Endogenous Endophthalmitis by<i>Chrysosporium</i>: An Opportunistic Pathogen

Shekhar, Himanshu; Gogia, Varun; Vashisht, Nagendra; Gupta, Shikha; Kakkar, Ashish Kumar; Venkatesh, Pradeep

doi:10.3109/09273948.2013.779726

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…was reported recently to cause invasive pulmonary infection in a 16-yearold male with acute T-cell lymphoblastic leukaemia (Suankratay et al 2015). This species can cause endogenous endophthalmitis and allergic pneumonitis (Shekhar et al 2014;Anstead et al 2012).…”

Section: Discussionmentioning

confidence: 98%

Culture and molecular identification of fungal contaminants in edible bird nests

Chen

Wong

Lim

et al. 2015

Food Additives & Contaminants: Part A

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Widespread food poisoning due to microbial contamination has been a major concern for the food industry, consumers and governing authorities. This study is designed to determine the levels of fungal contamination in edible bird nests (EBNs) using culture and molecular techniques. Raw EBNs were collected from five house farms, and commercial EBNs were purchased from five Chinese traditional medicine shops (companies A-E) in Peninsular Malaysia. The fungal contents in the raw and commercial EBNs, and boiled and unboiled EBNs were determined. Culturable fungi were isolated and identified. In this study, the use of these methods revealed that all EBNs had fungal colony-forming units (CFUs) that exceeded the limit set by Standards and Industrial Research Institute of Malaysia (SIRIM) for yeast and moulds in EBNs. There was a significant difference (p < 0.05) in the number of types of fungi isolated from raw and commercial EBNs, but no significant difference in the reduction of the number of types of fungi after boiling the EBNs (p > 0.05). The types of fungi isolated from the unboiled raw EBNs were mainly soil, plant and environmental fungi, while the types of fungi isolated from the boiled raw EBNs, unboiled and boiled commercial EBNs were mainly environmental fungi. Aspergillus sp., Candida sp., Cladosporium sp., Neurospora sp. and Penicillum sp. were the most common fungi isolated from the unboiled and boiled raw and commercial EBNs. Some of these fungi are mycotoxin producers and cause opportunistic infections in humans. Further studies to determine the mycotoxin levels and methods to prevent or remove these contaminations from EBNs for safe consumption are necessary. The establishment and implementation of stringent regulations for the standards of EBNs should be regularly updated and monitored to improve the quality of the EBNs and consumer safety.

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Section: Discussionmentioning

confidence: 98%

Culture and molecular identification of fungal contaminants in edible bird nests

Chen

Wong

Lim

et al. 2015

Food Additives & Contaminants: Part A

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“…It is a keratinophilic filamentous fungus commonly isolated from soil and occasionally encountered in the laboratory as contaminants of cutaneous and respiratory specimens 1. Although human infection is very rare, it can lead to either serious systemic or ocular diseases 2–4. Among ocular infections, there were only two reports, which were keratomycosis and endophthalmitis from literature search.…”

Section: Discussionmentioning

confidence: 99%

“…Among ocular infections, there were only two reports, which were keratomycosis and endophthalmitis from literature search. Medical failure has been reported, and surgical debridements, penetrating keratoplasty and pars plana vitrectomy were required in both cases 3,4…”

Section: Discussionmentioning

confidence: 99%

“…In the literature review, there were only two case reports on ocular infection. Both cases did not respond to aggressive medical treatment and ended up with surgical interventions 3,4. The authors herein report a first case with severe Chrysosporium keratitis successfully treated with voriconazole.…”

Section: Introductionmentioning

confidence: 87%

“…Although human infection is very rare, it can lead to either serious systemic or ocular diseases 2–4. In the literature review, there were only two case reports on ocular infection.…”

Section: Introductionmentioning

confidence: 99%

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Successful treatment of <em>Chrysosporium</em> keratitis with voriconazole

Thanathanee¹,

Bhoomibunchoo²,

Anutarapongpan³

et al. 2017

IMCRJ

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ObjectiveTo report a patient with severe Chrysosporium keratitis successfully treated by voriconazole.MethodCase report.ResultsA 37-year-old healthy male presented with irritation, pain and reduced vision in his left eye after mud contamination. Examination demonstrated corneal stromal infiltration, endothelial plaque and hypopyon. Corneal scrapings demonstrated numerous septate hyphae, and specimen cultures were positive for Chrysosporium sp. The lesion did not respond to aggressive topical 5% natamycin, 0.15% topical amphotericin B and oral itraconazole. The patient was then treated by topical 1% voriconazole every hour. Intracameral and intrastromal voriconazole injections (50 μg/0.1 mL) were also undertaken. The keratitis was significantly improved after voriconazole.ConclusionTo the best of the authors’ knowledge, this is the first report on the use of voriconazole for Chrysosporium keratitis. Voriconazole may be an effective alternative to conventional antifungal agents in some cases of fungal keratitis. It should be considered before shifting to therapeutic keratoplasty.

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Isolation and Characterization of an Unknown Chrysosporium sp. Producing Subcutaneous Mycosis in an Immunocompromised Patient

et al. 2015

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We report a case of subcutaneous fungal abscess over the great toe caused by a keratinophilic fungus, an unknown Chrysosporium sp., in a 60-year-old diabetic female who was treated successfully with oral fluconazole. The fungus was isolated from aspirated pus, and septate hyphae were seen in fine needle aspiration cytology. Ovoid- to club-shaped hyaline one-celled conidia (aleuriconidia) with broad truncated bases were seen, and sequencing of ITS1-5.8S-ITS2 rDNA revealed belonging to the order Onygenales and most closely related to Chrysosporium spp. isolated from a fowl. Of the 65 species within the genus Chrysosporium, very few have been reported as pathogenic.

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Endogenous Endophthalmitis byChrysosporium: An Opportunistic Pathogen

Cited by 6 publications

References 10 publications

Culture and molecular identification of fungal contaminants in edible bird nests

Culture and molecular identification of fungal contaminants in edible bird nests

Successful treatment of <em>Chrysosporium</em> keratitis with voriconazole

Isolation and Characterization of an Unknown Chrysosporium sp. Producing Subcutaneous Mycosis in an Immunocompromised Patient

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