfection capabilities in dental applications [138].…”

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“…Also, some of the phenolic and non-phenolic and non-volatile compounds of cinnamon shells that have antioxidant properties include cinacacilli, beta-cystrol, epicatechin, creatinine, syringic acid, cinnamic acid, coumarin and vanillic acid (140). In a recent study by Robert Ossie et al, The addition of cinnamon supplementation significantly inhibited the maturation of DC dendritic cells and inhibited the proliferation of specific T cells, such as the production of Th1 and Th2 cytokines (141). The release of sulfidololcuterin and CD63 expression by basophils was also significantly reduced after the addition of ethanolic cinnamon extract (CE).…”

“…The release of sulfidololcuterin and CD63 expression by basophils was also significantly reduced after the addition of ethanolic cinnamon extract (CE). Treatment of OBA-sensitive mice (OVA) with CE resulted in a significant shift from OVAspecific IgE to IgG2a production and severe inhibition of specific OVA proliferation (141). In addition, inflammation of the airways as well as anaphylaxis is reduced after the challenge of intrauterine or systemic in mice treated with CE.…”

“…In general, the anti-inflammatory effect of cinnamon may be used to treat allergic inflammation (141).…”

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“…The main functions of CS Presl include tonifying fire and helping yang, dispersing cold and relieving pain, warming blood vessels, improving yang deficiency, and treating vertigo. 122,123 The medicinal value of CS Presl is mainly reflected in antihypertensive, 124 anti-allergy, 125 antibacterial, 126 and anticancer 127 activities; it is used in the treatment of PD 128 and type 2 diabetes 129 and it improves cognitive dysfunction. 130 In addition, it enhances blood circulation and calms and relieves pain, and it has auxiliary therapeutic effects in depression.…”