Chronic mild stress impairs cognition in mice: From brain homeostasis to behavior

Li, Song; Wang, Che Chuan; Wang, Wei; Dong, Huiping; Hou, Peng; Tang, Yi‐Yuan

doi:10.1016/j.lfs.2008.02.010

Cited by 134 publications

(107 citation statements)

References 65 publications

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“…Alternatively, and considering that physical and psychological stress lead to a decrease in hippocampal cell proliferation and neurogenesis [51][52][53], rewarded running may pose a 'stressful' situation, in which running is no more performed on a strictly voluntary basis.…”

Section: Running For a Rewardmentioning

confidence: 99%

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

Klaus

Hauser

Slomianka

et al. 2009

Behavioural Brain Research

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A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice Klaus, F; Hauser, T; Slomianka, L; Amrein, I; Lipp, H P Klaus, F; Hauser, T; Slomianka, L; Amrein, I; Lipp, H P (2009). A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice. A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice Abstract Exercise is one of the best-known stimulators of adult hippocampal neurogenesis, but it is not known if voluntary changes in the intensity of exercise are accompanied by changes in neurogenesis. In this study we investigated whether a reward influences the performance in a running wheel and the rate of cell proliferation, neuronal differentiation and cell death in C57BL/6 mice. Mice had free access to a running wheel during the first week of the experiment. In the second week, animals were rewarded for their performance and compared to normal voluntary running and control mice. A reward significantly increased the performance by 78% when compared to the non-rewarded performance of the first week.The performance of the non-rewarded runners remained relatively constant. Fourteen days of exercise significantly increased cell proliferation by 27% and the number of doublecortin immunoreactive cells by 46%. A reward and the associated increase of performance did not modulate proliferation, cell death or the number of cells entering the neuronal lineage. We suggest that, in C57BL/6 mice, either exercise increases adult hippocampal neurogenesis to a ceiling value, which is reached by a performance at or below the level achieved by voluntary wheel running, or that a possible positive effect of increased running-wheel activity is balanced by stress resulting from rewarded running, which is no longer performed on a strictly voluntary basis. We suggest that, in C57BL/6 mice, either exercise increases adult hippocampal neurogenesis to a ceiling value, which is reached by a performance at or below the level achieved by voluntary wheel running, or that a possible positive effect of increased is balanced by stress resulting from rewarded running, which is no longer performed on a strictly voluntary basis.

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Section: Running For a Rewardmentioning

confidence: 99%

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

Klaus

Hauser

Slomianka

et al. 2009

Behavioural Brain Research

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“…According to the literature, stress can improve, destroy or have no effect on learning and memory (1,2). These contradictory results can be explained by different variables, including the nature, duration and harrowing extent of the stressor, the extent and nature of the task and subject characteristics such as age and gender (3).…”

Section: Introductionmentioning

confidence: 99%

“…However, in most research, voluntary exercise was used (1,8). It should be noted that the effects differ (9).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Darkhah

Zarghami

Bushehri

et al. 2016

Jentashapir J Health Res

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“…The pleiotropic actions of IL-6 as both a proand an antiinflammatory cytokine are manifest via transsignaling and classical pathways, respectively (41). Chronic mild stress, which impairs memory in rats, stimulates the production of proinflammatory cytokines, including IL-6, TNF-α, and IL-1β (42). Similar to chronic stress in rats, psychosocial stress in humans impairs cognitive function and is related to several mood disorders (42).…”

Section: Discussionmentioning

confidence: 99%

Comparison of hippocampal interleukin-6 immunoreactivity after exhaustive exercise in both exercise-trained and untrained rats

Aral¹,

Pınar²,

Göktaş³

et al. 2014

Turk J Med Sci

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Chronic mild stress impairs cognition in mice: From brain homeostasis to behavior

Cited by 134 publications

References 65 publications

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

The Effect of Exercise on Learning and Spatial Memory Following Stress-Induced Sleep Deprivation (Sleep REM) in Rats

Comparison of hippocampal interleukin-6 immunoreactivity after exhaustive exercise in both exercise-trained and untrained rats

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