Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer

Khansari, Nemat; Shakiba, Yadollah; Mahmoudi, Mahdi

doi:10.2174/187221309787158371

Cited by 755 publications

(567 citation statements)

References 87 publications

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“…However, excessive ROS bring about oxidative stress that cause injury to various cellular constituents such as lipid, protein and DNA, leading to the alteration in the integrity of cell membrane that consequently result in growth arrest, senescence or apoptosis [3] . They have been reported to play a major role in the pathogenesis of various human diseases including ischemia, carcinogenesis, inflammation/immune injury, arthritis, coronary diseases, hemorrhagic shock, cataract as well as age-related degenerative brain disorders [4,5] . Oxidative stress is thought to affect many intracellular compartments in particular the mitochondria.…”

Section: Introductionmentioning

confidence: 99%

African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

Elekofehinti

Kamdem

Bolingon

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

Elekofehinti

Kamdem

Bolingon

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…Oxidative stress and inflammation often occur together and some propose that each enhances the formation of each other (Conner and Grisham, 1996;Gill et al, 2010;Khansari et al, 2009;Nathan and Cunningham-Bussel, 2013). Proinflammatory cytokines which had been observed to be elevated after SM exposure Two-way ANOVA with Newman-Keuls post-test corrected for multiple comparisons was performed to determine differences between groups, bars with different letters are significantly different from one another (P < .05).…”

Section: Discussionmentioning

confidence: 99%

From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity

et al. 2016

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Sulfur mustard (bis 2-chloroethyl ethyl sulfide, SM) is a powerful bi-functional vesicating chemical warfare agent. SM tissue injury is partially mediated by the overproduction of reactive oxygen species resulting in oxidative stress. We hypothesized that using a catalytic antioxidant (AEOL 10150) to alleviate oxidative stress and secondary inflammation following exposure to SM would attenuate the toxic effects of SM inhalation. Adult male rats were intubated and exposed to SM (1.4 mg/kg), a dose that produces an LD 50 at approximately 24 h. Rats were randomized and treated via subcutaneous injection with either sterile PBS or AEOL 10150 (5 mg/kg, sc, every 4 h) beginning 1 h post-SM exposure. Rats were euthanized between 6 and 48 h after exposure to SM and survival and markers of injury were determined. Catalytic antioxidant treatment improved survival after SM inhalation in a dose-dependent manner, up to 52% over SM PBS at 48 h post-exposure. This improvement was sustained for at least 72 h after SM exposure when treatments were stopped after 48 h. Non-invasive monitoring throughout the duration of the studies also revealed blood oxygen saturations were improved by 10% and clinical scores were reduced by 57% after SM exposure in the catalytic antioxidant treatment group. Tissue analysis showed catalytic antioxidant therapy was able to decrease airway cast formation by 69% at 48 h post-exposure. To investigate antioxidant induced changes at the peak of injury, several biomarkers of oxidative stress and inflammation were evaluated at 24 h post-exposure. AEOL 10150 attenuated SM-mediated lung lipid oxidation, nitrosative stress and many proinflammatory cytokines. The findings indicate that catalytic antioxidants may be useful medical countermeasure against inhaled SM exposure.Key words: sulfur mustard; chemical weapons; antioxidant.Sulfur mustard (SM) is a chemical warfare agent possessing strong alkylating properties that induces inflammation and tissue necrosis. SM exposure produces delayed and highly incapacitating injuries that can be lethal (Anderson, 2015). SM was used during World War I and is still maintained in the chemical weapons arsenals of several countries (Kehe and Szinicz, 2005). A specific and effective antidote is not available for use after SM exposure despite research conducted for nearly 100 years (Kehe and Szinicz, 2005). The population most at risk for exposure to SM is comprised of soldiers and individuals working or living near storage depots, but SM is also considered to be a potential terrorist threat due to its low cost of production and simple synthesis.Sulfur mustard (SM) vapor adversely affects the skin, eyes, and the respiratory tract. The respiratory tract is highly

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“…2) [16,112]. These proinflammatory cytokines secreted by the cells of the innate immune response are able in turn also to induce the production of free radicals.…”

Section: Innate Immunosenescence and Age-associated Pathologiesmentioning

confidence: 99%

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Fülöp

Fortin²,

Lesur³

et al. 2012

TOLSJ

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Abstract:The immune system plays an important role in the defence against various threats to health, such as pathogens, cancer cells or modified-self proteins. With aging there is a decrease in the immune response, called immunosenescence, concomitantly with the increase in some age-related diseases such as infections, autoimmune disorders, chronic inflammatory diseases and cancer. The immune response is traditionally divided between innate and adaptive immune responses. Accumulating evidence suggests that immunosenescence is not only restricted to the adaptive but also affects the innate immune system. Assessment of innate immune system functions revealed that it is also susceptible to age-related dysregulation. Furthermore, it is becoming clear that the sustained function of innate cells is indispensable for the adequate functioning of the adaptive immune response. This review will describe the changes in the innate immune response with aging and the recent discoveries, which may shed new light on its contribution to immunosenescence.

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Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer

Cited by 755 publications

References 87 publications

African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity

The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

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