Chronic periaortitis and HLA–DRB1*03: Another clue to an autoimmune origin

Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

“…An association between chronic periaortitis and HLA-DRB1*03, an allele linked to several autoimmune conditions, was recently noted (42). This might explain the simultaneous occurrence of autoimmune disorders (e.g., lupus erythematosus, Wegener's granulomatotis, polymyalgia rheumatica) in some patients with chronic periaortitis (9,10,16) and the often observed beneficial response to immunosuppressive treatment (13).…”

Retroperitoneal Fibrosis Secondary to Different Etiologies (Hemilaminectomy and Hypothyroidism): Reports of Two Cases

“…However, the high frequency of the existence of HLA-DRB1*03 allele in patients gives an idea about the genetic predisposition of the disease as it is also commonly seen in type 1 diabetes mellitus, myasthenia gravis, and systemic lupus erythematosus. [22,23] The similarities to systemic large-vessel vasculitides in some patients with idiopathic retroperitoneal fibrosis support the systemic disease idea. [24] The vascular inflammatory process involves abdominal aorta, common iliac arteries, and the thoracic aorta and its branches, as it is in giant-cell arteritis and Takayasu's arteritis.…”

Fibrose rétropéritonéale : revue de littérature

“…Des études génétiques ont montré une forte association entre FRPI et HLA-DRB1*03, allèle lié à de nombreuses MAI telles que le diabète de type 1, la myasthénie grave et la thyroïdite autoimmune. 16 Le polymorphisme du gène de CCR5 expose à un risque accru de présenter une FRPI, surtout dans sa forme anévrysmale.…”