The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Fülöp, Tamás; Fortin, Carl; Lesur, Olivier; Dupuis, Gilles; Kotb, J. R.; Lord, Janet M.; Larbi, Anis

doi:10.2174/1876326x01206010121

Cited by 15 publications

(3 citation statements)

References 111 publications

(178 reference statements)

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“…Our data indicate that this strategy takes advantage of the fully functional inflammasome response to strong NLRP3 agonists like nigericin or ATP by myeloid cells in aged mice. Our study has implications to understanding immunomodulatory strategies that are needed to boost waning immunity in the elderly [20]. Successful application of these strategies will require controlled stimulation of protective immune responses without exacerbating the release of potentially harmful proinflammatory cytokines.…”

Section: Resultsmentioning

confidence: 99%

Defective pro-IL-1β responses in macrophages from aged mice

et al. 2012

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BackgroundCytokines regulated by the inflammasome pathway have been extensively implicated in various age-related immune pathologies. We set out to elucidate the contribution of the nod-like receptor protein 3 (NLRP3) inflammasome pathway to the previously described deficiencies in IL-1β production by macrophages from aged mice. We examined the production of pro-IL-1β and its conversion into IL-1β as two separate steps and compared these cytokine responses in bone marrow derived macrophages from young (6–8 weeks) and aged (18–24 months) C57BL/6 mice.FindingsRelative to macrophages from young mice, macrophages from aged mice produced less pro-IL-1β after TLR4 stimulation with LPS. However upon activation of the NLRP3 inflammasome with ATP, macrophages from young and aged mice were able to efficiently convert and secrete intracellular pro-cytokines as functional cytokines.ConclusionsLower levels of IL-1β production are a result of slower and lower overall production of pro-IL-1β in macrophages from aged mice.

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Section: Resultsmentioning

confidence: 99%

Defective pro-IL-1β responses in macrophages from aged mice

et al. 2012

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“…We will briefly review the changes that are observed at the immunological level with aging and consider their putative causes and consequences for health and survival. Aging affects both arms of the immune system, namely the innate and the adaptive arms of the immune system [13,14]. The most widely studied and understood part is the cellular immunity.…”

Section: The Immune System a System Among Othersmentioning

confidence: 99%

On the Immunological Theory of Aging

Fülöp

Witkowski

Pawelec

et al. 2014

Aging

105

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Aging is a complex phenomenon the cause of which is not fully understood, despite the plethora of theories proposed to explain it. As we age, changes in essentially all physiological functions, including immunity, are apparent. Immune responses decrease with aging, contributing to the increased incidence of different chronic diseases with an inflammatory component (sometimes referred to as 'inflamm-aging'). It is clear from many studies that human longevity may be influenced by these changes in the immune system, but how they proceed is not clearly determined. In this chapter, we will review the age-related changes in the immune response and assess the validity of the immune theory of aging (i.e. that these changes in immune response are the primary cause of aging). Many data in humans support the notion that age-associated immune dysfunction may at least in part explain the aging process. Explanatory power may be enhanced by combination with other theories such as the free radical theory. More longitudinal studies are needed to corroborate the immune theory of aging.

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“…The immune system plays an important role in defending body against various threats to health, such as pathogens, cancer cells or modified-self proteins. The immune response is traditionally divided into innate and adaptive immune responses [10]. Lymphocytes as the primary immune cells are divided into two major groups: B cells and T cells.…”

Section: Biological Immune Systemmentioning

confidence: 99%

A Security Model for Cloud Computing Based on Autonomous Biological Agents

Arabalidousti¹,

Banirostam²

2013

IJCCSA

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Besides many advantages which cloud computing creates, there are different concerns such as security. In this paper, the conceptual model based on Biological Immune System (BIS) will be proposed in order to create security in cloud computing. BIS has several features such as distributed computing, self organizing, self-learning that are considered in distributed environments like clouds. In proposed model, five groups of autonomous agents are used. The structure of agents is based on Biological Agents (BA) that have memory and could use previous experiments. Agents have the ability to learn and interact with each other. Each agent has different functions. Their designs are based on B and T lymphocyte. This model is designed at two levels. In the first level, roles, relationship and activities of each agent are described and their components such as modules, programs and functions are shown in the second level. By using these intelligent autonomous agents, attacks can be identified and intrusion can be prevented. The proposed model is based on collaboration of the agents and doesn't need centralized management.

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The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?

Cited by 15 publications

References 111 publications

Defective pro-IL-1β responses in macrophages from aged mice

Defective pro-IL-1β responses in macrophages from aged mice

On the Immunological Theory of Aging

A Security Model for Cloud Computing Based on Autonomous Biological Agents

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