Cigarette Smoking and Skin Prick Test in Patients With Allergic Rhinitis

Khazaei, Bahman; Dashtizadeh, Gholam Ali; Mohammadi, Mahdi

doi:10.5812/ijhrba.23483v2

Cited by 9 publications

(10 citation statements)

References 20 publications

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“…Thus, patients with AR exhibit signs of rhinorrhea, congestion, nasal itching, and obstruction. Consequently, affected subjects present systemic effects such as fatigue, sleepiness, and malaise, all contributing to an impaired quality of life (QoL) [7]. …”

Section: Introductionmentioning

confidence: 99%

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Karaulov

Vylegzhanina

Овчинников

et al. 2019

Int Arch Allergy Immunol

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Background: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR). Triamcinolone acetonide is a nasal corticosteroid preparation indicated for the treatment of seasonal and perennial AR (PAR) in different countries worldwide. Objectives: In order to determine the efficacy of triamcinolone acetonide in the treatment of PAR, the non-inferiority of triamcinolone acetonide to fluticasone propionate was assessed in Russian adults. Methods: In this randomized, double-blind, parallel-group, multicenter, prospective, non-inferiority, phase III clinical trial, a total of 260 patients with persistent PAR were randomized to receive either triamcinolone acetonide or fluticasone propionate nasal sprays for 4 weeks. The efficacy in symptom control was evaluated using the reflective total nasal symptom score (rTNSS) from baseline (day 0) to day 28. Safety was assessed through the reporting of adverse events. Results: The rTNSS mean values decreased from baseline to the end of study treatment (day 28) in both groups: –8.2 ± 3.0 in the triamcinolone acetonide arm versus –8.0 ± 2.8 in the fluticasone propionate arm. The mean difference between the groups (triamcinolone acetonide – fluticasone propionate) for rTNSS change from baseline was –0.2 (95% confidence interval –0.89 to 0.54), with an upper confidence limit of 0.54, which is lower than the non-inferiority margin of 0.8. Triamcinolone acetonide was well tolerated, with no difference in adverse event occurrence compared with fluticasone propionate. Conclusions: Triamcinolone acetonide proved to be non-inferior to fluticasone propionate in adult patients with PAR; both treatments decreased rTNSS values and showed a good safety profile.

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Section: Introductionmentioning

confidence: 99%

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Karaulov

Vylegzhanina

Овчинников

et al. 2019

Int Arch Allergy Immunol

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“…[13] We also did not determine any differences between genders regarding the allergen agents except TP which was more common in females. Khazaei et al [14] reported that smoking did not affect the SPT reactivity to pollen and weeds aeroallergens. Since most of our patients were non-smoker we could not analyze the effects of smoking on SPT results.…”

Section: Discussionmentioning

confidence: 99%

Skin prick test results in patients with chronic allergic rhinitis: Housewives are risky occupational group for the development of allergic rhinitis due to house dust mites

Özdemir

Kasapoğlu

Türkkanı

et al. 2019

Journal of Contemporary Medicine

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Introduction: Allergic Rhinitis (AR) is a common disorder that negatively effects the quality of life with symptoms due to the inflammation of nasal epithelium. Objective of this study is to determine the general demographical and clinical features of patients with AR, who had positive skin prick test (SPT) results. Methods: Patients diagnosed as AR with positive SPT results were analyzed. The allergens tested were: grasses, cereals+grasses, trees 1 (early flowering), trees 2 (late flowering), house-dust mites (Dermatophagoides pteronyssinus (DP), Dermatophagoides farinae (DF), tyrophagus putrescentiae (TP), lepidoglyphus destructor (LD) and acarus siro (AS). Results: Of the total 202 patients, 145 female (with a mean age of 32.42±12.81 years) and 57 male (with a mean age of 28.44±11.5 years) were included in the study. The most common allergens determined were; DF, DP, cereals+grasses and grasses. Tyrophagus significantly was more common in females (p=0.04). Nasal discharge, dyspnea, itching and weakness-tiredness were reported to be more common in females compared with males. DF, DP, TP and LD were statistically significantly more common in housewives (p<0.05). Dyspnea, wheezing and itching were statistically significantly more common in housewives (p<0.05). Discussion and Conclusion: Housewives are risky occupational group for the development of allergic rhinitis due to house dust mites.

