Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

Bommel, E. F. H. van; Tits, L.J.H. van; Berg, Elisabeth; Prins, J. A.; Stalenhoef, Anton F. H.

doi:10.1007/s00296-009-1288-6

Cited by 9 publications

(4 citation statements)

References 42 publications

(69 reference statements)

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“…It might be worth noting that elderly males are most frequently affected by IRF, as with IgG4-related disease and atherosclerosis. This has led to the hypothesis originally formulated by Mitchinson and Parums [12,13] that an inflammatory stimulus deriving from atherosclerotic plaques, which are associated with ageing and more frequent in men, would lead in predisposed individuals to an autoimmune reaction to plaque-related antigens eventually followed by fibrosis [14]. These aspects will be expanded upon in the paragraph regarding the pathogenesis of IRF.…”

Section: E P I D E M I O L O G Ymentioning

confidence: 96%

Idiopathic retroperitoneal fibrosis: an update for nephrologists

Raglianti

Rossi

Vaglio

2020

Nephrology Dialysis Transplantation

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Idiopathic retroperitoneal fibrosis (IRF) is a rare condition characterized by the development of a peri-aortic and peri-iliac tissue showing chronic inflammatory infiltrates and pronounced fibrosis. Ureteral entrapment with consequent obstructive uropathy is one of the most common complications of IRF, which can lead to acute renal failure and, in the long term, to varying degrees of chronic kidney disease. IRF may be isolated or develop in association with autoimmune diseases (e.g. Hashimoto’s thyroiditis and psoriasis) and other fibro-inflammatory disorders (often within the spectrum of immunoglobulin G4-related disease), which suggests that it should be considered as a potentially systemic condition. IRF is an immune-mediated disease: genetic variants (e.g. human leukocyte antigen (HLA)-DRB1*03) and environmental agents (mainly exposure to asbestos and smoking) are strongly associated with an increased risk of developing the disease, while a complex network of chemokines (e.g. CXCL12 and C-C moti chemokine 11 (CCL11)) and cytokines [e.g. interleukin (IL)-6, IL-12 and IL-13] is likely to orchestrate the inflammatory response and simultaneously promote fibrosis. Glucocorticoids, alone or in combination with traditional immunosuppressants such as methotrexate and mycophenolate mofetil, are usually efficacious and promptly induce disease remission; however, up to 50% of patients relapse, thus requiring repeat immunosuppressive courses. Biologic drugs, namely rituximab, are being explored for the treatment of IRF. In addition to medical therapies, interventional procedures (mainly ureteral stenting) are required to relieve ureteral obstruction, whereas surgical ureterolysis is generally reserved to refractory cases. If appropriately treated, then the overall and renal prognosis of IRF are good, with <5% patients developing end-stage renal disease.

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Section: E P I D E M I O L O G Ymentioning

confidence: 96%

Idiopathic retroperitoneal fibrosis: an update for nephrologists

Raglianti

Rossi

Vaglio

2020

Nephrology Dialysis Transplantation

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“…Also, chronic periaortitis may affect patients without atherosclerosis, and it has been reported in pediatric patients (Miller et al, 2003). A recent study showed no significant differences in anti-ox-LDL antibody levels between patients with chronic periaortitis and controls (van Bommel et al, 2011). Furthermore, a number of findings support the hypothesis that chronic periaortitis may be a manifestation of systemic disease rather than the result of a local reaction.…”

Section: Pathogenesismentioning

confidence: 82%

Chronic Periaortitis as a Systemic Autoimmune Disease

Suh¹

2011

Autoimmune Disorders - Pathogenetic Aspects

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“…In a recent study, van Bommel et al [32 ]showed no significant difference between patients with stable chronic periaortitis and control subjects with regard to oxLDL Ab titers. Our study population consisted of patients with AA dilatation due to AR or hypertension, and none of the patients had AAA.…”

Section: Discussionmentioning

confidence: 98%

Autoantibodies to Oxidized Low-Density Lipoprotein in Patients with Aortic Regurgitation: Association with Aortic Diameter Size

Shimoni¹,

Bar²,

Zilberman³

et al. 2014

Cardiology

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Background: Aortic regurgitation (AR) is a condition associated with volume overload, causing left-ventricular (LV) remodeling, eccentric LV hypertrophy and eventually heart failure. LV remodeling associated with AR is regulated by mechanical stress, neurohormonal activation, inflammation and oxidative stress. Since anti-oxidized low-density lipoprotein (LDL) antibodies (Abs) are a measurable marker of oxidative stress, we hypothesized that an increased level of circulating oxidized LDL (oxLDL) Abs may be related to remodeling of the left ventricle in patients with significant AR. Methods: We assessed IgG anti-oxLDL Abs in 31 patients with significant AR and compared them to 30 patients with similar risk factors and no valvular disease. Abs to oxLDL were determined by ELISA. Results: The 2 groups had similar clinical characteristics. There was no difference between patients with AR and patients with no AR in the level of anti-oxLDL Abs. However, in all patients and controls, anti-oxLDL Abs correlated positively with the diameter of the ascending aorta (AA; r = 0.32, p = 0.016) and the level of oxLDL Abs was significantly higher in patients with an AA diameter ≥39 mm. On multivariate analysis, only white blood cell count and AA diameter were related to anti-oxLDL Abs in all patients. Conclusions: We did not find a difference in the level of anti-oxLDL Abs between patients with AR and controls; however, there was a strong correlation between anti-oxLDL Abs and AA diameter.

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Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

Cited by 9 publications

References 42 publications

Idiopathic retroperitoneal fibrosis: an update for nephrologists

Idiopathic retroperitoneal fibrosis: an update for nephrologists

Chronic Periaortitis as a Systemic Autoimmune Disease

Autoantibodies to Oxidized Low-Density Lipoprotein in Patients with Aortic Regurgitation: Association with Aortic Diameter Size

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