Chronic Gastritis and Ulcer Risk

Sipponen, P

doi:10.1080/00365521.1990.12067090

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Gastric cancer and peptic ulcer diseases (excluding NSAID ulcers) are the most serious diseases linked with the chronic H. pylori gastritis [ 60 , 61 , 62 , 63 , 64 , 65 ]. A successful eradication of the H. pylori prevents ulcer recurrences but may also prevent cancers [ 66 , 67 ].…”

Section: Cancer and Peptic Ulcermentioning

confidence: 99%

“…The cancer risk is remarkably low in people without the H. pylori gastritis, i.e., in subjects with a healthy stomach mucosa. The risk rises approximately to two-fold in patients with a pure H. pylori infection, i.e., in subjects with a non-atrophic H. pylori gastritis [ 60 , 61 , 69 ]. Thus, in DU patients, who typically have the non-atrophic H. pylori gastritis, the cancer risk is slightly higher than the cancer risk in healthy subjects, but this risk is still, however, remarkably low as compared to the cancer risk in patients with a severe and advanced atrophic gastritis (see Figure 7 ).…”

Section: Cancer Riskmentioning

confidence: 99%

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Chronic gastritis

Sipponen

Maaroos

2015

Scandinavian Journal of Gastroenterology

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241

167

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Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understanding of the bizarre epidemiology and course of the disease. A life-long and aggressive inflammation in gastritis results in destruction (atrophic gastritis) of stomach mucosa with time (years and decades). The progressive worsening of atrophic gastritis results subsequently in dysfunctions of stomach mucosa. Atrophic gastritis will finally end up in a permanently acid-free stomach in the most extreme cases. Severe atrophic gastritis and acid-free stomach are the highest independent risk conditions for gastric cancer known so far. In addition to the risks of malignancy and peptic ulcer, acid-free stomach and severe forms of atrophic gastritis may associate with failures in absorption of essential vitamins, like vitamin B12, micronutrients (like iron, calcium, magnesium and zinc), diet and medicines.

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Section: Cancer and Peptic Ulcermentioning

confidence: 99%

Section: Cancer Riskmentioning

confidence: 99%

Chronic gastritis

Sipponen

Maaroos

2015

Scandinavian Journal of Gastroenterology

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241

167

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“…oxyntic gland atrophy [4,41]. In contrast to proximal GU, patients with distal antral GU or GU associated with DU have normal or even increased levels of acid secretion.…”

Section: Helicobacter Pylori Duodenitis Acid Secretion and Gastricmentioning

confidence: 99%

Peptic Ulcer Disease

Soll

Graham

2008

Textbook of Gastroenterology

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“…The rational for rhis is that atrophy will reflect the imrn or corpus which, in turn, can hc related to the risk of developing peptic ulcer disease. 26 Chronic gastritis with no loss of glands, regardless of depth of inflammation, is termed 'superficial gastritis'. Atrophy is graded as mild, moderate or severe.…”

Section: Historical Background and Previous Classificationsmentioning

confidence: 99%

“…'~ Atrophy of the gastric glands influences gastric function and the risk of developing peptic ulcer disease. 26 Whether it is an inevitable sequel to inflammation and part of a progressive cycle in particular patient groups either initiated by a single or a variety of inflammatory insults, is at the root of differences between several of the classifications outlined. 16"8-z1 A possible resolution to the controversy over the significance of atrophy and metaplasia may be found in the longitudinal studies of Kekki et ~1 .…”

Section: Correlation With Other Clas Sificatlonsmentioning

confidence: 99%