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“…After performing skin prick testing in tobacco smoke exposure and nonexposure allergic rhinitis patients, we found that only cockroach ( Periplaneta americana ) antigen from a panel of eight aeroallergens yielded higher rates of positivity, whereas the other seven aeroallergens showed no statistically significant differences. Many reports have shown that tobacco smoke increased allergen sensitization among allergic rhinitis patients [ 31 – 33 ]. However, some reports have shown an inverse effect of tobacco smoke on sensitization [ 29 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…We recruited eligible participants from February 1, 2018, to March 31, 2019, at an out-patient department at Walailak University Hospital, Nakhon Si Thammarat, Thailand. By calculation, we used the formula for study the difference between 2 independent variables for numerical data as follows [ 36 ]:

where n = sample size for each group, p 1 = proportion part 1 (prevalence of aeroallergen sensitization in the tobacco exposure group with allergic rhinitis = 0.67 (house dust mite) [ 37 ], and p 2 = proportion part 2 (prevalence of aeroallergen sensitization in nontobacco exposure group with allergic rhinitis = 0.37 (house dust mite) [ 37 ]. P = ( p 1 + p 2) / 2 = (0.67 + 0.37) / 2 = 0.52, Z α /2 α = 0.05 (two-tailed) = 1.96, and Z β β = 0.1 (one-tailed) = 1.28…”

Section: Methodsmentioning

confidence: 99%

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“Effects of Tobacco Smoke on Aeroallergen Sensitization and Clinical Severity among University Students and Staff with Allergic Rhinitis”

Songnuy

Scholand

Panprayoon

2020

Journal of Environmental and Public Health

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Allergic diseases, affecting a variety of organs, have continuously increased both in developed and developing countries. Tobacco smoke exposure increases prevalence of allergic rhinitis (AR) and may affect allergic sensitization. This study was designed to compare indoor-aeroallergen sensitization between those not exposed and exposed to tobacco smoke in university students and staff with allergic rhinitis. A cross-sectional descriptive study among university students and staff with allergic rhinitis was performed from February 1, 2018, to March 31, 2019. Questionnaires regarding demography, clinical symptoms, and tobacco smoke exposure were implemented. A current smoker was defined as using, at least, 1 cigarette per day for, at least, 1 month. A secondhand smoker was defined as the one who never smoked, but lived with a current smoker, at least, for 1 month. A skin prick test for eight common indoor aeroallergens, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Periplaneta americana, cat dander, dog dander, para grass, careless weed, and Cladosporium spp., was performed. Sensitization was defined as positivity to, at least, 1 aeroallergen. One hundred and twenty-eight adult patients were eligible participants for the study, and 68 cases (53.10%) were classified as having tobacco smoke exposure. Among these, most of them were secondhand smokers (50 cases, 73.50%). There was no statistically significant difference between exposure and nonexposure to tobacco smoke and indoor aeroallergen sensitization, except for the Periplaneta americana antigen (p=0.013). Most of those in the nonexposure group (34 cases, 56.70%) were classified as having intermittent allergic rhinitis, whereas the tobacco exposure group had significantly more prevalence of severe clinical symptoms. In conclusion, tobacco smoke exposure did not appear to have much influence on aeroallergen sensitization for 7 of the 8 antigens examined. However, for the Periplaneta americana antigen, there was a highly significant correlation with patients experiencing worsened allergic rhinitis symptoms. Overall, it was observed that allergic rhinitis patients exposed to tobacco smoke had more severe clinical symptoms. Future studies should look for other potential antigens of interest, such as mould. Implementation of public health practices reducing exposure to tobacco smoke could have benefits in allergic rhinitis patients.

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Cigarette Smoking and Skin Prick Test in Patients With Allergic Rhinitis

Cited by 9 publications

References 20 publications

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Triamcinolone Acetonide versus Fluticasone Propionate in the Treatment of Perennial Allergic Rhinitis: A Randomized, Parallel-Group Trial

Skin prick test results in patients with chronic allergic rhinitis: Housewives are risky occupational group for the development of allergic rhinitis due to house dust mites

“Effects of Tobacco Smoke on Aeroallergen Sensitization and Clinical Severity among University Students and Staff with Allergic Rhinitis”

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