Chronic necrotizing pulmonary aspergillosis with concomitant aspergilluria

Lopes, Jorge O.; Oliveira, L. T. O.; Pinto, Maximiliano Soares; Klock, Clóvis

doi:10.1111/j.1439-0507.1997.tb00216.x

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Still, positive cultures are highly predictive of an underlying disease caused by Aspergillus and can be attempted from BAL fluid, sputum, biopsy or drainage fluid . Isolation of Aspergillus cultures from urine has been reported in one case of advanced and lethal CNPA …”

Section: Diagnosismentioning

confidence: 99%

“…33 Isolation of Aspergillus cultures from urine has been reported in one case of advanced and lethal CNPA. 71 Whenever feasible a biopsy of suspicious radiologic lesions should be performed as many fungal infections are missed by respiratory and serological sampling alone and information on the retrieved species and resistance pattern might be incomplete. 72 Histology of CPA varies depending on underlying illness and may include inflammation, caseous material and fungal hyphae.…”

Section: Mycological Evidencementioning

confidence: 99%

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Chronic pulmonary aspergillosis

Schweer,

Bangard,

Hekmat

et al. 2013

Mycoses

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Summary Chronic pulmonary aspergillosis (CPA) is a group of consuming diseases usually presenting with prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may occasionally occur. CPA affects patients with underlying pulmonary conditions, for example, chronic obstructive pulmonary disease or mycobacteriosis or common immunosuppressive conditions such as diabetes. Precise epidemiology is unknown, and while prevalence is considered low the chronic and relapsing nature of the disease challenges the treating physician. Diagnostics largely rely on serologic Aspergillus precipitins and findings on thoracic computed tomography. The latter are manifold comprising cavity formation, pleural involvement and sometimes aspergilloma. Other markers for aspergillosis are less helpful, in part due to the non‐ or semi‐invasive nature of these forms of Aspergillus infection. Various antifungals were shown to be effective in CPA treatment. Azoles are the most frequently applied antifungals in the outpatient setting, but are now compromised by findings of Aspergillus resistance. Long‐term prognosis is not fully elucidated and may be driven by the underlying morbidities. Prospective registry‐type studies may be suitable to systematically broaden our CPA knowledge base. This article gives an overview of the available literature and proposes a clinical working algorithm for CPA management.

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Section: Diagnosismentioning

confidence: 99%

Section: Mycological Evidencementioning

confidence: 99%

Chronic pulmonary aspergillosis

Schweer,

Bangard,

Hekmat

et al. 2013

Mycoses

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Fungurie nei pazienti ospedalizzati: indagine retrospettiva multicentrica

Faggi¹,

Farina²,

Manso³

et al. 2004

Microbiol Med

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INTRODUZIONE E SCOPODELLA RICERCA L'isolamento di funghi dalle urine è un evento infrequente nella popolazione generale sia adulta che pediatrica (3) mentre numerose sono le segnalazioni nella popolazione ospedalizzata, in particolare in quella ricoverata in reparti di Terapia Intensiva (7,10,18). Lieviti appartenenti al genere Candida sono quelli più frequentemente ritrovati; saltuariamente sono stati isolati altri lieviti (Trichosporon, Cryptococcus, Saccharomyces ecc), eccezionalmente funghi filamentosi (Aspergillus, Fusarium) (9, 12, 16). L'interpretazione da dare all'isolamento di miceti dalle urine è non facile, in particolare per quello di lieviti appartenenti al genere Candida. Il loro isolamento, infatti, potrebbe essere dovuto ad una contaminazione da parte della flora microbica perineale, ad una colonizzazione transitoria del distretto urinario o ad una vera e propria infezione conseguente o meno ad una candidemia. Lo scopo dell'indagine che il Comitato Studio Micologia (CoSM) dell'AMCLI ha proposto, è stato quello di valutare, con un'indagine retrospettiva multicentrica sulle fungurie in ambiente ospedaliero, gli aspetti epidemiologici di tale condizione in relazione alle batteriurie ed alle fungemie. MATERIALI E METODIL'indagine è stata condotta in sei centri ospedalieri italiani (Bergamo, Novara, Varese, Firenze, Ancona, Pescara) nel periodo 1 gennaio 2001 -31 dicembre 2002. Sono stati valutati retrospettivamente, a partire dai dati degli archivi informatici dei laboratori di Microbiologia, i risultati di 101024 urinocolture provenienti da pazienti ricoverati in reparti di Terapia Intensiva, in reparti chirurgici ed in repar-

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Chronic necrotizing pulmonary aspergillosis with concomitant aspergilluria

Abstract: This paper reports a case of chronic necrotizing pulmonary aspergillosis in a patient without underlying disease. Aspergilluria was the starting point in the search for the origin of the pulmonary disease, later confirmed by an open lung biopsy.

Cited by 2 publications

References 9 publications

Chronic pulmonary aspergillosis

Chronic pulmonary aspergillosis

Fungurie nei pazienti ospedalizzati: indagine retrospettiva multicentrica

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