African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

Elekofehinti, Olusola Olalekan; Kamdem, Jean Paul; Bolingon, Aline Augusti; Athayde, Margareth Linde; Lopes, Seeger Rodrigo; Waczuk, Emily Pansera; Kade, Ige Joseph; Adanlawo, Isaac Gbadura; Rocha, João Batista Teixeira da

doi:10.1016/s2221-1691(13)60152-5

Cited by 36 publications

(24 citation statements)

References 40 publications

(43 reference statements)

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“…The phytochemical screening of the plant studied in the present study has not been reported previously. The result is well supported as several flavonoids, diterpenes, sterols and phenylpropanoid glycosides have been isolated from C. trichotomum (Kim et al 2001 ; Kato et al 1971 ; Okigawa et al 1970 ; Kawano et al 1967 ), and methanol extract of S. anguivi has been reported to contain phenolic acids such a gallic acid, chlorogenic acid, caffeic acid and the flavonoid contents such as rutin by HPLC fingerprinting (Elekofehinti et al 2013 ).…”

Section: Resultsmentioning

confidence: 79%

“…The antioxidant activity of crude methanolic extract of only P. cablin , B. platyphylla , C. trichotomum and ethanol extract of C. trichotomum were measured as the S. anguivi and D. sinuata did not exhibit free radical scavenging activity when screened with DPPH. Hence, it can be concluded that their traditional uses are not likely to be due to intrinsic free radical scavenging activities although DPPH radical scavenging activity of S. anguivi has been reported to be Elekofehinti et al ( 2013 ). The results of the free radical scavenging activities of the selected plants are summarized in table below (Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Scientific validation of medicinal plants used by Yakkha community of Chanuwa VDC, Dhankuta, Nepal

2016

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Ethnobotanical knowledge is important among tribal people, but much of the information is empirical due to the lack of scientific validation. The purpose of this study was to document the medicinal plants used by an ethnic group (Yakkha) at Chanuwa VDC of Dhankuta district in Nepal and to validate scientifically in the use of plants based on results of phytochemical, antimicrobial and antioxidant property analyses and available literature reports. Data were collected through interviews of the Yakkha people with the help of a semi-structured questionnaire and the guided field walk method. A total of 30 different medicinal plants were recorded along with their vernacular names (for few plants) used by the Yakkha community’s people. Literature review reveals that most of the plant species described herein have also been used in other countries, too. Among 30 plants selected for this study methanol extract of five ethno-medicinal plants viz., Dendrocnide sinuata, Solanum anguivi, Pogostemon cablin, Boehmeria platyphylla and Clerodendrum trichotomum and ethanol extract of C. trichotomum were subjected for antibacterial and antioxidant properties. The antimicrobial activities were measured using the paper disc diffusion method. The antioxidant properties of plants were measured by DPPH and FRAP reduction assay. Among all extracts, ethanol extract of C. trichotomum and methanol extract of B. platyphylla displayed the highest antibacterial and antioxidant activities, respectively.

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Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Scientific validation of medicinal plants used by Yakkha community of Chanuwa VDC, Dhankuta, Nepal

2016

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“…In addition to the high levels of vitamin C and β-carotene, the African eggplant has significant levels of alkaloids, saponins, flavonoids, tannins, ascorbic acid and steroids (Chinedu et al 2011a, b;Neugart et al 2017;Sekulya et al 2018) making it a potential source of precursors for pharmaceutical drugs. There are several reports on the medicinal properties of Solanum anguivi (Ripperger and Himmelreich 1994;Elekofehinti et al 2012Elekofehinti et al , 2013Elekofehinti et al , 2015, confirming its traditional use as medicine in certain parts of Africa. Breadfruit {Artocarpus altilis (Parkinson) Fos-berg} contains fatty acids and extracts that are used in pest management (Jones et al 2012;Eccles et al 2019) and has traditionally been used in Asia for the treatment of malaria, yellow fever, dengue fever (Jacob et al 2015), liver cirrhosis, hypertension and diabetes (Wang and Wang 2010;Jones et al 2012).…”

Section: Medicinal/pharmaceutical/cosmetic Valuementioning

confidence: 94%

Genetics and breeding for climate change in Orphan crops

et al. 2021

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Climate change is rapidly changing how we live, what we eat and produce, the crops we breed and the target traits. Previously underutilized orphan crops that are climate resilient are receiving much attention from the crops research community, as they are often the only crops left in the field after periods of extreme weather conditions. There are several orphan crops with incredible resilience to biotic and abiotic stresses. Some are nutritious, while others provide good sources of biofuel, medicine and other industrial raw materials. Despite these benefits, orphan crops are still lacking in important genetic and genomic resources that could be used to fast track their improvement and make their production profitable. Progress has been made in generating draft genomes of at least 28 orphan crops over the last decade, thanks to the reducing cost of sequencing. The implementation of a structured breeding program that takes advantage of additional modern crop improvement tools such as genomic selection, speed breeding, genome editing, high throughput phenotyping and breeding digitization would make rapid improvement of these orphan crops possible, but would require coordinated research investment. Other production challenges such as lack of adequate germplasm conservation, poor/non-existent seed systems and agricultural extension services, as well as poor marketing channels will also need to be improved if orphan crops were to be profitable. We review the importance of breeding orphan crops under the increasing effects of climate change, highlight existing gaps that need to be addressed and share some lessons to be learned from major crops.

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“…Antioxidant properties and Ca 2? -induced mitochondrial swelling inhibition (Elekofehinti et al 2013) have been previously reported for S. anguivi saponin. Here, we further investigated its in vitro ROS-quenching properties in synaptosomal and mitochondrial fractions of rat brain.…”

Section: Introductionmentioning

confidence: 63%

Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe2+ and sodium nitroprusside in rat brain synaptosome P2 fraction

et al. 2015

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Solanum anguivi fruit saponin has antidiabetic property via interference with cellular energy metabolism and inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidant role of S. anguivi saponin was investigated in the P2 synaptosomal fraction of rat brain. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay, S. anguivi saponin concentration- dependently (10-200 µg/ml) reversed Fe and sodium nitroprusside- induced decrease in mitochondrial activity via inhibition of ROS production, ROS-induced oxidation of protein and non-protein thiol-containing molecules and lipid peroxidation as measured by thiobarbituric acid reactive substances levels. Conclusively, S. anguivi fruit saponin represents a class of natural compounds with the ability to reverse synaptosomal disruption, loss of mitochondrial integrity and function often associated with the progression of Huntington's disease, Alzheimer disease, Parkinson disease and amyotrophic lateral sclerosis diseases.

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African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca2+-induced mitochondrial swelling

Cited by 36 publications

References 40 publications

Scientific validation of medicinal plants used by Yakkha community of Chanuwa VDC, Dhankuta, Nepal

Scientific validation of medicinal plants used by Yakkha community of Chanuwa VDC, Dhankuta, Nepal

Genetics and breeding for climate change in Orphan crops

Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe2+ and sodium nitroprusside in rat brain synaptosome P2 fraction

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