Chronic Urticaria : Expanding the Autoimmune Kaleidoscope

Gera, Vinay; Vd, Tiwari

doi:10.1016/s0377-1237(04)80015-7

Cited by 5 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However it has been observed that the patients with autoimmune CU generally had more severe symptoms than those with idiopathic CU. [ 13 ] Few studies have been done to evaluate the relationship of severity of urticaria with thyroid autoimmunity. A study done by Aamir et al [ 14 ] in 2008 showed that the frequencies of antithyroid antibodies was significantly higher in patients with CU than in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria

Lunge

Borkar²,

Pande³

2015

Indian Dermatol Online J

View full text Add to dashboard Cite

Background:About 25–45% of patients of chronic urticaria (CU) have been stated to have histamine releasing autoantibodies in their blood. The term autoimmune urticaria is increasingly being accepted for this subgroup of patients. Review of the literature suggests high autologous serum skin test (ASST) positivity and presence of antithyroid microsomal antibodies in patients with autoimmune urticaria.Aims:To study prevalence of ASST positivity and antithyroid microsomal antibodies in chronic “idiopathic” urticaria and to study the correlation between the two parameters.Methods:All patients of chronic idiopathic urticaria satisfying inclusion/exclusion criteria were enrolled in the study after written informed consent. Patients of CU secondary to infections and infestations, physical urticaria including dermatographism, mastocytosis, urticarial vasculitis and those on treatment with immunosuppressive drugs for urticaria were excluded from the study. In all of these patients, complete blood count; ASST, serum T3/T4/thyroid stimulating hormone levels, antithyroid microsomal antibody (AMA) levels were done. Statistical analysis was done by Chi-square test, Fisher exact test and Kappa statistics.Results:Study included 24 males and 26 females with mean age of 39.54 years. Majority of patients belonged to 20–40 years of age. Females showed more ASST positivity. A total of 12 out of 50 (24%) patients showed positive ASST. A total of four out of 12 (33.33%) had positive ASST and raised AMA levels.Conclusion:Only 25% of patients of chronic idiopathic urticaria had positive ASST. ASST and AMA levels were positively correlated in our study. Further studies are required to authenticate this association.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria

Lunge

Borkar²,

Pande³

2015

Indian Dermatol Online J

View full text Add to dashboard Cite

show abstract

“…It has recently been accepted that autoimmunity plays a critical role in its pathogenesis in some of these patients. [ 18 19 ] A few other offenders are listed as under:…”

Section: Etiologymentioning

confidence: 99%

“…This possibility of an autoimmune basis to chronic idiopathic urticaria (CIU) is now widely explored. [ 7 ] This review attempts to discuss the evidence-based pathogenesis and treatment options available, for CU.…”

Section: Introductionmentioning

confidence: 99%

Chronic urticaria

et al. 2011

View full text Add to dashboard Cite

Chronic urticaria (CU) is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ‘idiopathic’ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

show abstract

“…3,4 Most of the recent advances in our understanding of its pathogenesis include the finding of autoantibodies to mast cell receptors in nearly half of patients. 5 But there are no recent studies a large sample of patients dealing with dental infections in urticaria, the aim of our study was to determine the prevalence of dental infection occurring in chronic urticaria patients attending DVL OPD at Osmania General Hospital, Hyderabad.…”

Section: Introductionmentioning

confidence: 99%

A cross sectional study on dental infections in chronic urticaria

et al. 2020

View full text Add to dashboard Cite

Background: Urticaria is considered to be caused by infections, emotions, and also allergy to common substances in the environment, particularly drugs. The relation of active dental infection to chronic urticaria is sought frequently, yet there are few detailed reports of the incidence and importance of such a relationship. The aim of the study was to determine the prevalence of dental infection occurring in chronic urticaria patients attending Dermatology, Venerealogy and Leprosy (DVL) OPD at Osmania General Hospital, Hyderabad. Methods: A cross-sectional study was done from August 2018 to May 2019 on 100 patients of age group between 16 to 60 years with chronic urticaria attending DVL OPD at Osmania General Hospital, Hyderabad. They have been referred to the dental department and were reviewed to determine the incidence of dental infections. Results: Out of 100 cases, 66 were males and 34 were females. Youngest patient seen was 17 years and the oldest was 60 years. Peak incidence was seen in 31 to 40 years (36 cases of 36%), followed by 21 to 30 years (30 cases of 30%), 41 to 50 years (16 cases of 16%), 51 to 60 years (14 case of 14%) and 16 to 20 years (4 cases of 4%). Evidence of dental infections was found in 42 cases of which 26 cases (18 males, 8 females) were having dental caries, 58 (58%) patients had no evidence of dental infection. Conclusions: Urticaria may be considered to be a pattern of reaction to many different stimuli, as suggested by unpredictable remissions and exacerbations. Many of the dental infections go unnoticed in chronic urticaria, we have found a high prevalence (42%) of these infections in our study.

show abstract

Chronic Urticaria : Expanding the Autoimmune Kaleidoscope

Cited by 5 publications

References 26 publications

Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria

Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria

Chronic urticaria

A cross sectional study on dental infections in chronic urticaria

Contact Info

Product

Resources

About