Chronic Idiopathic Cough

Haque, Rubaiyat; Usmani, Omar; Barnes, Peter J.

doi:10.1378/chest.127.5.1710

Cited by 210 publications

(55 citation statements)

References 12 publications

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“…Therefore, the effective therapies for CC are one of the most important unmet needs in respiratory diseases. The effectiveness of CC management, however, is highly unsatisfactory [3,11,12]. In the study by Haque et al [3] 42% of patients with CC did not improve despite causal treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of CC management, however, is highly unsatisfactory [3,11,12]. In the study by Haque et al [3] 42% of patients with CC did not improve despite causal treatment. Our previous study showed that only 55% of patients with CC reported significant decrease in cough severity as a result of applied therapy [11].…”

Section: Discussionmentioning

confidence: 99%

“…The results of management of CC in adults are highly unsatisfactory [1,3,4]. It may be a result of either ineffective management of properly diagnosed underlying diseases (difficult-to-treat CC) or failure to diagnose the cause of CC.…”

Section: Introductionmentioning

confidence: 99%

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Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Krakowiak

Dąbrowska

Buła

et al. 2017

Advances in Respiratory Medicine

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Cough is the most common symptom of respiratory diseases. The results of management of chronic cough in adults are still unsatisfactory. Unexplained and difficult-to-treat chronic cough causes significant impairment in patients' quality of life. The results of recent studies suggest that speech therapy (speech language intervention) is one of the few methods which are usefull in management of persistent chronic cough. We present a case of a patient with chronic cough due to chronic nonallergic rhinitis and gastroesophageal reflux disease, who had been unsuccessfully treated for 18 years. In the patient speech therapy resulted in a significant decrease of cough severity and improvement of quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Krakowiak

Dąbrowska

Buła

et al. 2017

Advances in Respiratory Medicine

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“…Esses receptores são ativados por estímulos químicos (ácido, calor e compostos semelhantes à capsaicina) e mecânicos 8 , como observado na Quadro 1. A estimulação química se dá pela ativação de receptores presentes nas fibras C 15,16,17 . Os receptores sensíveis à estímulos mecânicos (mecanorreceptores) estão presentes no estômago, pericárdio, pleura, diafragma, faringe, seios paranasais, tímpanos e meato acústico externo.…”

Section: Fisiopatologiaunclassified

Aspectos fisiopatológicos do reflexo da tosse: uma revisão de literatura

Rodrigues

Galvão

2017

Rev. Med. (São Paulo)

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RESUMO:A tosse é um reflexo de defesa da via aérea em condições fisiológicas. Entretanto, ela compõe o quadro clínico de diversas doenças pulmonares, cardíacas e gastrintestinais. A persistência desse sintoma afeta a qualidade de vida do paciente e acomete 3 a 40% da população geral. Embora possua uma prevalência alta, a fisiopatologia desse sintoma ainda não é bem esclarecida. Nesse sentido, anualmente, são publicados novos achados sobre a fisiopatologia desse sintoma. Assim, o objetivo desse trabalho é realizar uma revisão de literatura sobre a fisiopatologia da tosse. Essa revisão utilizou quarenta publicações presentes nas seguintes bases de dados: Scholar Google, SciELO, Pubmed Central® (PMC), National Center for Biotechnology Information (NCBI) e Medline. A fisiopatologia da tosse está intimamente ligada à estimulação química das fibras-C e à ativação por estímulos mecânicos dos receptores de adaptação rápida (RARs) e dos receptores de estiramento de adaptação lenta (SARs). O conhecimento desses mecanismos fisiopatológicos é importante para o manejo clínico de pacientes com esse sintoma e contribui para o entendimento do mecanismo de ação de antitussígenos que agem sobre esses receptores.Descritores: Tosse/fisiopatologia; Tosse/diagnóstico; Reflexo; Antitussígenos. ABSTRACT:Cough is a reflex of airway defense under physiological conditions. However, it composes the clinical condition of several pulmonary, cardiac and gastrointestinal deseases. The persistence of the symptom affects the welfare of the patient and affects 3 to 40% of the general population. Although it has an important prevalence, the pathophysiology of the symptom is still not clear. In this sense, new symptom findings are published annually. Thus, the objective of the study is to perform a review of the pathophysiology of cough. This review used forty recent publications in the following databases: Scholar Google, SciELO, Pubmed Central® (PMC), National Center for Biotechnology Information (NCBI) and Medline. The pathophysiology of cough is closely linked to the chemical stimulation of C-fibers and to activation by mechanical stimuli of the rapid adaptation receptors (RARs) and the slow adaptating stretch receptors (SARs). The knowledge of these pathophysiological mechanisms is important for the clinical management of patients with this symptom and contributes to the understanding of the mechanism of action of antitussives that act on these receptors.

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“…Chronic cough is often associated with inflammatory airway diseases including chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, lung cancer, or conditions outside the lung such as gastrooesophageal reflux and rhinosinusitis (Fuller and Choudry 1987;Irwin et al 1998; Morice et al 2007a) and is also a side effect of drug treatments such as ACE inhibitors (Sesoko and Kaneko 1985;Lalloo et al 1996;Fahim et al 2011;Faruqi et al 2014). Chronic cough can also be idiopathic in origin, and this can account for 18-42 % of patients at specialist cough clinics (Polley et al 2008;Haque et al 2005), and chronic cough severe enough to interfere with the normal activities of daily life is thought to affect approximately 7 % of the population (Ford et al 2006). Chronic cough patients report cough on exposure to a broad range of normally innocuous stimuli including environmental, mechanical, and temperature changes Khalid et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Targeting TRP channels for chronic cough: from bench to bedside

Bonvini

Birrell

Smith

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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Cough is currently the most common reason for patients to visit a primary care physician in the UK, yet it remains an unmet medical need. Current therapies have limited efficacy or have potentially dangerous side effects. Under normal circumstances, cough is a protective reflex to clear the lungs of harmful particles; however, in disease, cough can become excessive, dramatically impacting patients' lives. In many cases, this condition is linked to inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD), but can also be refractory to treatment and idiopathic in nature. Therefore, there is an urgent need to develop therapies, and targeting the sensory afferent arm of the reflex which initiates the cough reflex may uncover novel therapeutic targets. The cough reflex is initiated following activation of ion channels present on vagal sensory afferents. These ion channels include the transient receptor potential (TRP) family of cation-selective ion channels which act as cellular sensors and respond to changes in the external environment. Many direct activators of TRP channels, including arachidonic acid derivatives, a lowered airway pH, changes in temperature, and altered airway osmolarity are present in the diseased airway where responses to challenge agents which activate airway sensory nerve activity are known to be enhanced. Furthermore, the expression of some TRP channels is increased in airway disease. Together, this makes them promising targets for the treatment of chronic cough. This review will cover the current understanding of the role of the TRP family of ion channels in the activation of airway sensory nerves and cough, focusing on four members, transient receptor potential vanilloid (TRPV) 1, transient receptor potential ankyrin (TRPA) 1, TRPV4, and transient receptor potential melastatin (TRPM) 8 as these represent the channels where most information has been gathered with relevance to the airways. We will describe recent data and highlight the possible therapeutic utility of specific TRP channel antagonists as antitussives in the clinic.

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Chronic Idiopathic Cough

Cited by 210 publications

References 12 publications

Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Speech Therapy—A Non-Pharmacological Method to Manage Difficult-to-treat Chronic Cough

Aspectos fisiopatológicos do reflexo da tosse: uma revisão de literatura

Targeting TRP channels for chronic cough: from bench to bedside

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