Cinnamon intake reduces serum T3 level and modulates tissue-specific expression of thyroid hormone receptor and target genes in rats

Abstract

This study has revealed that TH action is a novel target of cinnamon, demonstrating impairment of T3 signaling in the cardiac ventricles. © 2015 Society of Chemical Industry.

Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

“…Aqueous cinnamon extract was prepared with the bark of Cinnamomum zeylanicum , also known as Cinnamomum verum . All extract used were performed with the same batch of cinnamon bark purchased from a local seller and was prepared as described previously . Briefly, cinnamon bark was mechanically powdered; cinnamon powder was mixed with water (0.1 g mL −1 ) and incubated in a water bath at 60°C for 1 h. The extract obtained was centrifuged at 1000 × g for 5 min at 4°C and then the supernatant was collected and stored at –20°C.…”

“…During the 20‐day lactation period, cinnamon dams received an aqueous cinnamon extract (400 mg kg −1 body mass day −1 ) . The dosage was chosen based on body surface area to represent a human dose of 64 mg kg −1 body mass day −1 , which is the dose frequently used in human studies …”

“…5,12 Briefly, cinnamon bark was mechanically powdered; cinnamon powder was mixed with water (0.1 g mL −1 ) and incubated in a water bath at 60 ∘ C for 1 h. The extract obtained was centrifuged at 1000 × g for 5 min at 4 ∘ C and then the supernatant was collected and stored at -20 ∘ C. The extract was analyzed via high-performance liquid chromatography-diode array detection on the basis of UV spectra and using (+)-electrospray ionisation mass spectrometry (ESI-MS) and (-)-ESI-MS, as described previously. 5,12 The major peak obtained was characteristic of cinnamaldehyde, a frequent component found in the Cinnamomum genus and established as the fingerprint for the cinnamon extract used in this study. 27 In addition to cinnamaldehyde, the extract contained other compounds, such as cinnamic acid, gluconic acid, palmitic acid, linoleic acid, oleic acid and stearic acid.…”

“…In addition, cinnamon supplementation has been associated with a reduction of fat mass . Furthermore, in healthy animals, chronic cinnamon intake also leads to lower serum insulin, leptin and triiodothyronine levels . The exact mechanisms by which cinnamon exerts its effects are not fully understood; however, the biological effects of cinnamon have been associated with cinnamaldehyde, the major bioactive compound present in cinnamon, as well as with polyphenols …”

“…7,11 Furthermore, in healthy animals, chronic cinnamon intake also leads to lower serum insulin, leptin and triiodothyronine levels. 5,12 The exact mechanisms by which cinnamon exerts its effects are not fully understood; however, the biological effects of cinnamon have been associated with cinnamaldehyde, the major bioactive compound present in cinnamon, 13,14 as well as with polyphenols. 15 Several studies have tested commercial cinnamon extracts, which reflects the increasing usage of dietary supplements in alternative medicine.…”