Cinnamon: A Promising Natural Product Against COVID-19

Zareie, Azadeh; Soleimani, Davood; Askari, Gholamreza; Jamialahmadi, Tannaz; Guest, Paul C.; Bagherniya, Mohammad; Sahebkar, Amirhossein

doi:10.1007/978-3-030-71697-4_15

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Numerous studies have reported the advantages of cinnamon when used safely ( Ghosh et al, 2015 ; Pauline and Maddox, 2017 ; Santos and da Silva, 2018 ; Zare et al, 2019 ), for example, in the treatment of diabetes and as a natural antioxidant in foods. Furthermore, the active ingredients of cinnamon have been proven helpful in controlling and preventing the complications of coronavirus disease 2019 ( Prasanth et al, 2021 ; Zareie et al, 2021 ). Cinnamon provided whole or as an aqueous extract contains a different number of active agents with various antihyperglycemic actions, since hypoglycemic activity appears in both aqueous extract, and powdered bark ( Anderson et al, 2004 ; Verspohl et al, 2005 ; Kim et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials

Tung

Jiesisibieke³

et al. 2022

Front. Pharmacol.

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Purpose: Many evidence-based studies have indicated that cinnamon has therapeutic effects. However, it may not be entirely safe and its adverse effects may be ignored. The present umbrella review was conducted to elucidate the safety of cinnamon.Methods: Pertinent meta-analyses and systematic reviews of randomized controlled trials on cinnamon use in humans were identified by searching PubMed, EMBASE, and the Cochrane Library from their inception to September 15, 2021. All meta-analyses and systematic reviews on the safety or adverse effects of cinnamon were considered. PRISMA 2020 was used as the standard of reporting (PRISMA registration ID: 286746).Results: We identified three meta-analyses and one systematic review that described the safety of cinnamon. The quality of the meta-analysis and systematic reviews was evaluated using “Assessing the Methodological Quality of Systematic Reviews.” Their quality was rated as low in two (50%) instances and moderate in two (50%). There were no significant toxic- or side effects between cinnamon group and placebo group regardless of dose and duration.Conclusion: There is evidence to support that the use of cinnamon has no adverse reactions. It can improve the health status of patients as an adjuvant treatment. Future studies exploring better profile risks and protective factors for cinnamon use-related adverse effect are needed, in order that preventive approaches can be developed.

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Section: Discussionmentioning

confidence: 99%

Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials

Tung

Jiesisibieke³

et al. 2022

Front. Pharmacol.

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“…Cinnamon contains secondary metabolites, such as cinnamaldehyde, cinnamic acid, 2-hydroxycinnamaldehyde, 2-methoxycinnamaldehyde, and eugenol, and possesses potent anti-inflammatory effect by reducing pro-inflammatory IL6, IL-1β, and TNF-α and suppressing NF-ĸB-mediated COX-2 and iNOS pathways [ 114 ]. With regards to NSCLC, cinnamon extract was found to suppress invasion of A549 and H1299 cells by regulating the expression of FAK and ERK pathways [ 115 ].…”

Section: Natural Compounds Targeting Inflammation In Nsclcmentioning

confidence: 99%

Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing

et al. 2023

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Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers are NSCLC and about 16% are SCLC. For the past few years, there have been a lot of new advances in the management of NSCLC in terms of screening, diagnosis and treatment. Unfortunately, most of the NSCLCs are resistant to current treatments and eventually progress to advanced stages. In this perspective, we discuss some of the drugs that can be repurposed to specifically target the inflammatory pathway of NSCLC utilizing its well-defined inflammatory tumor microenvironment. Continuous inflammatory conditions are responsible to induce DNA damage and enhance cell division rate in lung tissues. There are existing anti-inflammatory drugs which were found suitable for repurposing in non-small cell lung carcinoma (NSCLC) treatment and drug modification for delivery via inhalation. Repurposing anti-inflammatory drugs and their delivery through the airway is a promising strategy to treat NSCLC. In this review, suitable drug candidates that can be repurposed to treat inflammation-mediated NSCLC will be comprehensively discussed together with their administration via inhalation from physico-chemical and nanocarrier perspectives.

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“…171 Also, higher consumption of fruits, vegetables and dietary fiber may lower the odds of contracting COVID-19. 172 Nutrients and minerals that may feature prominently include calcium, carotenoids, copper, fiber, folate, magnesium, manganese, potassium, iron, and vitamins A, B1, B6, C, and D. 171 There are also relatively inconclusive investigations about the potential of herbs and spices to help fight COVID-19. Ginger has been traditionally used as a natural remedy for respiratory infections, and studies have suggested that it may have antiviral activity against respiratory viruses, including SARS-CoV-2.…”

Section: Plant Sources Of Anti-sars-cov-2mentioning

confidence: 99%

The Global Impact of COVID-19: Historical Development, Molecular Characterization, Drug Discovery and Future Directions

Dofuor,

Quartey,

Osabutey

et al. 2023

Clin Med�Insights�Pathol

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In December 2019, an outbreak of a respiratory disease called the coronavirus disease 2019 (COVID-19) caused by a new coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China. The SARS-CoV-2, an encapsulated positive-stranded RNA virus, spread worldwide with disastrous consequences for people’s health, economies, and quality of life. The disease has had far-reaching impacts on society, including economic disruption, school closures, and increased stress and anxiety. It has also highlighted disparities in healthcare access and outcomes, with marginalized communities disproportionately affected by the SARS-CoV-2. The symptoms of COVID-19 range from mild to severe. There is presently no effective cure. Nevertheless, significant progress has been made in developing COVID-19 vaccine for different therapeutic targets. For instance, scientists developed multifold vaccine candidates shortly after the COVID-19 outbreak after Pfizer and AstraZeneca discovered the initial COVID-19 vaccines. These vaccines reduce disease spread, severity, and mortality. The addition of rapid diagnostics to microscopy for COVID-19 diagnosis has proven crucial. Our review provides a thorough overview of the historical development of COVID-19 and molecular and biochemical characterization of the SARS-CoV-2. We highlight the potential contributions from insect and plant sources as anti-SARS-CoV-2 and present directions for future research.

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Cinnamon: A Promising Natural Product Against COVID-19

Cited by 12 publications

References 32 publications

Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials

Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials

Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing

The Global Impact of COVID-19: Historical Development, Molecular Characterization, Drug Discovery and Future Directions

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