Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty

Petrovay, Fruzsina; Heltai, Krisztina; Kis, Zoltán; Tresó, Bálint; Gönczöl, Éva; Burián, Katalin; Endrész, Valéria; Vályi‐Nagy, István

doi:10.1007/s00011-007-7045-y

Cited by 11 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of its broad arrhythmogenic potential, and the lack of prospective data on the role of histamine in patients with AF, a pilot study was recently performed to evaluate plasma histamine concentrations in patients with AF: there was a subpopulation of 10 patients with AF (21.2% of the enrolled subjects) that demonstrated clearly elevated levels of histamine [4]. In these patients, increased plasma histamine levels may be the result of ingestion of histamine containing food, allergic or pseudo-allergic reactions, infectious or immunologic disorders or other factors [28].…”

Section: Role Of Histaminementioning

confidence: 99%

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Gammone

Vicentini

Riccioni

et al. 2018

Reports

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common type of arrhythmia: a disorganized electrical atrial activity leading to irregular ventricular beats. Its most common risk factors include high blood pressure, congenital and valvular heart diseases, aging, heart failure and coronary heart diseases. Other risk factors include excessive alcohol intake, tobacco smoking, diabetes mellitus and thyrotoxicosis. However, many cases are not associated with any of these risk factors: probably, in these patients, immunological, functional and even dietary mechanisms may be responsible to induce cardiac arrhythmias. Several studies have focused on immunological and neurohumoral mechanisms; however, little information is available about the potential relationship between dietary patterns and atrial fibrillation episodes. This case report describes a potential correlation between biogenic amines in ingested food and recurrent atrial fibrillation onset in a 61-years old man in absence of a remarkable clinical history and of the most common risk factors. The nutritional team instituted a food protocol: a low calories diet and eliminating biogenic amines-rich foods. During the follow-up (16 months), there was a noticeable weight loss and no arrhythmic episodes happened again. This clinical case provides evidence for a possible new relationship between some kinds of food and heart conduction (defining the very novel field of arrhythmogenic foods and of “nutri-arrhythmias”), recognizing biogenic amines-rich foods abuse as the potential trigger and substrate for atrial fibrillation. Therefore, we suggested that clinical history in patients with new onset AF should also include questions concerning the ingestion of histamine-rich foodstuffs (or other amines-rich food) and alcohol consumption: their effects may result to be synergistic in the alteration of cardiac rhythm and may explain the recurrence of an unexplained atrial fibrillation.

show abstract

Section: Role Of Histaminementioning

confidence: 99%

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Gammone

Vicentini

Riccioni

et al. 2018

Reports

View full text Add to dashboard Cite

show abstract

“…Compounds such as cytokines, neuropeptides, anaphylatoxins, growth factors, and free radicals all have the ability to induce nonimmunological activation of mast cells and basophils. 9,36,37 Other histamineproducing cells with immune function include monocytes, lymphocytes, fibroblasts, ovarian cells, and murine bone marrow-derived macrophages. These cells differ in that they contain far less histamine per cell and unlike mast cells and basophils, do not store histamine in specific granules but secrete it after stimulation triggers synthesis and immediate release.…”

Section: Histamine Measurementmentioning

confidence: 99%

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

Peters

Kovacic

2009

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Histamine plays a key role in the morbidity and mortality associated with allergy, asthma, gastric ulcers, anaphylaxis, sepsis, hemorrhagic shock, anesthesia, surgery, cardiovascular disease, cancer, CNS disorders, and immune-mediated disease. Histamine antagonism has been in common use to block its adverse effects. With recent advances in the understanding of histamine receptor physiology, pharmaceutical agents targeting these receptors have increased the therapeutic options.

show abstract

“…This cytokine has been found to play an important role in the biological function of the immune system, bone marrow, and central nervous system . IL‐6 is an important participant in cardiovascular diseases and atherosclerosis and has been deemed as a diagnostic marker of diseases such as percutaneous transluminal coronary angioplasty, in which the circulating level of IL‐6 is increased .…”

Section: Introductionmentioning

confidence: 99%

Enhancing recombinant interleukin‐6 production yield by fermentation optimization, two‐step denaturing, and one‐step purification

Ahmed

Abbas

Khan

et al. 2017

Biotech and App Biochem

View full text Add to dashboard Cite

Interleukin-6 a pleiotropic cytokine involved in a wide range of biological activities. So the large-scale production of biologically active recombinant human interleukin-6 is important for its structural and functional studies. Here, we report an optimized method for shake flask fermentation and a simplified high-yield purification procedure for the recombinant interleukin-6. This high-yield expression method not only involves the optimization of the fermentation condition but also the single step purification method as well as a two-step denaturing and one-step refolding process. This approach replaces the more conventional procedure of protein solubilization and refolding. Through applying these strategies, the final cell density and overall product yield of the recombinant human interleukin-6 were obtained as 20.4 g as cell biomass and 150 mg as purified active protein from the I-L of the culture. The purified protein was characterized by HPLC and SDS-PAGE. The results of the current work demonstrate that the described method may be used to develop the process for industrial-scale production of the biologically active recombinant interleukin-6 protein.

show abstract

Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty

Abstract: Reactivation of Cpn and HCMV and inflammatory change characterized by increased levels of histamine, CRP and IL-6 following PTCA are suggested. An association might exist between Cpn IgA antibody and histamine levels in patients of unstable angina.

Cited by 11 publications

References 27 publications

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

Enhancing recombinant interleukin‐6 production yield by fermentation optimization, two‐step denaturing, and one‐step purification

Contact Info

Product

Resources

About