Chrysosporium, A New Causative Agent in Osteomyelitis

Stillwell, William Thomas; Rubin, Benjamin D.; Axelrod, Judith L.

doi:10.1097/00003086-198404000-00032

Cited by 34 publications

(28 citation statements)

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“…The patient's history included a trip to Africa and exposure to dust during home renovations. Histologic sections of the specimen revealed septate hyphae and budding yeasts within and around giant cells (28). The fungus was reported to grow at 37°C and on medium with cycloheximide and to produce numerous arthroconidia initially thought to resemble Geotrichum.…”

Section: Resultsmentioning

confidence: 99%

“…Etymology: hidden (occurrence). Notes: N. obscura was isolated from two successive biopsy samples of a large tibial abscess in the right leg of a 24-year-old African-American male with a 2-month history of osteomyelitis (28). The patient's history included a trip to Africa and exposure to dust during home renovations.…”

Section: Resultsmentioning

confidence: 99%

“…It was identified as a Chrysosporium sp. when it was observed to also produce typical aleurioconidia (28). The patient was treated with amphotericin B over a 4-month period.…”

Section: Resultsmentioning

confidence: 99%

“…Isolates appearing to be morphologically similar to the CANV have also been cultured occasionally from human specimens, and these were included in the analyses to assess their relationships with isolates from reptiles (27,28). Based on a synthesis of the molecular and morphological assessments, six new species in Nannizziopsis and three new species in the new genus Paranannizziopsis are described here.…”

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confidence: 99%

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Molecular Characterization of Reptile Pathogens Currently Known as Members of the Chrysosporium Anamorph of Nannizziopsis vriesii Complex and Relationship with Some Human-Associated Isolates

2013

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In recent years, the Chrysosporium anamorph of Nannizziopsis vriesii (CANV), Chrysosporium guarroi, Chrysosporium ophiodiicola, and Chrysosporium species have been reported as the causes of dermal or deep lesions in reptiles. These infections are contagious and often fatal and affect both captive and wild animals. Forty-nine CANV isolates from reptiles and six isolates from human sources were compared with N. vriesii based on their cultural characteristics and DNA sequence data. Analyses of the sequences of the internal transcribed spacer and small subunit of the nuclear ribosomal gene revealed that the reptile pathogens and human isolates belong in well-supported clades corresponding to three lineages that are distinct from all other taxa within the family Onygenaceae of the order Onygenales. One lineage represents the genus Nannizziopsis and comprises N. vriesii, N. guarroi, and six additional species encompassing isolates from chameleons and geckos, crocodiles, agamid and iguanid lizards, and humans. Two other lineages comprise the genus Ophidiomyces, with the species Ophidiomyces ophiodiicola occurring only in snakes, and Paranannizziopsis gen. nov., with three new species infecting squamates and tuataras. The newly described species are Nannizziopsis dermatitidis, Nannizziopsis crocodili, Nannizziopsis barbata, Nannizziopsis infrequens, Nannizziopsis hominis, Nannizziopsis obscura, Paranannizziopsis australasiensis, Paranannizziopsis californiensis, and Paranannizziopsis crustacea. Chrysosporium longisporum has been reclassified as Paranannizziopsis longispora. N. guarroi causes yellow fungus disease, a common infection in bearded dragons and green iguanas, and O. ophiodiicola is an emerging pathogen of captive and wild snakes. Human-associated species were not recovered from reptiles, and reptile-associated species were recovered only from reptiles, thereby mitigating concerns related to zoonosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…It was identified as a Chrysosporium sp. when it was observed to also produce typical aleurioconidia (28). The patient was treated with amphotericin B over a 4-month period.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Molecular Characterization of Reptile Pathogens Currently Known as Members of the Chrysosporium Anamorph of Nannizziopsis vriesii Complex and Relationship with Some Human-Associated Isolates

2013

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“…At least 5 cases with Chrysosporium as the causative agent have been described in humans where different organs were affected, and bone was involved in 3 of them. [10][11][12][13][14] Among ocular infections, Chrysosporium has been reported to cause keratomycosis, with subsequent perforation in a healthy male. 15 However, a Medline search did not reveal any cases of intraocular infection with Chrysosporium.…”

Section: Discussionmentioning

confidence: 99%