Ciliated hepatic foregut cyst

Deshmukh, Sanjay D; Pathak, Gayatri S; Joshi, Avinash R; Naik, Ajay

doi:10.4103/0377-4929.56150

Cited by 4 publications

(13 citation statements)

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“…These lesions are extremely rare in children and only 10 cases have been reported (Table 1) [1, 4–6, 12–15]. In pediatric population, including this report, five out of 12 cases (41.7%) were diagnosed antenatally and seven (58.3%) were detected postnatally.…”

Section: Discussionmentioning

confidence: 65%

“…Ciliated hepatic foregut cyst (CHFC), a rare foregut developmental malformation, usually presents as a solitary, unilocular, or occasionally multilocular cyst in the liver [1–9]. This congenital lesion is rare and is mostly diagnosed in adults, with estimated 100 cases reported in the world literature, many of them in Japan [1–3, 6–8, 10–12].…”

Section: Introductionmentioning

confidence: 99%

“…This congenital lesion is rare and is mostly diagnosed in adults, with estimated 100 cases reported in the world literature, many of them in Japan [1–3, 6–8, 10–12]. Only 10 cases were reported in children in our review of English medical literature [1, 4–6, 13–15]. Patients are usually asymptomatic and they are mostly detected incidentally on radiologic imaging or during surgical exploration.…”

Section: Introductionmentioning

confidence: 99%

“…Most CHFCs are well-delineated anechoic or slightly hypoechoic unilocular cysts on ultrasonography (US) and they are hypoattenuating or isoattenuating relative to liver parenchyma on enhanced computed tomographic scan (CT); however, radiology alone is not diagnostic [8]. Only histological features with a four-layered cyst wall, which consists of an inner ciliated, pseudostratified, columnar epithelium followed by subepithelial connective tissue, smooth muscle layer, and an outer layer fibrous tissue [1, 2, 4–7, 9, 10, 12, 15, 19], are characteristic of this lesion. We present two cases of CHFC in children because of their extreme rarity.…”

Section: Introductionmentioning

confidence: 99%

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Ciliated Hepatic Foregut Cyst: Two Case Reports in Children and Review of the Literature

Khoddami

Aghdam

Alvandimanesh

2013

Case Reports in Medicine

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Ciliated hepatic foregut cyst (CHFC) is a rare lesion which originates from detached hepatic diverticulum or from detachment and migration of buds from the esophageal and bronchial regions of the foregut which subsequently get entrapped by the liver during the early embryonic development of the foregut. CHFCs are mostly seen in adults and are rarely reported in children, with only about 10 cases reported in this age group. Hereby, we present two cases of CHFC in two 3.5-year-old boys; one of them had cystic lesion at medial segment of left lobe of liver (common site), and in the other one it was located at right lobe of liver (less common site). Histologically, both cysts had four layers composed of inner ciliated, pseudostratified, columnar epithelium; subepithelial connective tissue; smooth muscle layer; and an outer fibrous layer.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ciliated Hepatic Foregut Cyst: Two Case Reports in Children and Review of the Literature

Khoddami

Aghdam

Alvandimanesh

2013

Case Reports in Medicine

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“…Interestingly, our review of all pediatric cases revealed that approximately two thirds of the cysts in children were multilocular [2][3][4][5][6][7]11,13,15]. Three of our pediatric CHFCs were also multilocular.…”

Section: Discussionmentioning

confidence: 98%

Ciliated Hepatic Foregut Cyst: Four Case Reports with a Review of the Literature

et al. 2011

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Ciliated hepatic foregut cysts (CHFCs) are rare congenital legions that arise from the embryonic foregut. The cysts are formed during fetal development by evagination from their respective portions of the foregut, and are characterized by a ciliated epithelial lining. Approximately 100 cases of CHFC have been reported, of which only 13 were in children. Although CHFC is typically benign, malignant transformation to squamous cell carcinoma (SCC) has been reported in 3 cases. Survival rate after progression to malignancy is poor, as SCC in this setting is biologically aggressive. We present 4 new cases of CHFC in children between 5 months and 17 years old. Our cases are unusual, as some of the cysts exhibit multilocularity and biliary communication, and 2 of our patients were diagnosed under the age of 1. Additionally, 1 of the cysts was 19.3 cm in diameter, making it the largest reported CHFC to our knowledge. Ciliated hepatic foregut cysts should be included in the differential diagnosis of hepatic lesions.

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Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

et al. 2015

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BackgroundCiliated hepatic foregut cyst (CHFC) is a rare cystic lesion most commonly identified in segment 4 of the liver that arises from the embryonic foregut. The classic histologic pattern is comprised of 4 distinct layers (inner ciliated epithelial lining, smooth muscle, loose connective tissue, fibrous capsule). Although rare, cases of metaplastic and malignant epithelial lining have been described in CHFC.MethodsWe report 6 additional cases of CHFC, one of which had gastric metaplasia of the cyst lining, and review all reported cases of CHFC in the English literature. We describe the clinicopathologic analysis of 6 cases, with selective immunohistochemical analysis on 1 case with gastric metaplasia.ResultsCases occurred in 4 women and 2 men (average age 55 years, range 42 to 67 years). Cysts ranged in size from 0.7 to 17 cm (average 7.2 cm) and were grossly tan-pink to white with blood-filled contents. The majority were located in segment 4 of the liver, however 2 were located in the porta hepatis. Tumor serologies (CA19-9 and/or CEA) were performed in 3 cases; 1 case demonstrated elevated CA19-9, and 2 cases had laboratory values within normal limits. All cases showed the classic histologic findings, however one case additionally had extensive gastric metaplasia.ConclusionsIn conclusion, CHFC is a rare diagnostic entity that should be considered in the differential diagnosis for cystic hepatic lesions, particularly those located in segment 4 of the liver. Metaplasia and squamous carcinoma can occur, therefore complete surgical excision is the recommended treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-015-0321-1) contains supplementary material, which is available to authorized users.

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Ciliated hepatic foregut cyst

Cited by 4 publications

References 0 publications

Ciliated Hepatic Foregut Cyst: Two Case Reports in Children and Review of the Literature

Ciliated Hepatic Foregut Cyst: Two Case Reports in Children and Review of the Literature

Ciliated Hepatic Foregut Cyst: Four Case Reports with a Review of the Literature

Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature

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