Chronic urticaria

Sachdeva, Sandeep; Gupta, Vivek; Amin, Syed Suhail; Tahseen, Mohd

doi:10.4103/0019-5154.91817

Cited by 44 publications

(37 citation statements)

References 40 publications

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“…An overall average lifelong prevalence of chronic urticaria is estimated to be about 1-2%. Urticaria can be highly distressing and can cause personal, social and occupational disability [1][2][3][4].…”

Section: Results (Tabl I)mentioning

confidence: 99%

“…Sixteen patients gave a positive drug history including non-steroidal anti-inflammatory drugs [9], anti-tubercular treatment [1], anti-depressants [5], Unani medicines [1], and benzathine penicillin [1]. Exacerbating factors included dust [2] and egg [1]. Associated diseases were lichen planus, hepatitis, sinusitis, vitiligo and rheumatic heart disease.…”

Section: Results (Tabl I)mentioning

confidence: 99%

“…Pathophysiologically it is characterized by local vasodilatation and increased permeability of capillaries and small venules followed by transudation of plasma constituents into the papillary and upper reticular dermis. A large number of substances including kinins, prostaglandins, leukotrienes, proteolytic enzymes and the best-known histamine have been found to elicit the typical weal and flare reactions [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Role of Leukotriene receptor antagonist Montelukast in the treatment of chronic urticaria: A hospital based study

Hassan¹,

Bhatt²,

Altaf³

et al. 2012

Our Dermatol Online

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Introduction: Chronic urticaria is a disabling disease which may be refractory to standard therapies. Leukotriene receptor antagonists like montelukast have been tried in allergic diseases like asthma and find mention as a therapeutic option in chronic urticaria. Purposes: A randomized single-blinded non-placebo controlled study to evaluate the role of montelukast, in addition to the adjunctive role of non-sedating antihistamine levocetirizine (H1), was conducted in patients with chronic urticaria. Methods: Thirty-five patients with chronic urticaria were enrolled. Medication was given for a period of twelve weeks. Montelukast 10mg/ day in an adult and 5mg in the age group 6-13 years, 4mg 2-6 years and levocetirizine 5mg once a day was added, if patient had new weals while on therapy. The improvement was monitored by estimating the episodes of wheals and pruritus in any two weeks period. Results: Twenty-two patients showed a good response with occasional wheals at the end of 2 weeks and no weals at the end of 12 weeks. These included all 8 patients on non-steroidal anti-inflammatory drugs (NSAIDS). Four of these patients relapsed on discontinuation of therapy. Conclusions: Montelukast is effective in chronic refractory urticaria especially in patients on non-steroidal anti-inflammatory drugs with occasional add-on use of a non-sedating anti-histamine.

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Section: Results (Tabl I)mentioning

confidence: 99%

Section: Results (Tabl I)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Leukotriene receptor antagonist Montelukast in the treatment of chronic urticaria: A hospital based study

Hassan¹,

Bhatt²,

Altaf³

et al. 2012

Our Dermatol Online

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“…Although frequently benign, it may sometimes be a red flag sign of serious internal disease [9]. Most cases occur at ages 20-40 years, the working age group [10].…”

Section: Introductionmentioning

confidence: 99%

Fascinating Giardia Lamblia and Vexing Chronic Spontaneous Urticaria: An Under-appreciated Association

Siddiqui¹,

Khan²

2016

J Allergy Ther

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Background: Chronic Spontaneous Urticaria (CSU) has been found to have a negative impact on all aspects of patients' lives -physical, mental, social and emotional. The ubiquitous and fascinating Giardia lamblia is primarily a gastrointestinal pathogen but it may present atypically (with or without gastroenterological manifestations). A link between Giardiasis and CSU was identified in the past. However, the possibility of this combination has been underappreciated in clinical practice, even in developed world, resulting in inordinate delay in reaching correct diagnosis and instituting targeted pharmacotherapy. Such a situation adds to the miseries of the patients, both mental anguish and physical suffering.

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“…It affects women more often than men and usual onset is between 20 and 40 years of age [1][2][3]. Its etiology often remains unestablished despite extensive investigative workup rendering causespecific management difficult.…”

mentioning

confidence: 99%

Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical <b><i>Helicobacter pylori</i></b> Infection: A Cross-Sectional Study of 150 Patients

Kohli¹,

Mahajan²,

Rana³

et al. 2018

Int Arch Allergy Immunol

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Background: The Helicobacter pylori infection is linked to chronic urticaria in nearly 60% of patients. We studied clinicoepidemiologic features in patients with chronic urticaria with and without H. pylori infection. Methods: Endoscopic antral biopsy for the rapid urease test (RUT) and histopathology, and serum IgG ELISA for H. pylori infection were performed in 150 patients (male:female ratio 1:2.4) of chronic urticaria aged 18-68 years. Clinicoepidemiologic features including age, gender, age of onset and duration, frequency and distribution of wheals, urticaria severity score, and systemic symptoms were analyzed in patients with and without H. pylori. The results of serum IgG ELISA for H. pylori were compared with 106 age- and gender-matched healthy adult controls. Results: The RUT in 84 patients (56%), histopathology in 76 patients (50.6%), and H. pylori IgG ELISA in 94 patients (62.6%) were positive. H. pylori IgG ELISA was positive only in 35 (33%) controls, suggesting that chronic urticaria patients were more likely to have asymptomatic H. pylori infection than normal controls. Although not statistically significant, patients with H. pylori had a higher mean urticaria severity score, number of urticaria/angioedema episodes per year, and involvement of more body sites, particularly the scalp, palms, and soles. The constitutional or gastrointestinal symptoms were statistically higher in patients with H. pylori infection than those without it. Conclusion: A subset of chronic urticaria patients appears to have asymptomatic H. pylori infection. However, its implications in chronicity, recurrences, the severity of urticaria, other systemic manifestations, and management remains conjectural in view of 33% of controls also having positive H. pylori ELISA and the endemicity of infection in developing countries.

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Chronic urticaria

Cited by 44 publications

References 40 publications

Role of Leukotriene receptor antagonist Montelukast in the treatment of chronic urticaria: A hospital based study

Role of Leukotriene receptor antagonist Montelukast in the treatment of chronic urticaria: A hospital based study

Fascinating Giardia Lamblia and Vexing Chronic Spontaneous Urticaria: An Under-appreciated Association

Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical <b><i>Helicobacter pylori</i></b> Infection: A Cross-Sectional Study of 150 Patients

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